The role of interleukin-6 in mucosal IgA antibody responses in vivo
Abstract
In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo in the development of local IgA antibody responses and illustrate the effectiveness of vector-directed cytokine gene therapy.
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IL-6 transgenic mice show severe plasmacytosis with hypergammaglobulinemia, while IL-6-deficient mice are defective in immunoglobulin production.
“IL-6 transgenic mice show severe plasmacytosis with hypergammaglobulinemia (147), while IL-6-deficient mice are defective in immunoglobulin production (148, 149).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [149]
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- Authors
- Ramsay, A. J., Husband, A. J., Ramshaw, L. A., Bao, S., Matthaei, K. I., Koehler, G., & Kopf, M.
- Affiliations
- Australian National University (AU)
- The University of Sydney (AU)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Max Planck Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany.
- Venue
- Science
- Published
- 1994-04-22
- Volume
- 264
- Issue
- 5158
- Pages
- 561-563
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091064926
- Cited by
- 454
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 12 · 2015: 7 · 2014: 16 · 2013: 5 · 2012: 11
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- interleukin-6, immunoglobulin A, mucosal antibody response, IL-6 knockout mice, IgA-producing cells, ovalbumin challenge, vaccinia virus challenge, recombinant vaccinia virus, cytokine gene therapy, intranasal infection
- MeSH terms
- Animals, Immunoglobulin A, Immunoglobulin G, Intestinal Mucosa, Lung, Lymph Nodes, Mesentery, Mucous Membrane, Mutation, Ovalbumin, Plasma Cells, Transfection, Vaccinia, Vaccinia virus, Interleukin-6, Mice
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