Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

Henter, J., Horne, A., Aricò, M., Egeler, R. M., Filipovich, A. H., Imashuku, S., Ladisch, S., McClain, K. L., Webb, D. K. H., Winiarski, J. H., et al. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.21039 · Cited by 5,396 · see citing works

Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome

Fardet, L., Galicier, L., Lambotte, O., Marzac, C., Aumont, C., Chahwan, D., Coppo, P., & Hejblum, G. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38690 · Cited by 1,508 · see citing works

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

Ravelli, A., Minoia, F., Davì, S., Horne, A., Bovis, F., Pistorio, A., Aricò, M., Avčin, T., Behrens, E. M., Benedetti, F. D., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39332 · Cited by 770 · see citing works

Identification of the homologous beige and Chediak–Higashi syndrome genes

Barbosa, M. D. F. S., Nguyen, Q. A., Tchernev, V. T., Ashley, J., Detter, J. C., Blaydes, S. M., Brandt, S. J., Chotai, D., Hodgman, C. T., Solari, R. C. E., et al. (1996) · Nature · doi:10.1038/382262a0 · Cited by 549 · see citing works

Lung Pathology in Fatal Novel Human Influenza A (H1N1) Infection

Mauad, T., Hajjar, L. A., Callegari, G. D., da Silva, L. F. F., Schout, D., Galas, F. R. B. G., Alves, V. A. F., Malheiros, D. M. A. C., Auler, J. O. C., Ferreira, A. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1420oc · Cited by 547 · see citing works

Clinical Features, Treatment, and Outcome of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A Multinational, Multicenter Study of 362 Patients

Minoia, F., Davì, S., Horne, A., Demirkaya, E., Bovis, F., Li, C., Lehmberg, K., Weitzman, S. S., Insalaco, A., Wouters, C. H., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38802 · Cited by 430 · see citing works

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH

Zhang, K., Jordan, M. B., Marsh, R. A., Johnson, J. A., Kissell, D., Meller, J., Villanueva, J., Risma, K. A., Wei, Q., Klein, P. S., et al. (2011) · Blood · doi:10.1182/blood-2011-07-370148 · Cited by 428 · see citing works

The structural basis for membrane binding and pore formation by lymphocyte perforin

Law, R. H. P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T. T., Baran, K., Dunstone, M. A., D’Angelo, M. E., Orlova, E. V., Coulibaly, F., Verschoor, S., et al. (2010) · Nature · doi:10.1038/nature09518 · Cited by 418 · see citing works

Delayed Clearance of Viral Load and Marked Cytokine Activation in Severe Cases of Pandemic H1N1 2009 Influenza Virus Infection

To, K. K., Hung, I. F., Li, I. W. S., Lee, K., Koo, C., Yan, W., Liu, R. W., Ho, K., Chu, K., Watt, C., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/650581 · Cited by 417 · see citing works

Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

Ravelli, A., Magni‐Manzoni, S., Pistorio, A., Besana, C., Foti, T., Ruperto, N., Viola, S., & Martini, A. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.12.016 · Cited by 409 · see citing works

Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine- Directed Therapies

Schulert, G. S., & Grom, A. A. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-061813-012806 · Cited by 401 · see citing works

Hemophagocytic lymphohistiocytosis (HLH) and related disorders

Filipovich, A. H. (2009) · Hematology · doi:10.1182/asheducation-2009.1.127 · Cited by 400 · see citing works

Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment

Ravelli, A., Grom, A. A., Behrens, E. M., & Cron, R. Q. (2012) · Genes and Immunity · doi:10.1038/gene.2012.3 · Cited by 381 · see citing works

Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome

Grom, A. A., Villanueva, J. M., Lee, S., Goldmuntz, E. A., Passo, M. H., & Filipovich, A. H. (2003) · The Journal of Pediatrics · doi:10.1067/mpd.2003.110 · Cited by 284 · see citing works

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin‐6: Implications for the Pathogenesis of Macrophage Activation Syndrome

Cifaldi, L., Prencipe, G., Caiello, I., Bracaglia, C., Locatelli, F., Benedetti, F. D., & Strippoli, R. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39295 · Cited by 267 · see citing works

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis

Vastert, S. J., van Wijk, R., D’Urbano, L. E., de Vooght, K. M. K., de Jager, W., Ravelli, A., Magni‐Manzoni, S., Insalaco, A., Cortis, E., van Solinge, W. W., et al. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep418 · Cited by 229 · see citing works

Critically Ill Children During the 2009–2010 Influenza Pandemic in the United States

Randolph, A. G., Vaughn, F., Sullivan, R., Rubinson, L., Thompson, B. T., Yoon, G., Smoot, E., Rice, T. W., Loftis, L. L., Helfaer, M., et al. (2011) · Pediatrics · doi:10.1542/peds.2011-0774 · Cited by 222 · see citing works

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

Cetica, V., Sieni, E., Pende, D., Danesino, C., Fusco, C. D., Locatelli, F., Micalizzi, C., Putti, M. C., Biondi, A., Fagioli, F., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.048 · Cited by 209 · see citing works

