Cited by 101Hepatitis B Virus StudiesHepatitis C virus researchIntramuscular injections and effects

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.

Open access

Simons, Brenna C., Spradling, Philip R., Bruden, Dana J. T., Zanis, Carolyn, Case, Samantha, Choromanski, Tammy L., Apodaca, Minjun, Brogdon, Hazel D., Dwyer, Gaelen, Snowball, Mary, Negus, Susan, Bruce, Michael G., Morishima, Chihiro, Knall, Cindy, McMahon, Brian J.·2016·Journal of Infectious Diseases

DOI 10.1093/infdis/jiw142PMC PMC4918827

Open this paper in CoChat — free account

Abstract

BACKGROUND: Long-lasting protection resulting from hepatitis B vaccine, despite loss of antibody against hepatitis B virus (HBV) surface antigen (anti-HBs), is undetermined. METHODS: We recruited persons from a cohort vaccinated with plasma-derived hepatitis B vaccine in 1981 who have been followed periodically since. We performed serological testing for anti-HBs and microRNA-155 and assessed HBV-specific T-cell responses by enzyme-linked immunospot and cytometric bead array. Study subgroups were defined 32 years after vaccination as having an anti-HBs level of either ≥10 mIU/mL (group 1; n = 13) or <10 mIU/mL (group 2; n = 31). RESULTS: All 44 participants, regardless of anti-HBs level, tested positive for tumor necrosis factor α, interleukin 10, or interleukin 6 production by HBV surface antigen-specific T cells. The frequency of natural killer T cells correlated with the level of anti-HBs (P = .008). The proportion of participants who demonstrated T-cell responses to HBV core antigen varied among the cytokines measured, suggesting some natural exposure to HBV in the study group. No participant had evidence of breakthrough HBV infection. CONCLUSIONS: Evidence of long-lasting cellular immunity, regardless of anti-HBs level, suggests that protection afforded by primary immunization with plasma-derived hepatitis B vaccine during childhood and adulthood lasts at least 32 years.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/infdis/jiw142

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Biology of NKT Cells
Bendelac, A. S., Savage, P. B., & Teyton, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141711 · Cited by 2,169
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547
Hepatitis B Vaccine
Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Oleszko, W. R., William, D. C., D, R. S. M., Morrison, J. M., & Kellner, A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010093031501 · Cited by 1,117
PREVENTION OF PERINATALLY TRANSMITTED HEPATITIS B VIRUS INFECTIONS WITH HEPATITIS B IMMUNE GLOBULIN AND HEPATITIS B VACCINE
Beasley, R. P., LEE, G. C.-Y., Roan, C., Hwang, L., Lan, C., Huang, F.-Y., & Chen, C.-L. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90624-4 · Cited by 815
Long-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual Men
Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Echenberg, D. F., Ostrow, D. G., OʼMalley, P. M., Penley, K. A., Altman, N. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150401 · Cited by 608
MATERNAL DEATHS
Newcombe, R. G. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90482-1 · Cited by 546
microRNAs and the immune response
Lindsay, M. A. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.04.004 · Cited by 475
Antibody levels and protection after hepatitis B vaccine: results of a 30-year follow-up study and response to a booster dose.
Bruce, M. G., Bruden, D., Hurlburt, D., Zanis, C., Thompson, G., Rea, L., Toomey, M., Townshend-Bulson, L., Rudolph, K., Bulkow, L., et al. (2016) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv748 · Cited by 322
Antibody Levels and Protection after Hepatitis B Vaccination: Results of a 15-Year Follow-up
McMahon, B. J., Bruden, D. L., Petersen, K. M., BULKOW, L. R., Parkinson, A. J., Nainan, O. V., Khristova, M. L., Zanis, C. L., Peters, H. V., & Margolis, H. S. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-5-200503010-00008 · Cited by 315

Show all 50 references

Research works printed but not linked: 2

10.1001/archinte.1991.00400080118023 · DOI
Werner, 2013, Innate and adaptive immune responses correlate to antibody recall responses to hepatitis B booster vaccineation, Hepatology, 58, 612A

