The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Magnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain
Open accessAbstract
Proton magnetic resonance spectroscopy (1H MRS) has been applied to numerous clinical studies, especially for neurological disorders. This technique can non-invasively evaluate brain metabolites and neurochemicals in selected brain regions and is particularly useful for assessing neuroinflammatory disorders. Neurometabolites assessed with MRS include the neuronal markers N-acetylaspartate (NAA) and glutamate (Glu), as well as the glial marker myo-inositol (MI). Therefore, the concentrations of these metabolites typically correspond to disease severity and often correlate well with clinical variables in the various brain disorders. Neuroinflammation with activated astrocytes and microglia in brain disorders are often associated with elevated MI, and to a lesser extent elevated total creatine (tCr) and choline containing compounds (Cho), which are found in higher concentrations in glia than neurons, while neuronal injury is indicated by lower than normal levels of NAA and Glu. This review summarizes the neurometabolite abnormalities found in MRS studies performed in patients with neuroinflammatory disorders or neuropathic pain, which also may be associated with neuroinflammation. These brain disorders include multiple sclerosis, neuroviral infections (including Human Immunodeficiency virus and Hepatitis C), degenerative brain disorders (including Alzheimer’s disease and Parkinson’s disease), stimulant abuse (including methamphetamine and cocaine) as well as several chronic pain syndromes.
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Cites
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265
Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986
Multinuclear NMR Studies on the Energy Metabolism of Glial and Neuronal Cells
Brand, A., Richter-Landsberg, C., & Leibfritz, D. (1993) · Developmental Neuroscience · doi:10.1159/000111347 · Cited by 884
Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
BRUN, A., & ENGLUND, E. (1981) · Histopathology · doi:10.1111/j.1365-2559.1981.tb01818.x · Cited by 561
Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection
Valcour, V., Chalermchai, T., Sailasuta, N., Marovich, M., Lerdlum, S., Suttichom, D., Suwanwela, N. C., Jagodzinski, L., Michael, N., Spudich, S., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis326 · Cited by 522
Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water
Ernst, T., Kreis, R., & Ross, B. D. (1993) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1993.1055 · Cited by 504
Self-citationEvidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
Srinivasan, R., Sailasuta, N., Hurd, R., Nelson, S., & Pelletier, D. (2005) · Brain · doi:10.1093/brain/awh467 · Cited by 465
Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease
Forton, D. M., Thomas, H. C., Murphy, C. A., Allsop, J. M., Foster, G. R., Main, J., Wesnes, K. A., & Taylor-Robinson, S. D. (2002) · Hepatology · doi:10.1053/jhep.2002.30688 · Cited by 450
Cited by
Haroon, E., Fleischer, C. C., Felger, J. C., Chen, X., Woolwine, B. J., Patel, T., Hu, X. P., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.206 · Cited by 250
Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD
Miller, M. W., Lin, A. P., Wolf, E. J., & Miller, D. R. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000167 · Cited by 237
Chronic inflammation in multiple sclerosis - seeing what was always there
Matthews, P. M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0240-y · Cited by 128
Microglia ablation alleviates myelin-associated catatonic signs in mice
Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R. A., Pan, H., Goebbels, S., Begemann, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci97032 · Cited by 107
Bossong, M. G., Antoniades, M., Azis, M., Samson, C., Quinn, B., Bonoldi, I., Modinos, G., Perez, J., Howes, O. D., Stone, J. M., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3252 · Cited by 81
Metadata
- Authors
- Chang, L., Munsaka, S. M., Kraft-Terry, S., & Ernst, T.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2013-05-12
- Volume
- 8
- Issue
- 3
- Pages
- 576-593
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2086504454
- Cited by
- 305
- References
- 109
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- green
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