Whole‐Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis

Kaufman, K. M., Linghu, B., Szustakowski, J. D., Husami, A., Yang, F., Zhang, K., Filipovich, A. H., Fall, N., Harley, J. B., Nirmala, N. R., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38793 · Cited by 207 · see citing works

Apparent genotype–phenotype correlation in childhood, adolescent, and adult Chediak‐Higashi syndrome

Karim, M. A., Suzuki, K., Fukai, K., Oh, J., Nagle, D. L., Moore, K. J., Barbosa, E., Falik‐Borenstein, T. C., Filipovich, A. H., Ishida, Y., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10184 · Cited by 192 · see citing works

Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13‐4 polymorphisms

Zhang, K., Biroschak, J., Glass, D. N., Thompson, S. D., Finkel, T. H., Passo, M. H., Binstadt, B. A., Filipovich, A. H., & Grom, A. A. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23734 · Cited by 182 · see citing works

Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis

Bode, S. F. N., Lehmberg, K., Maul‐Pavicic, A., Vraetz, T., Janka, G., Stadt, U. Z., & Ehl, S. R. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3843 · Cited by 162 · see citing works

Genetic Defects in Cytolysis in Macrophage Activation Syndrome

Zhang, M., Behrens, E. M., Atkinson, T. P., Shakoory, B., Grom, A. A., & Cron, R. Q. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0439-2 · Cited by 148 · see citing works

Autopsy Findings in Eight Patients With Fatal H1N1 Influenza

Harms, P. W., Schmidt, L. A., Smith, L. B., Newton, D. W., Pletneva, M., Walters, L. L., Tomlins, S. A., Fisher‐Hubbard, A., Napolitano, L. M., Park, P. K., et al. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcp35kozsavnqzw · Cited by 145 · see citing works

Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis

Zhang, K., Chandrakasan, S., Chapman, H. M., Valencia, C. A., Husami, A., Kissell, D., Johnson, J. A., & Filipovich, A. H. (2014) · Blood · doi:10.1182/blood-2014-05-573105 · Cited by 141 · see citing works

Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion

Spessott, W., Sanmillan, M. L., McCormick, M. E., Patel, N., Villanueva, J. M., Zhang, K., Nichols, K. E., & Giraudo, C. G. (2015) · Blood · doi:10.1182/blood-2014-11-610816 · Cited by 125 · see citing works

Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis

Risma, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26217 · Cited by 118 · see citing works

Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Davì, S., Minoia, F., Pistorio, A., Horne, A., Consolaro, A., Rosina, S., Bovis, F., Cimaz, R., Gámir, M. L. G., Ilowite, N. T., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38769 · Cited by 116 · see citing works

Clinical features and functional significance of the P369S/R408Q variant in pyrin, the familial Mediterranean fever protein

Ryan, J., Masters, S. L., Booty, M. G., Habal, N., Alexander, J. D., Barham, B. K., Remmers, E. F., Barron, K. S., Kastner, D. L., & Aksentijevich, I. A. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.113415 · Cited by 101 · see citing works

Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection

Beutel, G., Wiesner, O., Eder, M., Hafer, C., Schneider, A. S., Kielstein, J. T., Kühn, C., Heim, A., Ganzenmueller, T., Kreipe, H.-H., et al. (2011) · Critical Care · doi:10.1186/cc10073 · Cited by 96 · see citing works

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Voskoboinik, I., Sutton, V. R., Ciccone, A., House, C. M., Chia, J., Darcy, P. K., Yagita∥, H., & Trapani, J. A. (2007) · Blood · doi:10.1182/blood-2007-02-072850 · Cited by 94 · see citing works

Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome

Jessen, B., Maul‐Pavicic, A., Ufheil, H., Vraetz, T., Enders, A., Lehmberg, K., Längler, A., Gross‐Wieltsch, U., Bay, A., Kaya, Z., et al. (2011) · Blood · doi:10.1182/blood-2011-05-356113 · Cited by 89 · see citing works

Histoplasmosis-Induced Hemophagocytic Syndrome: A Case Series and Review of the Literature

Townsend, J., Shanbhag, S., Hancock, J. S., Bowman, K. A., & Nijhawan, A. E. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv055 · Cited by 88 · see citing works

Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function

Voskoboinik, I., & Trapani, J. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00441 · Cited by 75 · see citing works

A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype

Stadt, U. Z., Beutel, K., Weber, B., Kabisch, H., Schneppenheim, R., & Janka, G. (2004) · Blood · doi:10.1182/blood-2004-02-0733 · Cited by 60 · see citing works

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

House, I. G., Thia, K. Y. T., Brennan, A. J., Tothill, R. W., Dobrovic, A., Yeh, W. Z., Saffery, R., Chatterton, Z., Trapani, J. A., & Voskoboinik, I. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.1 · Cited by 53 · see citing works

Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

Endo, M., Zoltick, P. W., Peranteau, W. H., Radu, A. P., Muvarak, N. E., Ito, M., Yang, Z., Cotsarelis, G., & Flake, A. W. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300332 · Cited by 52 · see citing works

FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity

Selliah, N., Zhang, M., White, S., Zoltick, P. W., Sawaya, B. E., Finkel, T. H., & Cron, R. Q. (2008) · Virology · doi:10.1016/j.virol.2008.08.033 · Cited by 44 · see citing works

The 2009 Pandemic Influenza Virus: Where Did It Come from, Where Is It Now, and Where Is It Going?