Sorted by citations

Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Prevention of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices.
Schillie, S., Vellozzi, C., Reingold, A., Harris, A., Haber, P., Ward, J. W., & Nelson, N. P. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6701a1 · Cited by 815
Hepatitis B Vaccines
Pattyn, J., Hendrickx, G., Vorsters, A., & Damme, P. V. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa668 · Cited by 328
Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention
Abara, W. E., Qaseem, A., Schillie, S. F., McMahon, B. J., & Harris, A. M. (2017) · Annals of Internal Medicine · doi:10.7326/m17-1106 · Cited by 150
Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?
Connell, A. R., Connell, J., Leahy, T. R., & Hassan, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02089 · Cited by 73
Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents
Duque, J. S. R., Wang, X., Leung, D., Cheng, S. M. S., Cohen, C. A., Mu, X., Hachim, A., Zhang, Y., Chan, S. M., Chaothai, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31485-z · Cited by 60
Protection and antibody levels 35 years after primary series with hepatitis B vaccine and response to a booster dose
Bruce, M. G., Bruden, D. J. T., Hurlburt, D. A., Morris, J. M., Bressler, S. S., Thompson, G. G., Lecy, D., Rudolph, K. M., BULKOW, L. R., Hennessy, T., et al. (2022) · Hepatology · doi:10.1002/hep.32474 · Cited by 59
Insights into induction of the immune response by the hepatitis B vaccine
Lello, F. A. D., Martínez, A. P., & Flichman, D. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4249 · Cited by 53
Persistence of HB sAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults
Damme, P. V., Dionne, M., Leroux-Roels, G. G., Meeren, O. V. D., Paolo, E. D., Salaun, B., Kiran, P. S., & Folschweiller, N. (2019) · Journal of Viral Hepatitis · doi:10.1111/jvh.13125 · Cited by 47
ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease
Farraye, F. A., Melmed, G., Lichtenstein, G. R., Barnes, E. L., Limketkai, B. N., Caldera, F., & Kane, S. V. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003541 · Cited by 44
Reduced immune responses to hepatitis B primary vaccination in obese individuals with nonalcoholic fatty liver disease (NAFLD)
Joshi, S. S., Davis, R. P., Ma, M. M., Tam, E., Cooper, C., Ramji, A. S., Kelly, E., Jayakumar, S., Swain, M. G., Jenne, C. N., et al. (2021) · npj Vaccines · doi:10.1038/s41541-020-00266-4 · Cited by 28
Duration of Hepatitis B Vaccine-Induced Protection among Medical Students and Healthcare Workers following Primary Vaccination in Infancy and Rate of Immunity Decline
Phattraprayoon, N., Kakheaw, J., Soonklang, K., Cheirsilpa, K., Ungtrakul, T., Auewarakul, C. U., & Mahanonda, N. (2022) · Vaccines · doi:10.3390/vaccines10020267 · Cited by 24
Revaccination against hepatitis B in late teenagers who received vaccination during infancy: Yes or no?
Zhao, H. L., & Zhou, Y. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1397243 · Cited by 23
CSOG MFM Committee Guideline: Management of Hepatitis B During Pregnancy and Prevention of Mother-to-Child Transmission of Hepatitis B Virus (2020)
Zhou, Y., Hu, Y., Liu, X., & Yang, H. (2021) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000087 · Cited by 22
Physicians’ Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the Study of Inflammatory Bowel Disease
Macaluso, F. S., Mazzola, G. C., Ventimiglia, M., Alvisi, P., Renna, S., Adamoli, L., Galli, M., Armuzzi, A., Ardizzone, S., Cascio, A., et al. (2019) · Digestion · doi:10.1159/000500798 · Cited by 20
Assessing the Cost-Utility of Universal Hepatitis B Vaccination Among Adults
Hall, E. W., Weng, M. K., Harris, A. M., Schillie, S. F., Nelson, N. P., Ortega‐Sanchez, I. R., Rosenthal, E. M., Sullivan, P. S., Lopman, B. A., Jones, J. S., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac088 · Cited by 19
Malaria vaccines: facing unknowns
Palacpac, N., & Horii, T. (2020) · F1000Research · doi:10.12688/f1000research.22143.1 · Cited by 17
Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease
Ulrich, J. A., Habash, N. W., Ismail, Y., Tremaine, W. J., Weaver, A. L., Murray, J. A., Loftus, E. V., & Absah, I. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.03.025 · Cited by 16
Hepatitis B Outcomes After Switching to Long-Acting Cabotegravir/Rilpivirine in People With HIV: Reactivation, Incident Infection, and Liver Safety Across Diverse Serological Profiles
Foncillas, A., Ambrosioni, J., Sempere, A., Berrocal, L., Calvo, J., Chivite, I., de la Mora, L., Inciarte, A., Torres, B., Martínez‐Rebollar, M., et al. (2026) · Clinical Infectious Diseases · doi:10.1093/cid/ciag023 · Cited by 15
Discordance of hepatitis B vaccination policies for healthcare workers between the USA, the UK, and Germany
Komatsu, H., Klenerman, P., & Thimme, R. (2019) · Hepatology Research · doi:10.1111/hepr.13470 · Cited by 15
Hepatitis B seroprevalence in 10-25-year-olds in Mexico - the 2012 national health and nutrition survey (ENSANUT) results
López‐Gatell, H., García‐García, L., Echániz-Avilés, G., Cruz‐Hervert, L. P., Olamendi-Portugal, M., Castaneda, D., Sánchez-Alemán, M. Á., Martínez, M. R., DeAntonio, R., Cervantes-Apolinar, M. Y., et al. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1533617 · Cited by 15
From infancy and beyond… ensuring a lifetime of hepatitis B virus (HBV) vaccine-induced immunity
Osiowy, C. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1462428 · Cited by 15
Will Infant Hepatitis B Vaccination Protect Into Adulthood?
Pinto, M., Dawar, M., Krajden, M., Naus, M., & Scheifele, D. W. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001543 · Cited by 13
Disparities in Hepatitis B Virus Infection and Immunity Among New York City Asian American Patients, 1997 to 2017
Tang, A. S., Lyu, J., Wang, S., He, Q., Pong, P., & Harris, A. M. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304504 · Cited by 13
Lasting benefit of infant hepatitis B vaccination in adolescents in the Lao People’s Democratic Republic
Hefele, L., Vannachone, S., Khounvisith, V., Nouanthong, P., Sayasone, S., Kounnavong, S., Chanthavilay, P., Muller, C. P., & Black, A. P. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.01.055 · Cited by 13
Observational study of vaccine effectiveness 20 years after the introduction of universal hepatitis B vaccination in Tunisia
Hadj, M. B., Bouguerra, H., Saffar, F., Chelly, S., Hechaichi, A., Talmoudi, K., Bahrini, A., Chouki, T., Hazgui, O., Hannachi, N., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.08.038 · Cited by 12
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro
Konopleva, M. V., Borisova, V. N., Sokolova, M. V., Семененко, Т. А., & Suslov, A. P. (2022) · Vaccines · doi:10.3390/vaccines10020235 · Cited by 12
Susceptibility to hepatitis B virus infection in adults living in Spain
Soriano, V., Aguilera, A., Benito, R., González‐Díez, R., Miró, E., Liendo, P., Rodrı́guez, J. C., Cabezas, T., Richart, A., Ramos, J. M., et al. (2023) · Liver International · doi:10.1111/liv.15548 · Cited by 11
Exploring the optimal vaccination strategy against hepatitis B virus in childhood (Review)
Kramvis, A., Mammas, I., & Spandidos, D. A. (2023) · Biomedical Reports · doi:10.3892/br.2023.1631 · Cited by 11
Incidences of new hepatitis B infection and anti‐hepatitis B core‐negative occult hepatitis B infection among Japanese blood donors in relation to anti‐hepatitis B surface antigen levels
Satake, M., Sugiyama, M., Mizokami, M., & Tanaka, J. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29823 · Cited by 9
Administering an additional hepatitis B vaccination dose after 18 years maintains adequate long-term protection levels in healthcare workers
Hess, L., Riesenberg, K., Rolston, K. V. I., & Nesher, L. (2020) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2020.1718201 · Cited by 9
Hepatitis B and pertussis antibodies in 4- to 5-year-old children previously vaccinated with different hexavalent vaccines
Vesikari, T., Xu, J. Z., Johnson, D. R., Hall, J. D., Marček, T., Goveia, M. G., Acosta, C. J., & Lee, A. W.-T. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1673119 · Cited by 9
