Sexually acquired hepatitis C infection in HIV-uninfected men who have sex with men using preexposure prophylaxis against HIV.
Abstract
Sexually acquired hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-uninfected men who have sex with men (MSM) have been rare. With the introduction of preexposure prophylaxis (PrEP) against HIV, we hypothesized that these infections would increase. Between 2013 and 2018, we diagnosed 15 likely sexually acquired HCV infections among 14 MSM using PrEP. Most (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring. Half reported increasing sex partners and drug use after starting PrEP; 5 reported injection of methamphetamine. Interventions are needed to prevent sexually acquired HCV infections by MSM using PrEP. Centers for Disease Control and Prevention guidelines for monitoring during PrEP should include regular ALT and HCV testing.
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HCV is not efficiently transmitted through sex.
“HCV is not efficiently transmitted through sex (1333–1335).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1335]
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- Authors
- Price, J. C., McKinney, J. E., Crouch, P.-C., Dillon, S. M., Radix, A., Stivala, A., Carollo, J. R., & Fierer, D. S.
- Affiliations
- University of California, San Francisco (US)
- San Francisco AIDS Foundation, California
- NYU Langone Health (US)
- Callen-Lorde Community Health Center, New York
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Fierer, Daniel S
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-11-20
- Volume
- 219
- Issue
- 9
- Pages
- 1373-1376
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2900591049
- Cited by
- 29
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 9
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American College of Gastroenterology
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- hepatitis C virus, sexually transmitted infections, men who have sex with men, HIV pre-exposure prophylaxis, asymptomatic HCV infection, HCV screening, methamphetamine use, drug use, sexual partners, HCV prevention
- MeSH terms
- Sexual and Gender Minorities, Adult, Genotype, Hepatitis C, Humans, Male, Sexual Behavior, Sexually Transmitted Diseases, Viral, HIV Infections, Hepacivirus, HIV Seronegativity, Pre-Exposure Prophylaxis
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