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Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity
Abstract
Long term B lineage chimeras are used here to study the origin of plasma cells in the mouse. Chimeric mice are constructed by reconstituting lethally irradiated mice with peritoneal cells (PerC) and bone marrow cells from congenic pairs of mice differing in Igh-C allotype. All conventional B cells in these mice express the allotype of the bone marrow donor and nearly all Ly-1 B lineage cells express the allotype of the PerC donor. FACS analysis and immunohistology of these mice shows that virtually all (sig+) B cells in peripheral lymphoid organs are derived from the bone marrow donor. However, despite this overwhelming number of bone marrow-derived B cells in these animals, immunohistological staining of lymphoid organs and gut shows that nearly half of the IgM, IgG, and IgA plasma cells derive from the PerC donor. These data demonstrate that the peritoneal cavity contains a major reservoir of self-replenishing cells that play a significant role in the mucosal immune response. The possibility that these are B cells that belong to the Ly-1 B lineage is discussed.
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Citations
Cited by
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Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307317101 · Cited by 721
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Ramsay, A. J., Husband, A. J., Ramshaw, L. A., Bao, S., Matthaei, K. I., Koehler, G., & Kopf, M. (1994) · Science · doi:10.1126/science.8160012 · Cited by 454
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Koch, M. A., Reiner, G. L., Lugo, K. A., Kreuk, L. S. M., Stanbery, A. G., Ansaldo, E., Seher, T. D., Ludington, W. B., & Barton, G. M. (2016) · Cell · doi:10.1016/j.cell.2016.04.055 · Cited by 315
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Role of B-1a cells in autoimmunity
Duan, B., & Morel, L. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.10.007 · Cited by 256
IgA production without μ or δ chain expression in developing B cells
Macpherson, A. J. S., Lamarre, A., McCoy, K., Harriman, G. R., Odermatt, B., Dougan, G., Hengartner, H., & Zinkernagel, R. M. (2001) · Nature Immunology · doi:10.1038/89775 · Cited by 223
Metadata
- Authors
- Kroese, F. G. M., Butcher, E. C., Stall, A. M., Lalor, P. A., Adams, S., & Herzenberg, L. A.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 1
- Issue
- 1
- Pages
- 75-84
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2108569073
- Cited by
- 344
- References
- 0
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
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