York, I. A., & Donis, R. O. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_221 · Cited by 43 · see citing works

Cytotoxic therapy for severe swine flu A/H1N1

Henter, J., Palmkvist-Kaijser, K., Holzgraefe, B., Bryceson, Y. T., & Palmér, K. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61345-1 · Cited by 41 · see citing works

Features of the new pandemic influenza A/H1N1/2009 virus: virology, epidemiology, clinical and public health aspects

Tang, J. W.-T., Shetty, N., & Lam, T. T. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3283375727 · Cited by 40 · see citing works

Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients

An, Ö., Gürsoy, A., Gürgey, A., & Keskin, Ö. (2013) · Protein Science · doi:10.1002/pro.2265 · Cited by 31 · see citing works

Hemophagocytic Lymphohistiocytosis Induced by Severe Pandemic Influenza A (H1N1) 2009 Virus Infection: A Case Report

Zhang, X., Ye, X., Feng, D.-X., Han, J., Li, D., & Zhang, C. (2011) · Case Reports in Medicine · doi:10.1155/2011/951910 · Cited by 28 · see citing works

Mutations of familial hemophagocytic lymphohistiocytosis (FHL) related genes and abnormalities of cytotoxicity function tests in patients with macrophage activation syndrome (MAS) occurring in systemic juvenile idiopathic arthritis (sJIA)

Bracaglia, C., Sieni, E., Ros, M. D., Fusco, C. D., Micalizzi, C., Cetica, V., Ciambotti, B., Coniglio, M. L., Insalaco, A., Benedetti, F. D., et al. (2014) · Pediatric Rheumatology · doi:10.1186/1546-0096-12-s1-p53 · Cited by 26 · see citing works

11‐Month‐Old Infant With Periodic Fevers, Recurrent Liver Dysfunction, and Perforin Gene Polymorphism

Schulert, G. S., Bove, K. E., McMasters, R. L., Campbell, K. M., Leslie, N., & Grom, A. A. (2014) · Arthritis Care & Research · doi:10.1002/acr.22527 · Cited by 26 · see citing works

Novel Swine-Origin Influenza A (H1N1) Virus-Associated Hemophagocytic Syndrome—A First Case Report

Zheng, Y., Yang, Y., Zhao, W., & Wang, H. (2010) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2010.09-0666 · Cited by 21 · see citing works

Hemophagocytic Lymphohistiocytosis Associated With 2009 Pandemic Influenza A (H1N1) Virus Infection

Özdemir, H., Çi̇ftçi̇, E., İnce, E., Ertem, M., İnce, E., & Doğru, Ü. (2011) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181f46baf · Cited by 21 · see citing works

Report of a Fatal Pediatric Case of Hemophagocytic Lymphohistiocytosis Associated with Pandemic Influenza A (H1N1) Infection in 2009

Shrestha, B., Omran, A. G., Rong, P., & Wang, W. (2013) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2013.03.006 · Cited by 19 · see citing works

Hematological consequences of pandemic influenza H1N1 infection: a single center experience

Ünal, Ş., Gökçe, M., Aytaç, S., Karabulut, E., Altan, İ., Parlakay, A. Ö., Kara, A., Ceyhan, M., Cengiz, A. B., Tuncer, M., et al. (2010) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2010.5067 · Cited by 16 · see citing works

Macrophage activation syndrome induced by A/H1N1 influenza in cystic fibrosis

Casciaro, R., Cresta, F., Favilli, F., Naselli, A., Alessandri, A. D., & Minicucci, L. (2013) · Pediatric Pulmonology · doi:10.1002/ppul.22778 · Cited by 13 · see citing works

Analysis of Fatal Cases of Pandemic Influenza A (H1N1) Virus Infections in Pediatric Patients with Leukemia

Yaman, Y., Devrim, İ., Yeşim, O., Ayşen, T., Özek, G., Cartı, Ö., Meral, A. C., Güneş, B. T., Demirağ, B., Albudak, E., et al. (2013) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2013.796025 · Cited by 12 · see citing works

Cytokine storm

Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196 · see citing works

Cytokine storms: understanding COVID-19

Mangalmurti, N., & Hunter, C. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.017 · Cited by 698 · see citing works

COVID-19: Immunology and treatment options

Felsenstein, S., Herbert, J. A., McNamara, P. S., & Hedrich, C. M. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108448 · Cited by 669 · see citing works

The Immunology of Macrophage Activation Syndrome

Crayne, C. B., Albeituni, S., Nichols, K. E., & Cron, R. Q. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00119 · Cited by 633 · see citing works