Summary of the NACI Update on the Recommended Use of Hepatitis B Vaccine
Henry, B., & Baclic, O. (2017) · Canada Communicable Disease Report · doi:10.14745/ccdr.v43i05a04 · Cited by 8
Impact of universal infant hepatitis B vaccination in the US-affiliated Pacific Islands, 1985–2015
Abara, W. E., Collier, M. G., & Teshale, E. H. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.01.020 · Cited by 8
High Rates of Seroprotection to Hepatitis B After a Hepatitis B Challenge Dose in Previously Vaccinated Patients with Inflammatory Bowel Disease on Immunosuppressive Therapy
Ley, D., Lazarus, S. G., Forati, A. M., Farraye, F. A., Smith, R. A., Hayney, M. S., & Caldera, F. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08527-1 · Cited by 8
Will Infant Hepatitis B Immunization Protect Adults?
Scheifele, D. W. (2019) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002326 · Cited by 7
An Evidence-based Practical Guide to Vaccination for Hepatitis B Virus
Jacobson, I. M., Brown, R. S., McMahon, B. J., Perrillo, R. P., & Gish, R. G. (2022) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001695 · Cited by 7
Hepatitis B Virus in Polish Blood Donors in the Period 2005–2019—Significant Changes in Epidemiology and Demographic Characteristics of Infected Donors
Kopacz, A., Kubicka‐Russel, D., Liszewski, G., Sulkowska, E., Chrzanowska, A., Zwolińska, P., Noceń, E., Potępa, A., Łętowska, M., & Grabarczyk, P. (2025) · Viruses · doi:10.3390/v17010060 · Cited by 6
Minimal association of alleles of human leukocyte antigen class II gene and long-term antibody response to hepatitis B vaccine vaccinated during infancy
Xu, B., Zhu, D., Bi, Y., Wang, Y., Hu, Y., & Zhou, Y. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.03.021 · Cited by 6
Low Prevalence of Vaccination or Documented Immunity to Hepatitis A and Hepatitis B Viruses Among Individuals with Chronic Liver Disease
Wong, R. J., Gish, R. G., Cheung, R. C., & Chitnis, A. S. (2021) · The American Journal of Medicine · doi:10.1016/j.amjmed.2021.02.008 · Cited by 6
Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders
Vakili, M. E., Faghih, Z. S., Sarvari, J., Doroudchi, M., Hosseini, S. N., Kabelitz, D., & Kalantar, K. (2022) · Immunologic Research · doi:10.1007/s12026-022-09278-9 · Cited by 6
Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Tropical Medicine and Health · doi:10.1186/s41182-024-00594-4 · Cited by 6
Persistence of Anti-HB Antibodies in Healthcare Trainees: The Impact of Childhood Versus Adolescent Vaccination
Giampaolo, L. D., Coppeta, L., Borrelli, P., Astolfi, P., Resta, A., Loffredo, L., Bucchianico, F. D. M. D., Mangifesta, R., Ippoliti, L., & Ferrari, C. (2025) · Vaccines · doi:10.3390/vaccines13060562 · Cited by 5
Hepatitis B vaccination status in an at-risk adult population: long-term immunity but insufficient coverage
Hustache, S., Moyroud, L., Goirand, L., & Épaulard, O. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-2957-0 · Cited by 5
Hepatitis B Vaccines
Ward, J. W., Wanlapakorn, N., Poovorawan, Y., & Shouval, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00027-x · Cited by 5
Aplicación racional de las recomendaciones ESPGHAN 2022 de seguimiento del paciente celíaco pediátrico: documento de consenso de sociedades científicas (SEGHNP, AEPap, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG y SEMERGEN)
Román, E., Barrio, J., Cilleruelo, M. L., Torres, R., Almazán, V., Coronel, C., Espín, B., Martínez‐Ojinaga, E., Solís, D. P., Moreno, M. A. G., et al. (2024) · Anales de Pediatría · doi:10.1016/j.anpedi.2024.09.001 · Cited by 5
Towards the worldwide eradication of hepatitis B virus infection: A combination of prophylactic and therapeutic factors
Sagnelli, C., & Sagnelli, E. (2019) · World Journal of Clinical Infectious Diseases · doi:10.5495/wjcid.v9.i2.11 · Cited by 5
Clinical Trial: Immunogenicity of Double‐Dose Versus Standard‐Dose of Hepatitis B Virus Vaccine in Inflammatory Bowel Disease
