The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection
Open accessAbstract
BACKGROUND: Understanding the earliest central nervous system (CNS) events during human immunodeficiency virus (HIV) infection is crucial to knowledge of neuropathogenesis, but these have not previously been described in humans. METHODS: Twenty individuals who had acute HIV infection (Fiebig stages I-IV), with average 15 days after exposure, underwent clinical neurological, cerebrospinal fluid (CSF), magnetic resonance imaging, and magnetic resonance spectroscopy (MRS) characterization. RESULTS: HIV RNA was detected in the CSF from 15 of 18 subjects as early as 8 days after estimated HIV transmission. Undetectable CSF levels of HIV (in 3 of 18) was noted during Fiebig stages I, II, and III, with plasma HIV RNA levels of 285651, 2321, and 81978 copies/mL, respectively. On average, the CSF HIV RNA level was 2.42 log(10) copies/mL lower than that in plasma. There were no cases in which the CSF HIV RNA level exceeded that in plasma. Headache was common during the acute retroviral syndrome (in 11 of 20 subjects), but no other neurological signs or symptoms were seen. Intrathecal immune activation was identified in some subjects with elevated CSF neopterin, monocyte chemotactic protein/CCL2, and interferon γ-induced protein 10/CXCL-10 levels. Brain inflammation was suggested by MRS. CONCLUSIONS: CSF HIV RNA was detectable in humans as early as 8 days after exposure. CNS inflammation was apparent by CSF analysis and MRS in some individuals during acute HIV infection.
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Cited by
Gisslén, M., Price, R. W., Andreasson, U., Norgren, N., Nilsson, S., Hagberg, L., Fuchs, D., Spudich, S., Blennow, K., & Zetterberg, H. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.036 · Cited by 481
Self-citationMagnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain
Chang, L., Munsaka, S. M., Kraft-Terry, S., & Ernst, T. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9460-x · Cited by 305
Biomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients
Jessen Krut, J., Mellberg, T., Price, R. W., Hagberg, L., Fuchs, D., Rosengren, L., Nilsson, S., Zetterberg, H., & Gisslén, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088591 · Cited by 167
Neurology of Acute Viral Infections
Krett, J. D., Beckham, J. D., Tyler, K. L., Piquet, A. L., Chauhan, L., Wallace, C. J., Pastula, D. M., & Kapadia, R. K. (2022) · The Neurohospitalist · doi:10.1177/19418744221104778 · Cited by 13
A reappraisal on amyloid cascade hypothesis: The role of chronic infection in Alzheimer’s disease
Phuna, Z. X., & Madhavan, P. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2045290 · Cited by 12
Metadata
- Authors
- Valcour, V., Chalermchai, T., Sailasuta, N., Marovich, M., Lerdlum, S., Suttichom, D., Suwanwela, N. C., Jagodzinski, L., Michael, N., Spudich, S., van Griensven, F., de Souza, M., Kim, J., & Ananworanich, J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-02
- Volume
- 206
- Issue
- 2
- Pages
- 275-282
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2117009199
- Cited by
- 522
- References
- 27
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Valcour, V., Chalermchai, T., Sailasuta, N., Marovich, M., Lerdlum, S., Suttichom, D., Suwanwela, N. C., Jagodzinski, L., Michael, N., Spudich, S., van Griensven, F., de Souza, M., Kim, J., & Ananworanich, J. (2012). Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jis326
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