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

Henderson, L. A., Canna, S., Schulert, G. S., Volpi, S., Lee, P. Y., Kernan, K. F., Caricchio, R., Mahmud, S. A., Hazen, M. M., Halyabar, O., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41285 · Cited by 633 · see citing works

Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome

Weiss, E. S., Girard-Guyonvarc’h, C., Holzinger, D., de Jesus, A. A., Tariq, Z., Picarsic, J. L., Schiffrin, E. J., Foell, D., Grom, A. A., Ammann, S., et al. (2018) · Blood · doi:10.1182/blood-2017-12-820852 · Cited by 396 · see citing works

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era

Behrens, E. M., & Koretzky, G. A. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40071 · Cited by 304 · see citing works

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis

Karakike, E., & Giamarellos‐Bourboulis, E. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00055 · Cited by 304 · see citing works

Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome

Mehta, P., Cron, R. Q., Hartwell, J., Manson, J. J., & Tattersall, R. S. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30096-5 · Cited by 287 · see citing works

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

Copaescu, A. M., Smibert, O. C., Gibson, A., Phillips, E. J., & Trubiano, J. A. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.001 · Cited by 258 · see citing works

Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

Torres Acosta, M. A., & Singer, B. D. (2020) · European Respiratory Journal · doi:10.1183/13993003.02049-2020 · Cited by 247 · see citing works

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility

Wang, F., Huang, S., Gao, R., Zhou, Y., Lai, C., Li, Z., Xian, W., Qian, X., Li, Z., Huang, Y., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-00231-4 · Cited by 222 · see citing works

Systemic Juvenile Idiopathic Arthritis–Associated Lung Disease: Characterization and Risk Factors

Schulert, G. S., Yasin, S., Carey, B. C., Chalk, C., Do, T., Schapiro, A. H., Husami, A., Watts, A., Brunner, H. I., Huggins, J., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41073 · Cited by 212 · see citing works

Macrophage Activation Syndrome

Ravelli, A., Davì, S., Minoia, F., Martini, A., & Cron, R. Q. (2015) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.06.010 · Cited by 211 · see citing works

Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities

Brisse, E., Wouters, C. H., & Matthys, P. (2016) · British Journal of Haematology · doi:10.1111/bjh.14147 · Cited by 197 · see citing works

Natural Killer Cell Dysfunction and Its Role in COVID-19

van Eeden, C., Khan, L., Osman, M. S., & Tervaert, J. W. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176351 · Cited by 172 · see citing works

Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management

Henderson, L. A., & Cron, R. Q. (2019) · Pediatric Drugs · doi:10.1007/s40272-019-00367-1 · Cited by 168 · see citing works

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome

Bracaglia, C., Prencipe, G., & Benedetti, F. D. (2017) · Pediatric Rheumatology · doi:10.1186/s12969-016-0130-4 · Cited by 160 · see citing works

Cytokine Storm Syndrome

Cron, R. Q., Goyal, G., & Chatham, W. W. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042921-112837 · Cited by 149 · see citing works

Calming the cytokine storm in COVID-19

Cron, R. Q., Caricchio, R., & Chatham, W. W. (2021) · Nature Medicine · doi:10.1038/s41591-021-01500-9 · Cited by 136 · see citing works

SARS-CoV-2 Infection–Associated Hemophagocytic Lymphohistiocytosis

Prilutskiy, A., Kritselis, M. A., Shevtsov, A., Yambayev, I., Vadlamudi, C., Zhao, Q., Kataria, Y., Sarosiek, S., Lerner, A., Sloan, J. M., et al. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa124 · Cited by 130 · see citing works

The Rheumatologist’s Role in COVID-19

Cron, R. Q., & Chatham, W. W. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.200334 · Cited by 123 · see citing works

Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID‐19: A Case Series

Navarro-Millán, I. Y., Sattui, S. E., Lakhanpal, A., Zisa, D., Siegel, C. H., & Crow, M. K. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41422 · Cited by 119 · see citing works

Immune cartography of macrophage activation syndrome in the COVID-19 era

McGonagle, D., Ramanan, A. V., & Bridgewood, C. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00571-1 · Cited by 117 · see citing works

Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome

Halyabar, O., Chang, M. H., Schoettler, M. L., Schwartz, M. A., Barış, H. E., Benson, L. A., Biggs, C. M., Gorman, M., Lehmann, L., Lo, M. S., et al. (2019) · Pediatric Rheumatology · doi:10.1186/s12969-019-0309-6 · Cited by 108 · see citing works

Blocking IL-1 to prevent respiratory failure in COVID-19

van de Veerdonk, F. L., & Netea, M. G. (2020) · Critical Care · doi:10.1186/s13054-020-03166-0 · Cited by 105 · see citing works

A Heterozygous <i>RAB27A</i> Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis

Zhang, M., Bracaglia, C., Prencipe, G., Bemrich-Stolz, C. J., Beukelman, T., Dimmitt, R. A., Chatham, W. W., Zhang, K., Li, H., Walter, M. R., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501284 · Cited by 99 · see citing works

Approaching hemophagocytic lymphohistiocytosis

Chinnici, A., Beneforti, L., Pegoraro, F., Trambusti, I., Tondo, A., Favre, C., Coniglio, M. L., & Sieni, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1210041 · Cited by 99 · see citing works

Virus‐triggered secondary hemophagocytic lymphohistiocytosis

Imashuku, S., Morimoto, A., & Ishii, E. (2021) · Acta Paediatrica · doi:10.1111/apa.15973 · Cited by 98 · see citing works

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

Morris, G., Bortolasci, C. C., Puri, B. K., Marx, W., O'Neil, A. E., Athan, E., Walder, K. R., Berk, M., OLIVE, L. S., Carvalho, A. F., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155593 · Cited by 97 · see citing works

Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect

Carvelli, J., Pipéroglou, C., Farnarier, C., Vely, F., Mazodier, K., Audonnet, S., Nitschké, P., Bôle‐Feysot, C., Boucékine, M., Cambon, A., et al. (2020) · Blood · doi:10.1182/blood.2019003664 · Cited by 94 · see citing works

The genetics of macrophage activation syndrome

Schulert, G. S., & Cron, R. Q. (2020) · Genes &amp; Immunity · doi:10.1038/s41435-020-0098-4 · Cited by 91 · see citing works

The use of anakinra in the treatment of secondary hemophagocytic lymphohistiocytosis

Bami, S., Vagrecha, A., Soberman, D., Badawi, M., Cannone, D., Lipton, J. M. M., Cron, R. Q., & Levy, C. F. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28581 · Cited by 92 · see citing works

The Effects of COVID-19 on the Placenta During Pregnancy

Sadeghirad, H., Röhl, J., Stylianou, N., Allenby, M. C., Bazaz, S. R., Warkiani, M. E., Souza-Fonseca-Guimarães, F., Clifton, V. L., & Kulasinghe, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.743022 · Cited by 92 · see citing works

Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overview

Khosroshahi, L. M., Rokni, M., Mokhtari, T., & Noorbakhsh, F. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107364 · Cited by 87 · see citing works

Convergent pathways of the hyperferritinemic syndromes

Schulert, G. S., & Canna, S. (2018) · International Immunology · doi:10.1093/intimm/dxy012 · Cited by 77 · see citing works

Humoral immune mechanisms involved in protective and pathological immunity during COVID-19

Widjaja, G., Jalil, A. T., Rahman, H. S., Abdelbasset, W. K., Bokov, D. O., Suksatan, W., Ghaebi, M., Marofi, F., Navashenaq, J. G., Jadidi‐Niaragh, F., et al. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.06.011 · Cited by 75 · see citing works

Highways to hell: Mechanism-based management of cytokine storm syndromes

Canna, S., & Cron, R. Q. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.09.016 · Cited by 73 · see citing works

Invasive pulmonary aspergillosis associated with viral pneumonitis

Dewi, I. M. W., Janssen, N. A. F., Rosati, D., Bruno, M., Netea, M. G., Brüggemann, R. J. M., Verweij, P. E., & van de Veerdonk, F. L. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.04.006 · Cited by 73 · see citing works

Systemic juvenile idiopathic arthritis and macrophage activation syndrome: update on pathogenesis and treatment

Yasin, S., & Schulert, G. S. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000526 · Cited by 69 · see citing works

Pathogenic Gene Mutations or Variants Identified by Targeted Gene Sequencing in Adults With Hemophagocytic Lymphohistiocytosis

Miao, Y., Zhu, H., Qiao, C., Xia, Y., Kong, Y.-L., Zou, Y., Miao, Y., Chen, X., Cao, L., Wu, W., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00395 · Cited by 69 · see citing works

Pediatric macrophage activation syndrome, recognizing the tip of the Iceberg

Crayne, C. B., & Cron, R. Q. (2019) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2019.19150 · Cited by 67 · see citing works

Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection

Lalueza, A., Ayuso, B., Arrieta, E., Trujillo, H., Folgueira, D., Cueto-Felgueroso, C., Serrano, A., Laureiro, J., Arévalo-Cañas, C., Castillo, C. G., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.02.018 · Cited by 66 · see citing works

Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Minoia, F., Bovis, F., Davì, S., Insalaco, A., Lehmberg, K., Shenoi, S., Weitzman, S. S., Espada, G., Gao, Y., Antón, J., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.06.005 · Cited by 65 · see citing works

Immune Mechanisms in Inflammatory Anemia

Canny, S. P., Orozco, S. L., Thulin, N. K., & Hamerman, J. A. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-125839 · Cited by 65 · see citing works

Natural Killer Cells in Systemic Autoinflammatory Diseases: A Focus on Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome

Vandenhaute, J., Wouters, C. H., & Matthys, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03089 · Cited by 65 · see citing works