Singh, A. K., Soni, R. K., Jearth, V., Yadav, A. I., Birda, C. L., Chatterjee, A., Shah, J., Mohindra, R., Patil, A. N., Suri, V., et al. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70470 · Cited by 4
Immune Responses to HBV Vaccine in People Living with HIV (PLWHs) Who Achieved Successful Treatment: A Prospective Cohort Study
Xu, L., Zhang, L., Kang, S., Li, X., Lu, L., Liu, X., Song, X., Li, Y., Li, X., Lyu, W., et al. (2023) · Vaccines · doi:10.3390/vaccines11020400 · Cited by 4
Induction of Innate and Adaptive Immune Response against Recombinant HBsAg Protein Entrapped in Docosahexaenoic Acid Nanovesicles through Biomarkers
Bakkari, M. A., Moni, S. S., Alshammari, A., Sultan, M. H., Madkhali, O. A. A., Almoshari, Y., Alam, M. F., & Elmobark, M. E. (2023) · Vaccines · doi:10.3390/vaccines11020457 · Cited by 4
Celiac Disease: Risk of Hepatitis B Infection.
Habash, N. W., Choung, R. S., Jacobson, R. M., Murray, J. A., & Absah, I. (2022) · PubMed · doi:10.1097/mpg.0000000000003362 · Cited by 3
Level of antibody to hepatitis B surface antigen declined below 10 mIU/ml is still protective
Shen, P., Xu, C., Li, T., Rui, Y., Hu, Y., Zhang, Y., & Zhou, Y. (2025) · npj Vaccines · doi:10.1038/s41541-025-01188-9 · Cited by 3
Demonstration of durable hepatitis B immune memory in children vaccinated with a DTaP5-IPV-HepB-Hib infant-toddler series 7 to 8 years previously
Ahonen, A., Zhang, Y., Marček, T., Lumley, J., Johnson, D. R., Güriş, D., & Wilck, M. B. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2073747 · Cited by 3
Post-vaccination Immunity Against Hepatitis B Among Mongolian Adolescents and Youths
Shagdarsuren, O.-E., Khuyagaa, S.-O., Mukhtar, Y., Mandakh, U., Enkh-Oyun, T., Shaarii, S., Batsuren, N., Namdag, B., Radnaa, O., & Dambadarjaa, D. (2022) · Hepatitis Monthly · doi:10.5812/hepatmon-121383 · Cited by 3
Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine: A Prospective Cohort Study
Liu, H., Li, L., Li, Y., Liu, M., Song, Y., Ding, F., Zhang, X., & Li, J. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00032s · Cited by 3
Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09201-7 · Cited by 3
A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers
Kiertscher, S. M., Gangalum, P. R., Ibrahim, G., Tashkin, D. P., & Roth, M. D. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9776-7 · Cited by 3
Longitudinal mapping of hepatitis B vaccine‐induced B‐cell linear epitopes in healthy individuals
Zhong, S., Liu, Z., Zhou, Y., Zhang, T., Fu, X., Guo, L., Gu, S., Tang, L., Hou, J., & Li, Y. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27926 · Cited by 3
Health and economic impact of hepatitis B vaccination in the national immunization program in Belarus, Georgia, Kyrgyzstan, Republic of Moldova, Turkmenistan and Uzbekistan—a modelling study
Sadeghimehr, M., Mosina, L., Sim, S. Y., & Datta, S. S. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1567033 · Cited by 2
Analysis of the positive results and influencing factors of hepatitis B antibody in hospitalized neonates with AgHBs positive mothers
Min, Y. X., Gao, Y., Liu, C. T., Lu, X., & Chen, X. C. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1042435 · Cited by 2
Immune response and associated factors to Hepatitis B vaccination among children under five attending care at mulago hospital
Kimera, A., Rujumba, J., Ndikuno, C. K., Ndeezi, G., Mukiza, N., Basenero, A., Piloya, T., Bakeera‐Kitaka, S., Nabulya, R., Nalumansi, A. M., et al. (2025) · BMC Pediatrics · doi:10.1186/s12887-024-05366-x · Cited by 2
The Question of Protection: Hepatitis B Vaccine and Waning Antibody Levels
Grayer, D., & Jhaveri, R. R. (2025) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaf044 · Cited by 2
Complementary Presence of HBV Humoral and T-cell Response Provides Protective Immunity after Neonatal Immunization
Huang, Y.-M., Yang, Y., Wu, T., Li, Z., Xu, H., Huang, A., & Zhao, Y. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00272 · Cited by 2
Inadequate Vaccine Responses in Children With Multiple Sclerosis
