Human papillomavirus 16-specific T-cell responses and spontaneous regression of anal high-grade squamous intraepithelial lesions.

Tong, Winnie W. Y.; Shepherd, Kelsee; Garland, Suzanne; Meagher, Alan; Templeton, David J.; Fairley, Christopher K.; Jin, Fengyi; Poynten, I. Mary; Zaunders, John; Hillman, Richard J.; Grulich, Andrew E.; Kelleher, Anthony D.; Carr, Andrew

doi:10.1093/infdis/jiu461

Cited by 36Cervical Cancer and HPV ResearchColorectal and Anal CarcinomasHIV Research and Treatment

Human papillomavirus 16-specific T-cell responses and spontaneous regression of anal high-grade squamous intraepithelial lesions.

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Tong, Winnie W. Y., Shepherd, Kelsee, Garland, Suzanne, Meagher, Alan, Templeton, David J., Fairley, Christopher K., Jin, Fengyi, Poynten, I. Mary +5 more·2015·Journal of Infectious Diseases

DOI 10.1093/infdis/jiu461

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Abstract

BACKGROUND: Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression. METHODS: In men who have sex with men undergoing anal cytology and high-resolution anoscopy, we measured responses to HPV-16 oncogenic proteins E6 and E7, using the CD25/CD134 assay for CD4(+) antigen-specific T cells and intracellular cytokine staining for CD4(+) and CD8(+) antigen-specific T cells. RESULTS: Of 134 participants (mean [SD] age, 51 [9.3] years; 31 [23.1%] infected with human immunodeficiency virus), 51 (38.1%) had HSIL. E6- and E7-specific CD4(+) T-cell responses were detected in 80 (59.7%) and 40 (29.9%) of the participants, respectively, and E6- and E7-specific CD8(+) T-cell responses were each detected in 25 (18.7%). HSIL was significantly associated with E7-specific CD8(+) T-cell responses (odds ratio, 4.09 [95% confidence interval, 1.55-10.77], P = .004), but not with any CD4(+) T-cell response (P ≥ .09). Twenty-six participants had HSIL a mean of 1 year before measurement of T-cell responses, and 6 (23%) of them were regressors. Five regressors (83%) had E6-specific CD4(+) T-cell responses vs 7 of 20 (35%) nonregressors (Pexact = .065). CONCLUSIONS: Systemic HPV-16 E6- and E7-specific T-cell responses were common in men who have sex with men. E6-specific CD4(+) T-cell responses may be associated with recent HSIL regression. CLINICAL TRIALS REGISTRATION: NCT02007421.

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Evidence exists that HSIL might spontaneously regress without treatment.
“In addition, evidence exists that HSIL might spontaneously regress without treatment (1294,1295).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1294]

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Authors: Tong, W. W. Y., Shepherd, K., Garland, S., Meagher, A., Templeton, D. J., Fairley, C. K., Jin, F., Poynten, I. M., Zaunders, J., Hillman, R. J., Grulich, A. E., Kelleher, A. D., & Carr, A.
Affiliations: St Vincent's Hospital Sydney (AU)
Royal Women's Hospital (AU)
Royal Prince Alfred Hospital (AU)
The University of Melbourne (AU)
UNSW Sydney (AU)
The University of Sydney (AU)
ORCID: Tong, Winnie W. Y.
Shepherd, Kelsee
Garland, Suzanne
Meagher, Alan
Templeton, David J.
Fairley, Christopher K.
Jin, Fengyi
Poynten, I. Mary
Zaunders, John
Hillman, Richard J.
Grulich, Andrew E.
Kelleher, Anthony D.
Carr, Andrew
Venue: Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2014-08-19
Volume: 211
Issue: 3
Pages: 405-415
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiu461
OpenAlex: W2153992214
Cited by: 36
References: 51
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2
FWCI: 2.52
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Surgery › Colorectal and Anal Carcinomas
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: HPV16, high-grade squamous intraepithelial lesion, anal intraepithelial neoplasia, spontaneous regression, E7 antigen, CD4+ T cells, CD8+ T cells, men who have sex with men, HIV infection
MeSH terms: Anal Canal, Anus Neoplasms, Uterine Cervical Neoplasms, Female, Humans, Male, Middle Aged, Oncogene Proteins, Viral, Repressor Proteins, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Homosexuality, Male, Papillomavirus Infections, Papillomavirus E7 Proteins, Human papillomavirus 16, Squamous Intraepithelial Lesions of the Cervix

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Human papillomavirus 16-specific T-cell responses and spontaneous regression of anal high-grade squamous intraepithelial lesions.

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