Treatment and Mortality of Hemophagocytic Lymphohistiocytosis in Adult Critically Ill Patients: A Systematic Review With Pooled Analysis

Knaak, C., Schuster, F. S., Nyvlt, P., Spies, C., Feinkohl, I., Beutel, G., Schenk, T., Rosée, P. G. L., Janka, G., Brunkhorst, F. M., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004581 · Cited by 59 · see citing works

ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKL

Malireddi, R. K. S., Sharma, B. R., Bynigeri, R. R., Wang, Y., Lu, J., & Kanneganti, T. (2023) · Viruses · doi:10.3390/v15112141 · Cited by 57 · see citing works

Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients

Dulek, D. E., Fuhlbrigge, R. C., Tribble, A. C., Connelly, J. A., Loi, M. M., Chebib, H. E., Chandrakasan, S., Otto, W. R., Diorio, C. J., Keim, G. P., et al. (2020) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaa098 · Cited by 55 · see citing works

Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

Lega, S., Naviglio, S., Volpi, S., & Tommasini, A. (2020) · Vaccines · doi:10.3390/vaccines8020224 · Cited by 52 · see citing works

Cytokine storm and the prospects for immunotherapy with COVID-19

Calabrese, L. H. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.ccc008 · Cited by 51 · see citing works

Brief Report: Novel UNC13D Intronic Variant Disrupting an NF‐κB Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis

Schulert, G. S., Zhang, M., Husami, A., Fall, N., Brunner, H. I., Zhang, K., Cron, R. Q., & Grom, A. A. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40438 · Cited by 51 · see citing works

Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches

Han, S. B., & Lee, S. Y. (2020) · World Journal of Pediatrics · doi:10.1007/s12519-020-00360-6 · Cited by 47 · see citing works

Hemophagocytic Lymphohistiocytosis Gene Variants in Multisystem Inflammatory Syndrome in Children

Vagrecha, A., Zhang, M., Acharya, S. S., Lozinsky, S., Singer, A. M., Levine, C., Al‐Ghafry, M., Levy, C. F., & Cron, R. Q. (2022) · Biology · doi:10.3390/biology11030417 · Cited by 45 · see citing works

Adults with septic shock and extreme hyperferritinemia exhibit pathogenic immune variation

Kernan, K. F., Ghaloul‐Gonzalez, L., Shakoory, B., Kellum, J. A., Angus, D. C., & Carcillo, J. A. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0030-3 · Cited by 45 · see citing works

Pathogenesis and Treatment of Refractory Disease Courses in Systemic Juvenile Idiopathic Arthritis

Erkens, R. G. A., Esteban, Y., Towe, C. T., Schulert, G. S., & Vastert, S. J. (2021) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2021.06.003 · Cited by 45 · see citing works

Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation

Tsoukas, P., Rapp, E., Kraak, L. V. D., Weiss, E. S., Dang, V., Schneider, C., Klein, E. C., Picarsic, J. L., Salcedo, R., Stewart, C. A., et al. (2020) · Blood · doi:10.1182/blood.2019003846 · Cited by 39 · see citing works

Hemophagocytic Lymphohistiocytosis and Infection: A Literature Review

Koumadoraki, E., Madouros, N., Sharif, S., Saleem, A., Jarvis, S., & Khan, S. (2022) · Cureus · doi:10.7759/cureus.22411 · Cited by 38 · see citing works

Fatal COVID-19 infections: Is NK cell dysfunction a link with autoimmune HLH?

Osman, M. S., van Eeden, C., & Tervaert, J. W. C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102561 · Cited by 37 · see citing works

The critical impacts of cytokine storms in respiratory disorders

Tramboo, S. R., Elkhalifa, A. M. E., Khursheed, S. Q., Ali, S. I., Shah, N. N., Taifa, S., Rakhshan, R., Shah, I. H., Mir, M. A., Malik, M., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29769 · Cited by 31 · see citing works

Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression

Rocco, J. M., Laidlaw, E., Galindo, F., Anderson, M. V., Rupert, A. W., Higgins, J. M., Sortino, O., Ortega‐Villa, A. M., Sheikh, V., Roby, G. A., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac717 · Cited by 33 · see citing works

Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children

Schulert, G. S., Blum, S. A., & Cron, R. Q. (2021) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001061 · Cited by 31 · see citing works

The Multifaceted Immunology of Cytokine Storm Syndrome

Lee, P. Y., & Cron, R. Q. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200808 · Cited by 32 · see citing works

Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19

Agarwal, S., & June, C. H. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0473 · Cited by 30 · see citing works

Severe adult hemophagocytic lymphohistiocytosis (HLHa) correlates with HLH-related gene variants

Bloch‐Queyrat, C., Jaïs, J., Gil, M., Boubaya, M., Lepelletier, Y., Bader‐Meunier, B., Mahlaoui, N., Garcelon, N., Lambotte, O., Launay, D., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.07.023 · Cited by 30 · see citing works

COVID-19 and Hyperinflammatory Syndrome in Children: Kawasaki Disease with Macrophage Activation Syndrome in Disguise?