Santoro, J. D., Saucier, L. E., Tanna, R., Wiegand, S. E., Pagarkar, D., Tempchin, A. F., Khoshnood, M. M., Ahsan, N., & van Haren, K. P. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.790159 · Cited by 2
Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders
Vakili, M. E., Mashhadi, N., Ataollahi, M. R., Meri, S., Kabelitz, D., & Kalantar, K. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13402 · Cited by 1
Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN)
Román, E., Barrio, J., Cilleruelo, M. L., Torres, R., Almazán, V., Coronel, C., Espín, B., Martínez‐Ojinaga, E., Solís, D. P., Moreno, M. A. G., et al. (2024) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2024.09.008 · Cited by 1
Hepatitis B Vaccine: Time to Rethink Our Correlate of Protection
Habash, N. W., & Absah, I. (2026) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2026.04.004 · Cited by 1
Evaluation of hepatitis B vaccination status and immune response among health care workers in a tertiary care hospital in western India
Mehta, T., & Parul, D. S. (2021) · Vacunas · doi:10.1016/j.vacun.2020.09.004 · Cited by 1
Loss of protective anti‐HBs titers and seroconversion to hepatitis B vaccination in children during chemotherapy for acute lymphoblastic leukemia
Prasanth, V. R., Thankamony, P., Rajeswari, B., Sojamani, G. C., Nair, M., Kusumakumary, P., & Krishna, K. M. J. (2022) · Pediatric Blood & Cancer · doi:10.1002/pbc.30154 · Cited by 1
Does co-administration of vaccines interfere with immune responses? The jury is still out
Mondelli, M. U. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.09.022 · Cited by 1
Good Practices and Initiatives for the Control and Elimination of Hepatitis B in the World: A Scoping Review
Jalal, M. A., Mohammed, L. M., Suraifi, M., Namdari, M., Lami, F., Taher, T. M. J., Anied, A. A., Etemad, K., & Karami, M. (2024) · Cureus · doi:10.7759/cureus.59785 · Cited by 1
Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen
Jan, C.-F. J., Liu, T., Ho, C. H., Chien, Y.-C., Chang, C.-J., Guo, F., & Huang, K. (2019) · Family Practice · doi:10.1093/fampra/cmz039 · Cited by 1
Long-Term Protection and Antibody Levels 35 Years after Primary Immunization Series with Hepatitis B Vaccine and Response to a Booster Dose in Those Persons Who Lost AntibodyPreprint
Bruce, M. G., Bruden, D. J. T., Hurlburt, D. A., Morris, J. M., Bressler, S. S., Thompson, G. G., Lecy, D., Rudolph, K. M., BULKOW, L. R., Hennessy, T., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3980547 · Cited by 1
Management of Acute Hepatitis B Virus Infection
Shiffman, M. L. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00536-8
Gating strategy for plasmablast enumeration after hepatitis B vaccination
Byazrova, M. G., Топтыгина, А. П., Mitina, T. A., & Filatov, A. V. (2021) · Medical Immunology (Russia) · doi:10.15789/1563-0625-gsf-2066
Complementary Presence of HBV-Specific Humoral and T-Cellular Immune Response Provide the Long-Lasting Immune Protection After Neonatal ImmunizationPreprint
Huang, Y., Yang, Y., Wu, T., Li, Z., & Zhao, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-436535/v1
Table of Contents
(2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv738
Evaluation of hepatitis B vaccination status and immune response among health care workers in a tertiary care hospital in western India
Tanmay, K. M., & Parul, D. S. (2021) · Vacunas (English Edition) · doi:10.1016/j.vacune.2020.09.002
Hepatitis B Vaccines
Damme, P. V., & Vorsters, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-77173-7_13
Hepatitis B and Hepatitis D Viruses
Harris, A. M., & Schillie, S. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00213-5
Reply
Habash, N. W., & Abash, I. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.05.031
Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study
Hashem, M., Abdel-Haleem, H., Khairy, M., Nassef, A., Essam, M., & Desouky, E. D. E. (2023) · Microbes and Infectious Diseases /Microbes and Infectious Diseases · doi:10.21608/mid.2023.236668.1617
