The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.
Open accessAbstract
BACKGROUND: Long-lasting protection resulting from hepatitis B vaccine, despite loss of antibody against hepatitis B virus (HBV) surface antigen (anti-HBs), is undetermined. METHODS: We recruited persons from a cohort vaccinated with plasma-derived hepatitis B vaccine in 1981 who have been followed periodically since. We performed serological testing for anti-HBs and microRNA-155 and assessed HBV-specific T-cell responses by enzyme-linked immunospot and cytometric bead array. Study subgroups were defined 32 years after vaccination as having an anti-HBs level of either ≥10 mIU/mL (group 1; n = 13) or <10 mIU/mL (group 2; n = 31). RESULTS: All 44 participants, regardless of anti-HBs level, tested positive for tumor necrosis factor α, interleukin 10, or interleukin 6 production by HBV surface antigen-specific T cells. The frequency of natural killer T cells correlated with the level of anti-HBs (P = .008). The proportion of participants who demonstrated T-cell responses to HBV core antigen varied among the cytokines measured, suggesting some natural exposure to HBV in the study group. No participant had evidence of breakthrough HBV infection. CONCLUSIONS: Evidence of long-lasting cellular immunity, regardless of anti-HBs level, suggests that protection afforded by primary immunization with plasma-derived hepatitis B vaccine during childhood and adulthood lasts at least 32 years.
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“Vaccine-induced immune memory has been demonstrated to persist for >30 years (1325–1327).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1327]
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- Werner, 2013, Innate and adaptive immune responses correlate to antibody recall responses to hepatitis B booster vaccineation, Hepatology, 58, 612A
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Anti-HBs Concentrations and Post-Booster Serological Response Among Romanian Dental Students
Borcoș, B. R., Merişescu, M. M., Totoianu, A., Nedelcu, R., Gheorghe, E., & Jugulete, G. (2026) · Vaccines · doi:10.3390/vaccines14110917
Metadata
- Authors
- Simons, B. C., Spradling, P. R., Bruden, D. J. T., Zanis, C., Case, S., Choromanski, T. L., Apodaca, M., Brogdon, H. D., Dwyer, G., Snowball, M., Negus, S., Bruce, M. G., Morishima, C., Knall, C., & McMahon, B. J.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Alaska Native Tribal Health Consortium (US)
- University of Washington (US)
- University of Alaska Anchorage (US)
- Corresponding author
- Simons, Brenna C.
- ORCID
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-04-07
- Volume
- 214
- Issue
- 2
- Pages
- 273-280
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC4918827
- OpenAlex
- W2359724621
- Cited by
- 101
- References
- 50
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 16 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 1
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- CDC (U01 PS001097)
- National Institute of General Medical Sciences
- National Institutes of Health
- NIH (P20GM103395, U261IHS0046)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Keywords
- hepatitis B vaccine, hepatitis B virus, cell-mediated immunity, hepatitis B surface antigen, HBV core antigen, NKT cells, cytokine production, miR-155, plasma-derived vaccine
- MeSH terms
- Adult, Cytological Techniques, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Immunity, Cellular, Longitudinal Studies, Male, Middle Aged, T-Lymphocytes, Time Factors, Hepatitis B Vaccines, MicroRNAs, Enzyme-Linked Immunospot Assay
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