Loomba, R. S., Villarreal, E. G., & Flores, S. (2020) · Cureus · doi:10.7759/cureus.9515 · Cited by 27 · see citing works

Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: Diagnostic Challenges and Determinants of Outcome

Kurver, L., Seers, T., van Dorp, S., van Crevel, R., Pollara, G., & van Laarhoven, A. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad697 · Cited by 26 · see citing works

All Patients With Common Variable Immunodeficiency Disorders (CVID) Should Be Routinely Offered Diagnostic Genetic Testing

Ameratunga, R., Lehnert, K., & Woon, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02678 · Cited by 27 · see citing works

Perforin, COVID‐19 and a possible pathogenic auto‐inflammatory feedback loop

Cunningham, L., Kimber, I., Basketter, D. A., Peter Simmonds, K., McSweeney, S. M., Tziotzios, C., & McFadden, J. P. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13102 · Cited by 27 · see citing works

A novel prognostic model for adult patients with Hemophagocytic Lymphohistiocytosis

Zhou, J., Zhou, J., Wu, Z.-Q., Goyal, H., & Xu, H. (2020) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-020-01496-4 · Cited by 26 · see citing works

Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis

Kernan, K. F., Ghaloul‐Gonzalez, L., Vockley, J. E., Lamb, J., Hollingshead, D. J., Chandran, U. R., Sethi, R., Park, H. J., Berg, R. A., WESSEL, D. L., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01183-4 · Cited by 25 · see citing works

Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm

You, J., Li, H., Fan, P., Yang, X., Wei, Y., Zheng, L., Li, Z. S., & Cheng, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853496 · Cited by 23 · see citing works

Macrophage Activation Syndrome

Eloseily, E. M., & Cron, R. Q. (2018) · Springer eBooks · doi:10.1007/978-3-319-79026-8_14 · Cited by 26 · see citing works

A male infant with COVID‐19 in the context of ARPC1B deficiency

Castaño‐Jaramillo, L. M., Yamazaki‐Nakashimada, M. A., Scheffler‐Mendoza, S., Bustamante‐Ogando, J. C., Espinosa‐Padilla, S. E., & Reyes, S. O. L. (2020) · Pediatric Allergy and Immunology · doi:10.1111/pai.13322 · Cited by 22 · see citing works

COVID-19-associated secondary hemophagocytic lymphohistiocytosis (cytokine storm syndrome)

Alexeeva, E. I., Фаридович, Т. Р., Shilkrot, I. Y., Dvoryakovskaya, T. M., Surkov, A. G., & Алексеевич, К. И. (2021) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn1410 · Cited by 28 · see citing works

Perforin gene variant A91V in young patients with severe COVID-19.

Cabrera-Marante, Ó., de Frías, E. R., Pleguezuelo, D. E., Allende, L. M., Serrano, A., Laguna‐Goya, R., Mancebo, E., Talayero, P., Álvarez‐Vallina, L., Morales, P., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.260307 · Cited by 22 · see citing works

Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis

Lim, S. S., Tasian, S. K., Bassiri, H., Fisher, B. T., Atalla, J. E., Patel, R., Romberg, N. D., Lambert, M. P., Paessler, M. E., Behrens, E. M., et al. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01025-3 · Cited by 22 · see citing works

Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis

Schotthoefer, A. M., Schrodi, S. J., Meece, J. K., Fritsche, T. R., & Shukla, S. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179655 · Cited by 22 · see citing works

Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis

Marques, M. C., Rubin, D., Shuldiner, E. G., Datta, M., Schmitz, E. G., Cruz, G. G., Patt, A., Bennett, E., Grom, A. A., Foell, D., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42938 · Cited by 21 · see citing works

Inmunosupresión en el trasplante hepático en la era covid-19

Forns, X., & Navasa, M. (2020) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2020.06.003 · Cited by 20 · see citing works

Dilemmas in diagnosis and management of hemophagocytic lymphohistiocytosis in children

Xu, X., & Tang, Y. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00299-3 · Cited by 20 · see citing works

Coronavirus is the trigger, but the immune response is deadly

Cron, R. Q. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30165-x · Cited by 20 · see citing works

The mechanistic basis linking cytokine storm to thrombosis in COVID-19

Wolf, A. J., Khimani, F., Yoon, B., Gerhart, C. R. B., Endsley, D., Ray, A., Yango, A. F., Flynn, S. D., Lip, G. Y. H., Gonzalez, S. A., et al. (2022) · Thrombosis Update · doi:10.1016/j.tru.2022.100110 · Cited by 18 · see citing works

Macrophage Activation Syndrome in Viral Sepsis

Papageorgiou, D., Gogos, C. A., & Akinosoglou, K. (2024) · Viruses · doi:10.3390/v16071004 · Cited by 18 · see citing works

Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection

Lalueza, A., Trujillo, H., Laureiro, J., García, B. A., Hernández-Jiménez, P., Castillo, C. G., Torres, M., Folgueira, M. D., Madrid, O., Díaz‐Pedroche, C., et al. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-2998-4 · Cited by 18 · see citing works

