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A Class I Antigen, HLA-G, Expressed in Human Trophoblasts
Abstract
The α chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.
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Cited by
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Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
Paul, P., Rouas-Freiss, N., Khalil-Daher, I., Moreau, P., Riteau, B., Le Gal, F. A., Avril, M. F., Dausset, J., Guillet, J. G., & Carosella, E. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4510 · Cited by 432
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J. (2008) · Blood · doi:10.1182/blood-2007-12-127662 · Cited by 348
Tsang, J. C. H., Vong, J. S. L., Ji, L., Poon, L. C. Y., Jiang, P., Lui, K. O., Ni, Y.-B., To, K. F., Cheng, Y. K. Y., Chiu, R. W. K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710470114 · Cited by 328
Metadata
- Authors
- Kovats, S., Main, E. K., Librach, C., Stubblebine, M., Fisher, S. J., & DeMars, R.
- Venue
- Science
- Published
- 1990-04-13
- Volume
- 248
- Issue
- 4952
- Pages
- 220-223
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986672594
- Cited by
- 1,407
- References
- 0
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kovats, S., Main, E. K., Librach, C., Stubblebine, M., Fisher, S. J., & DeMars, R. (1990). A Class I Antigen, HLA-G, Expressed in Human Trophoblasts. Science. https://doi.org/10.1126/science.2326636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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