Comparison of Hepatitis B Surface Antibody Levels After Vaccination With Combined One Dose of Hexavalent Vaccine and Two Doses of Pentavalent Vaccine Versus Three Doses of Pentavalent Vaccine
Soonthornarrak, K., Limrungsikul, A., & Apiwattanakul, N. (2024) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000004449
Hepatitis B Virus Immunity Status and Booster Dose Efficacy in Health Sciences Students: An Interventional Study
Shokouh, S. J. H., Naseh, I., Barati, M., Gholami, M., & Farkhonderay, A. (2024) · Annals of Military and Health Sciences Research · doi:10.5812/amh-153329
Acute hepatitis B infections reported among appropriately vaccinated individuals, Philadelphia: A Role for Booster Doses?
Tan, M., Addish, E., Epstein, S., & Kuncio, D. E. (2025) · Vaccine X · doi:10.1016/j.jvacx.2025.100757
Booster Vaccination Against Invasive Pneumococcal Disease and Hepatitis B in Previously Vaccinated Solid Organ Transplant Recipients Without Seroprotection
Sejerøe-Olsen, J., Suarez‐Zdunek, M. A., Helbo, T., Hornung, L. B., Jørgensen, C. S., Rossing, K., Perch, M., Rasmussen, A., Hamm, S. R., & Nielsen, S. D. (2025) · Vaccines · doi:10.3390/vaccines13121253
Additional file 1 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.25422342
Additional file 3 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.26693907
Additional file 4 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.26693910
Additional file 1 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700068
Additional file 3 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700074
Additional file 2 of Immune response to hepatitis B vaccine among children under 5 years in Africa: a meta-analysis
Olakunde, B. O., Ifeorah, I. M., Adeyinka, D. A., Olakunde, O. A., Ogundipe, T., Olawepo, J. O., & Ezeanolue, E. E. (2024) · Figshare · doi:10.6084/m9.figshare.26700071
Additional file 2 of Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017
Sperle, I., Lassen, S. G., Schlaud, M., Dörre, A., Dudareva, S., Poethko‐Müller, C., & Harder, T. (2024) · Figshare · doi:10.6084/m9.figshare.25422405
Letter: Double‐Dose Hepatitis B Vaccination in IBD —A Step Forward in Protecting Immunosuppressed Patients. Authors' Reply
Singh, A. K., Birda, C. L., & Dutta, U. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70603
Baseline Hepatitis B Immunity and Vaccination Booster Response Among Medical Residents: A Longitudinal Study in a Spanish Tertiary Hospital
Salguero-Cano, V., Martínez, S. M., González-Alcaide, M., Valero-Ubierna, C., Martínez‐Ruiz, V., Rivera‐Izquierdo, M., & de Alba, I. G.-F. (2026) · Vaccines · doi:10.3390/vaccines14030280
Prevalence of hepatitis B surface antibodies and hepatitis B exposure in Belgium: results from a nationwide population-based serosurvey
d’Almeida, A. F., Ho, E., Beutels, P., Maertens, K., Hens, N., Damme, P. V., Theeten, H., & Vanwolleghem, T. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13266-x
Serological evidence of hepatitis B virus exposure and vaccination coverage trends in health sciences students in Albania
Jaho, J., Balilaj, L., Bulla, A., Capraro, Y., Lamfu, L., & Baiocchi, L. (2026) · World Journal of Virology · doi:10.5501/wjv.v15.i2.118992 · Cited by 1
Long-term protection following a primary series of hepatitis B vaccine in Alaska Native children and adults
Steinberg, J., Blake, I., Stevenson, T. J., Wheelock, H., Bruden, D. J. T., Townshend‐Bulson, L., Klejka, J. A., Peterson, M., Cartwright, E. J., Drobeniuc, J., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000978 · Cited by 1
Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations
Roldan, G. A., Fletcher, J., Davie, T., Leventhal, T. M., Lake, J. R., & Udompap, P. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.3831
Hepatitis B virus serological profiles, susceptibility and associated factors among adolescents in a conflict-affected district of Cameroon: a community-based cross-sectional studyPreprint
Yunika, L. K., Tanue, E. A., Ukah, C. E., Ngekeng, S., Afeseh, E., (22470271), S. Z. D., & Ekane, E. G. H. (2026) · Research Square · doi:10.21203/rs.3.rs-11078626/v1