The role of the allergist/immunologist in the COVID-19 pandemic: A Janus-faced presentation

Bellanti, J. A. (2020) · Allergy and Asthma Proceedings · doi:10.2500/aap.2020.41.200072 · Cited by 18 · see citing works

A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm Syndrome

Reiff, D. D., Zhang, M., Smitherman, E. A., Mannion, M. L., Stoll, M. L., Weiser, P., & Cron, R. Q. (2022) · Life · doi:10.3390/life12020149 · Cited by 17 · see citing works

Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes

Rocco, J. M., Laidlaw, E., Galindo, F., Anderson, M., Sortino, O., Kuriakose, S., Lisco, A., Manion, M. M., & Sereti, I. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad059 · Cited by 17 · see citing works

Community-acquired methicillin-resistant Staphylococcus aureus provoked cytokine storm causing severe infection on BALB/c mice

Liao, F., Gu, W., Fu, X., Yuan, B., & Zhang, Y. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.10.013 · Cited by 16 · see citing works

Innate immunity in rickettsial infections

Londoño, A. F., Scorpio, D. G., & Dumler, J. S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1187267 · Cited by 16 · see citing works

Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation

Landy, E., Varghese, J., Dang, V., Szymczak-Workman, A. L., Kane, L., & Canna, S. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010502 · Cited by 16 · see citing works

The immunologic features of patients with early-onset and polyautoimmunity

Hoyt, K. J., Chatila, T. A., Notarangelo, L. D., Hazen, M. M., Janssen, E., & Henderson, L. A. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.108326 · Cited by 16 · see citing works

Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis

Chu, R., van Eeden, C., Suresh, S., Sligl, W., Osman, M. S., & Tervaert, J. W. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062967 · Cited by 15 · see citing works

Infection-associated Hemophagocytic Syndrome in Critically Ill Patients with COVID-19

YANG, K. Y., Xing, M., Jiang, L., Cai, Y., Yang, L., Xie, N., Chen, J., Wang, W., Wang, L., Zhu, J., et al. (2021) · Current Medical Science · doi:10.1007/s11596-021-2315-4 · Cited by 14 · see citing works

Hemophagocytic Lymphohistiocytosis in the Emergency Department: Recognizing and Evaluating a Hidden Threat

Morrissette, K. M., Bridwell, R. E., Lentz, S. A., Brem, E. A., Gutierrez, K. O., Singh, M., Koyfman, A., & Long, B. (2021) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2021.02.006 · Cited by 14 · see citing works

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges

Masterson, C. H., Ceccato, A., Artigas, A., dos Santos, C. C., Rocco, P. R. M., Enes, S. R., Weiss, D. J., McAuley, D. F., Matthay, M. A., English, K., et al. (2021) · Intensive Care Medicine Experimental · doi:10.1186/s40635-021-00424-5 · Cited by 12 · see citing works

Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study

Taher, J., Mighton, C. E., Chowdhary, S., Casalino, S., Frangione, E., Arnoldo, S., Bearss, E., Binnie, A., Bombard, Y., Borgundvaag, B., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-052842 · Cited by 12 · see citing works

Biologic disease-modifying antirheumatic drugs to treat multisystem inflammatory syndrome in children

Cron, R. Q. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000889 · Cited by 11 · see citing works

Perforin and resistance to SARS coronavirus 2

Cunningham, L., Peter Simmonds, K., Kimber, I., Basketter, D. A., & McFadden, J. P. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.007 · Cited by 11 · see citing works

Pediatric hemophagocytic lymphohistiocytosis: current conceptualization, diagnosis, and treatment

Verkamp, B., Jordan, M. B., & Allen, C. E. (2026) · Blood · doi:10.1182/blood.2025028762 · Cited by 10 · see citing works

Research brief

Mohammadi, D. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00497-1

Fulminant hemophagocytic lymphohistiocytosis induced by pandemic A (H1N1) influenza: a case report

Willekens, C., Cornélius, A., Guerry, M., Wacrenier, A., & Fourrier, F. (2011) · Journal of Medical Case Reports · doi:10.1186/1752-1947-5-280 · Cited by 22 · see citing works

Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature

Lai, S., Merritt, B. Y., Chen, L., Zhou, X., & Green, L. (2011) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2011.03.009 · Cited by 29 · see citing works

Report of a Fatal Pediatric Case of Hemophagocytic Lymphohistiocytosis Associated with Pandemic Influenza A (H1N1) Infection in 2009

Shrestha, B., Omran, A. G., Rong, P., & Wang, W. (2013) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2013.03.006 · Cited by 19 · see citing works

A Case of H1N1 Influenza A-Associated Hemophagocytic Lymphohistiocytosis

Lairet, S., Suaris, M., Ladd, B. F., & Hernandez-Trujillo, V. P. (2021) · American Academy of Pediatrics Section on Pediatric Trainees Program · doi:10.1542/peds.147.3_meetingabstract.843