Cited by 249Escherichia coli research studiesUrinary Tract Infections ManagementBacterial Infections and Vaccines

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Extraintestinal Pathogenic Escherichia coli , a Common Human Pathogen: Challenges for Vaccine Development and Progress in the Field

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Poolman, Jan T., Wacker, Michael·2016·Journal of Infectious Diseases

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common gram-negative bacterial pathogen in humans. ExPEC causes the vast majority of urinary tract infections (UTIs), is a leading cause of adult bacteremia, and is the second most common cause of neonatal meningitis. Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment and is implicated in increasing numbers of hospitalizations and deaths and increasing healthcare costs associated with ExPEC infections. An effective vaccine against ExPEC infection is urgently needed. The O antigen, a component of the surface lipopolysaccharide, has been identified as a promising vaccine target. With the availability of a novel bioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced at industrial scale. Clinical proof of concept of a 4-valent O antigen conjugate vaccine is ongoing. An ExPEC vaccine effective against strains that are associated with major diseases and resistant to multiple drugs could be routinely delivered to individuals at risk of developing severe E. coli infection, such as elderly people, individuals undergoing abdominal surgery and prostatic biopsy procedures, and persons at risk of recurrent and/or complicated UTI.

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Registry

Crossref · 10.1093/infdis/jiv429

Cites

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Figures

Figure 1. Distribution of pathogens among isolates from 80 089 hospital admissions in 19 US hospitals between 2007 and 2010 [10]. Abbreviations: A. baumannii, Acinetobacter baumannii; E. coli, Escherichia coli; E. faecalis, Enterococcus faecalis; E. faecium, Enterococcus faecium; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; S. aureus, Staphylococcus aureus.
Figure 1. Distribution of pathogens among isolates from 80 089 hospital admissions in 19 US hospitals between 2007 and 2010 [10]. Abbreviations: A. baumannii, Acinetobacter baumannii; E. coli, Escherichia coli; E. faecalis, Enterococcus faecalis; E. faecium, Enterococcus faecium; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; S. aureus, Staphylococcus aureus.CC BY-NC-ND · PubMed Central
Figure 2. A, Incidence of Escherichia coli bacteremia, by age, in Auckland, New Zealand, between 2005 and 2011. The figure is reproduced from the article by Williamson et al [20]. B, rising numbers of E. coli bacteremia isolates reported to the European Antimicrobial Resistance Surveillance System between 2002 and 2008. Data are from the article by De Kraker et al [16]. Abbreviations: E. coli, Escherichia coli; S. aureus, Staphylococcus aureus; S. pneumoniae, Streptococcus pneumoniae.
Figure 2. A, Incidence of Escherichia coli bacteremia, by age, in Auckland, New Zealand, between 2005 and 2011. The figure is reproduced from the article by Williamson et al [20]. B, rising numbers of E. coli bacteremia isolates reported to the European Antimicrobial Resistance Surveillance System between 2002 and 2008. Data are from the article by De Kraker et al [16]. Abbreviations: E. coli, Escherichia coli; S. aureus, Staphylococcus aureus; S. pneumoniae, Streptococcus pneumoniae.CC BY-NC-ND · PubMed Central
Figure 3. Escherichia coli O serotypes causing extraintestinal infections. Data are from the article by Orskov et al [41]. Abbreviation: UTIs, urinary tract infections.
Figure 3. Escherichia coli O serotypes causing extraintestinal infections. Data are from the article by Orskov et al [41]. Abbreviation: UTIs, urinary tract infections.CC BY-NC-ND · PubMed Central
Figure 4. Process of in vivo bioconjugation, using recombinant Escherichia coli. Campylobacter oligosaccharyltransferase (PglB) transfers selected O polysaccharides (devoid of lipids) to the Pseudomonas aeruginosa exoprotein A (EPA) protein carrier present in the periplasm. Abbreviation: SEC, secretory pathway.
Figure 4. Process of in vivo bioconjugation, using recombinant Escherichia coli. Campylobacter oligosaccharyltransferase (PglB) transfers selected O polysaccharides (devoid of lipids) to the Pseudomonas aeruginosa exoprotein A (EPA) protein carrier present in the periplasm. Abbreviation: SEC, secretory pathway.CC BY-NC-ND · PubMed Central
Figure 5. Challenges to extraintestinal pathogenic Escherichia coli vaccine development. Individual challenges to vaccine development need to be surmounted to achieve successful technical development, appropriate strain selection, and demonstration of efficacy in the target population. Abbreviation: UTI, urinary tract infection.
Figure 5. Challenges to extraintestinal pathogenic Escherichia coli vaccine development. Individual challenges to vaccine development need to be surmounted to achieve successful technical development, appropriate strain selection, and demonstration of efficacy in the target population. Abbreviation: UTI, urinary tract infection.CC BY-NC-ND · PubMed Central

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Citations

Cites

Show all 48 references

Research works printed but not linked: 4

  1. Vahlne, 1945, Serological typing of the colon bacteria, with special reference to the occurrence of B. coli in man under normal and pathological conditions, particularly in appendicitis, Acta Path Microbiol Scand, 62, 1
  2. Sjostedt, 1946, Pathogenicity of certain serological types of B. coli: their mouse toxicity, hemolytic power, capacity for skin necrosis and resistance to phagocytosis and bactericidal faculties of human blood, Acta Path Microbiol Scand, 63, 1
  3. Elixhauser A , Friedman B , Stranges E . Septicemia in U.S. Hospitals, 2009. Statistical brief 122. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville, MD: Agency for Health Care Policy and Research, 2006. http://www.ncbi.nlm.nih.gov/books/NBK65391/ . Accessed 27 January 2015.
  4. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. The Review on Antimicrobial Resistance Chaired by Jim O'Neill, 2014. http://www.his.org.uk/files/4514/1829/6668/AMR_Review_Paper_-_Tackling_a_crisis_for_the_health_and_wealth_of_nations_1.pdf . Accessed 26 December 2014.

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Metadata

Authors
Poolman, J. T., & Wacker, M.
Affiliations
Janssen (Netherlands) (NL)
Corresponding author
Poolman, Jan T.
Venue
Journal of Infectious Diseases
Published
2015-09-02
Volume
213
Issue
1
Pages
6-13
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2243816940
Cited by
246
References
48
Citations by year
2026: 20 · 2025: 25 · 2024: 31 · 2023: 29 · 2022: 30 · 2021: 21 · 2020: 27 · 2019: 26 · 2018: 15 · 2017: 11 · 2016: 11
FWCI
1.36
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • The Journal of Infectious Diseases (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
  • Health Sciences › Medicine › Urology › Urinary Tract Infections Management
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords
extraintestinal pathogenic Escherichia coli, vaccine development, lipopolysaccharide, urinary tract infection, bacteremia, neonatal meningitis, multidrug resistance, bioconjugation, multivalent vaccine, vaccine targets
MeSH terms
Escherichia coli, Escherichia coli Infections, Humans, Urinary Tract Infections, O Antigens, Escherichia coli Vaccines, Drug Resistance, Bacterial

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