Authors: Simons, B. C., Spradling, P. R., Bruden, D. J. T., Zanis, C., Case, S., Choromanski, T. L., Apodaca, M., Brogdon, H. D., Dwyer, G., Snowball, M., Negus, S., Bruce, M. G., Morishima, C., Knall, C., & McMahon, B. J.
Affiliations: Centers for Disease Control and Prevention (US)
Alaska Native Tribal Health Consortium (US)
University of Washington (US)
University of Alaska Anchorage (US)
Corresponding author: Simons, Brenna C.
ORCID: Simons, Brenna C.
Spradling, Philip R.
Bruden, Dana J. T.
Case, Samantha
Dwyer, Gaelen
Bruce, Michael G.
Morishima, Chihiro
McMahon, Brian J.
Venue: Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2016-04-07
Volume: 214
Issue: 2
Pages: 273-280
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiw142
PMC: PMC4918827
OpenAlex: W2359724621
Cited by: 101
References: 50
Citations by year: 2026: 10 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 16 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 1
FWCI: 6.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Infectious Diseases (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: CDC (U01 PS001097)
National Institute of General Medical Sciences
National Institutes of Health
NIH (P20GM103395, U261IHS0046)
Topics: Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
Keywords: hepatitis B vaccine, hepatitis B virus, cell-mediated immunity, hepatitis B surface antigen, HBV core antigen, NKT cells, cytokine production, miR-155, plasma-derived vaccine
MeSH terms: Adult, Cytological Techniques, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Immunity, Cellular, Longitudinal Studies, Male, Middle Aged, T-Lymphocytes, Time Factors, Hepatitis B Vaccines, MicroRNAs, Enzyme-Linked Immunospot Assay

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks