Cited by 1,106HIV Research and TreatmentHIV-related health complications and treatmentsHIV/AIDS Research and Interventions

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. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

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Sandler, Netanya G., Wand, Handan, Roque, Annelys, Law, Matthew, Nason, Martha C., Nixon, Daniel E., Pedersen, Court, Ruxrungtham, Kiat, Lewin, Sharon R., Emery, Sean, Neaton, James D., Brenchley, Jason M., Deeks, Steven G., Sereti, Irini, Douek, Daniel C.·2011·The Journal of Infectious Diseases

DOI 10.1093/infdis/jiq118PMC PMC3071127

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Abstract

BACKGROUND: Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to systemic immune activation, which is an independent predictor of HIV disease progression. The association of microbial translocation with clinical outcome remains unknown. METHODS: This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples. RESULTS: Subjects with the highest quartile of sCD14 levels had a 6-fold higher risk of death than did those in the lowest quartile (95% confidence interval, 2.2-16.1; P<.001), with minimal change after adjustment for inflammatory markers, CD4(+) T cell count, and HIV RNA level. No other marker was significantly associated with clinical outcomes. I-FABP, LPS, and sCD14 were increased and EndoCAb was decreased in study subjects, compared with healthy volunteers. sCD14 level correlated with levels of IL-6, C-reactive protein, serum amyloid A and D-dimer. CONCLUSIONS: sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection. Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection.

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Authors: Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., Neaton, J. D., Brenchley, J. M., Deeks, S. G., Sereti, I., & Douek, D. C.
Affiliations: UNSW Sydney (AU)
National Institutes of Health (US)
Virginia Commonwealth University (US)
University of Southern Denmark (DK)
Chulalongkorn University (TH)
Burnet Institute (AU)
University of Minnesota (US)
San Francisco General Hospital (US)
ORCID: Wand, Handan
Law, Matthew
Nason, Martha C.
Ruxrungtham, Kiat
Lewin, Sharon R.
Emery, Sean
Neaton, James D.
Brenchley, Jason M.
Deeks, Steven G.
Sereti, Irini
Douek, Daniel C.
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2011-03-15
Volume: 203
Issue: 6
Pages: 780-790
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiq118
PMC: PMC3071127
OpenAlex: W2098152094
Cited by: 1,106
References: 50
Citations by year: 2026: 32 · 2025: 31 · 2024: 59 · 2023: 48 · 2022: 67 · 2021: 70 · 2020: 76 · 2019: 70 · 2018: 69 · 2017: 83 · 2016: 107 · 2015: 97 · 2014: 111 · 2013: 93 · 2012: 65
FWCI: 37.22
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: National Center for Genetic Engineering and Biotechnology
National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI 76174, P01AI076174)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: soluble CD14, HIV infection, mortality prediction, microbial translocation, intestinal permeability, lipopolysaccharide, endotoxin core antibody, intestinal fatty acid binding protein, cardiovascular disease, AIDS, innate immune activation, SMART trial, prognostic factors
MeSH terms: Adult, Cause of Death, Humans, Lipopolysaccharides, Male, Middle Aged, RNA, Viral, Biomarkers, CD4-Positive T-Lymphocytes, HIV Infections, Logistic Models, Case-Control Studies, Lipopolysaccharide Receptors, Fatty Acid-Binding Proteins, Young Adult

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. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

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