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Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
Abstract
CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-gamma mRNA. In contrast, animals restored with the reciprocal CD45RBlow subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RBlow population with the CD45RBhigh population prevented the wasting disease and colitis. These data indicate that important regulatory interactions occur between the CD45RBhigh and CD45RBlowCD4+ T cell subsets and that disruption of this mechanism has fatal consequences.
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“Early seminal studies identified a definitive link between Th1 cells and colitis (47, 71)”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [47]
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Metadata
- Authors
- Powrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L.
- Corresponding author
- Powrie, Flona
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 5
- Issue
- 11
- Pages
- 1461-1471
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2002061924
- Cited by
- 1,078
- References
- 0
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 10 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 22 · 2018: 28 · 2017: 34 · 2016: 34 · 2015: 49 · 2014: 42 · 2013: 44 · 2012: 45
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- CD4+ T cells, CD45RB, T cell subsets, chronic intestinal inflammation, colitis, wasting disease, interferon-gamma, SCID mice, immunodeficient mice
- MeSH terms
- Animals, Colitis, Female, Flow Cytometry, Interferon-gamma, Mice, Inbred BALB C, RNA, Messenger, Inflammatory Bowel Diseases, Weight Loss, CD4-Positive T-Lymphocytes, Polymerase Chain Reaction, Mice, SCID, Leukocyte Common Antigens, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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