The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
Abstract
HLA-G plays an essential role in feto-maternal tolerance by inhibiting lysis by maternal NK cells. The factors that allow tissue-specific activation of HLA-G gene expression in trophoblasts remain to be characterized. We investigated the potential effect of IL-10, a cytokine which is secreted in placenta, on HLA-G gene transcription in trophoblasts. Using Northern blot, RNase protection assay and RT-PCR analysis, we demonstrated that IL-10 enhances steady-state levels of HLA-G transcription in cultured trophoblast cells. We further tested the effect of IL-10 on HLA-G gene transcription and protein expression in peripheral blood monocytes, showing that IL-10 can up-regulate HLA-G cell surface expression in this cell type. This effect of IL-10 is selective, since classical MHC class I products and MHC class II are down-regulated in monocytes following IL-10 treatment. Induction of HLA-G expression by IL-10 on monocytes may thus play a role in down-regulation of the immune response. We propose that IL-10 secretion by trophoblasts during pregnancy may also influence the HLA class I expression pattern at the feto-maternal barrier, thus protecting the fetus from rejection. This should be taken into consideration in the design of treatment for pathologies of pregnancy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
A Class I Antigen, HLA-G, Expressed in Human Trophoblasts
Kovats, S., Main, E. K., Librach, C., Stubblebine, M., Fisher, S. J., & DeMars, R. (1990) · Science · doi:10.1126/science.2326636 · Cited by 1,407
D'Andrea, A., Aste-Amezaga, M., Valiante, N. M., Ma, X., Kubin, M., & Trinchieri, G. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.3.1041 · Cited by 1,385
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Th 1-type immunity is incompatible with successful pregnancy
Raghupathy, R. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01127-4 · Cited by 1,002
Colonna, M., Navarro, F., Bellón, T., Llano, M., García, P., Samaridis, J., Angman, L., Cella, M., & López-Botet, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.11.1809 · Cited by 950
Del Prete, G., De Carli, M., Almerigogna, F., Giudizi, M. G., Biagiotti, R., & Romagnani, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.2.353 · Cited by 927
Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., & Shevach, E. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1224 · Cited by 829
Rouas-Freiss, N., Gonçalves, R. M.-B., Menier, C., Dausset, J., & Carosella, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11520 · Cited by 701
Self-citation
Cited by
Selmani, Z., Naji, A., Zidi, I., Favier, B., Gaiffe, E., Obert, L., Borg, C., Saas, P., Tiberghien, P., Rouas-Freiss, N., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0554 · Cited by 1,081
Self-citationCarosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
Self-citationImmune modulation by mesenchymal stem cells
Rasmusson, I. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.019 · Cited by 374
HLA-G in human reproduction: aspects of genetics, function and pregnancy complications
Hviid, T. V. F. (2006) · Human Reproduction Update · doi:10.1093/humupd/dmi048 · Cited by 332
Riteau, B., Rouas-Freiss, N., Menier, C., Paul, P., Dausset, J., & Carosella, E. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5018 · Cited by 324
Self-citation
Metadata
- Authors
- Moreau, P., Adrian-Cabestre, F., Menier, C., Guiard, V., Gourand, L., Dausset, J., Carosella, E. D., & Paul, P.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-05
- Volume
- 11
- Issue
- 5
- Pages
- 803-811
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2102151740
- Cited by
- 411
- References
- 51
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes. https://app.cochat.ai/papers/10.1093/intimm/11.5.803
- The paper
- Moreau, P., Adrian-Cabestre, F., Menier, C., Guiard, V., Gourand, L., Dausset, J., Carosella, E. D., & Paul, P. (1999). IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes. International Immunology. https://doi.org/10.1093/intimm/11.5.803
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
