Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem
Open accessAbstract
Escherichia coli is probably the best-known bacterial species and one of the most frequently isolated organisms from clinical specimens. Despite this, underappreciation and misunderstandings exist among medical professionals and the lay public alike regarding E. coli as an extraintestinal pathogen. Underappreciated features include (i) the wide variety of extraintestinal infections E. coli can cause, (ii) the high incidence and associated morbidity, mortality, and costs of these diverse clinical syndromes, (iii) the pathogenic potential of different groups of E. coli strains for causing intestinal versus extraintestinal disease, and (iv) increasing antimicrobial resistance. In this era in which health news often sensationalizes uncommon infection syndromes or pathogens, the strains of E. coli that cause extraintestinal infection are an increasingly important endemic problem and underappreciated "killers". Billions of health care dollars, millions of work days, and hundreds of thousands of lives are lost each year to extraintestinal infections due to E. coli. New treatments and prevention measures will be needed for improved outcomes and a diminished disease burden.
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MDR Escherichia coli infection is usually associated with urinary tract related infections and bacteremia.
“MDR Escherichia coli infection is usually associated with urinary tract related infections and bacteremia [6–9].”
From Multidrug-Resistant<i> Escherichia coli</i> Resulting in Postpartum Necrotizing Endomyometritis (2019) · cites this paper as [9]
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Multidrug-Resistant<i> Escherichia coli</i> Resulting in Postpartum Necrotizing Endomyometritis
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- Authors
- Russo, T. A., & Johnson, J. R.
- Affiliations
- Buffalo VA Medical Center (US)
- University of Minnesota (US)
- Corresponding author
- Russo, Thomas A.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 5
- Issue
- 5
- Pages
- 449-456
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2094448747
- Cited by
- 801
- References
- 1
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 55 · 2023: 39 · 2022: 40 · 2021: 58 · 2020: 47 · 2019: 42 · 2018: 51 · 2017: 29 · 2016: 46 · 2015: 44 · 2014: 33 · 2013: 40 · 2012: 36
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk047504-08)
- National Heart, Lung, and Blood Institute (HL-69763, R01HL069763)
- National Institute of Allergy and Infectious Diseases (AI 42059, R01AI042059)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 47504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- extraintestinal infections, Escherichia coli, antimicrobial resistance, economic burden, morbidity and mortality, endemic infection, infection control, health care costs
- MeSH terms
- Escherichia coli, Escherichia coli Infections, Humans, Respiratory Tract Infections, Surgical Wound Infection, Urinary Tract Infections, Incidence, Bacteremia, Endemic Diseases
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