Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

Involvement of 4-1BB (CD137)−4-1BBligand interaction in the modulation of CD4+ T cell-mediated inflammatory colitis

Maerten, P., Kwon, B. S., Shen, C., Hertogh, G. D., Cadot, P., Bullens, D. M. A., Overbergh, L., Mathieu, C., Assche, G. V., Geboes, K. J., et al. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02991.x · Cited by 29

Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I)

Chandran, P., Satthaporn, S., Robins, A., & Eremin, O. (2003) · The Surgeon · doi:10.1016/s1479-666x(03)80118-x · Cited by 29

IgA production in MHC class II-deficient mice is primarily a function of B-1a cells

Snider, D. P., Liang, H., Switzer, I., & Underdown, B. J. (1999) · International Immunology · doi:10.1093/intimm/11.2.191 · Cited by 29

A Novel Costimulation Pathway Via the 4C8 Antigen for the Induction of CD4+ Regulatory T Cells

Masuyama, J., Kaga, S., Kano, S., & Minota, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3710 · Cited by 29

Insights into the Pathogenesis of Inflammatory Bowel Diseases Provided by New Rodent Models of Spontaneous Colitis

Sartor, R. B. (1995) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199503000-00007 · Cited by 29

Systemic, but Not Intestinal, IL-7 Is Essential for the Persistence of Chronic Colitis

Tomita, T., Kanai∥, T., Nemoto, Y., Totsuka, T., Okamoto, R., Tsuchiya, K., Sakamoto, N., & Watanabe, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.383 · Cited by 28

A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice

Schmitt, E. G., Toth, K. A., Risma, S. I., Kolicheski, A., Saucier, N., Berríos, R. J. F., Greenberg, Z. J., Leiding, J. W., Bleesing, J., Thatayatikom, A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.162695 · Cited by 28

Soluble TNF‐α but not transmembrane TNF‐α sensitizes T cells for enhanced activation‐induced cell death

Müller, S., Rihs, S., Schneider, J., Paredes, B. E., Seibold, I., Brunner, T., & Mueller, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939554 · Cited by 28

Effects of Dietary Plant Sterols and Stanol Esters with Low- and High-Fat Diets in Chronic and Acute Models for Experimental Colitis

Velde, A. A. T., Brüll, F., Heinsbroek, S. E. M., Meijer, S. L., Lütjohann, D., Vreugdenhil, A. C. E., & Plat, J. (2015) · Nutrients · doi:10.3390/nu7105412 · Cited by 28

Environment as a Critical Factor for the Pathogenesis and Outcome of Gastrointestinal Disease: Experimental and Human Inflammatory Bowel Disease and Helicobacter-Induced Gastritis

Bleich, A., & Mähler, M. (2005) · Pathobiology · doi:10.1159/000091327 · Cited by 28

TCR-Mediated Involvement of CD4+ Transgenic T Cells in Spontaneous Inflammatory Bowel Disease in Lymphopenic Mice

Koh, W., Chan, E., Scott, K. A., McCaughan, G. W., France, M., & Groth, B. F. D. S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7208 · Cited by 28

ILC3s sense gut microbiota through STING to initiate immune tolerance

Zhou, W., Zhou, J., Ahmed, A., Kim, M. J., Guo, C., & Sonnenberg, G. F. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.016 · Cited by 27

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T‐cell‐driven inflammatory responses in vivo

Newman, T., Liverani, E., Ivanova, E., Russo, G. L., Carpino, N., Ganea, D., Safadi, F. F., Kunapuli, S. P., & Tsygankov, A. Y. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.60 · Cited by 27

Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen

Tsuda, M., Hosono, A., Yanagibashi, T., Fujioka, M., Hachimura, S., Itoh, K., Hirayama, K., Takahashi, K., & Kaminogawa, S. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.05.007 · Cited by 27

Roquin—a multifunctional regulator of immune homeostasis

Schaefer, J. S., & Klein, J. R. (2015) · Genes and Immunity · doi:10.1038/gene.2015.58 · Cited by 27

Influences of non-IgE-mediated cow's milk protein allergy-associated gut microbial dysbiosis on regulatory T cell-mediated intestinal immune tolerance and homeostasis

Wang, J., Zheng, S., Yang, X., Huazeng, B., & Cheng, Q. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105020 · Cited by 27

Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity

Hanna, J., Beke, F., O’Brien, L. M., Kapeni, C., Chen, H., Carbonaro, V., Kim, A. B., Kishore, K., Adolph, T. E., Skjoedt, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31722-5 · Cited by 28

The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis

Kokkinou, E., Soini, T., Pandey, R. V., Acker, A. V., Theorell, J., Czarnewski, P., Kvedaraite, E., Vandamme, N., Lourda, M., Sorini, C., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101038 · Cited by 27

Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Q a‐1‐restricted CD 8+ regulatory cells

Yao, Y., Han, W., Liang, J., Ji, J., Wang, J., Cantor, H., & Lu, L. (2012) · European Journal of Immunology · doi:10.1002/eji.201242758 · Cited by 27

Effects of T cell-induced colonic inflammation on epithelial barrier function†

Suenaert, P., Maerten, P., Assche, G. V., Driessche, W. V., Geboes, K. J., Bulteel, V., Simaels, J., Augustijns, P., Ceuppens, J. L., Rutgeerts, P., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21211 · Cited by 27

Recent thymic origin, differentiation, and turnover of regulatory T cells

Mabarrack, N. H. E., Turner, N. L., & Mayrhofer, G. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0308201 · Cited by 27

Restoration of Foxp3+ Regulatory T-cell Subsets and Foxp3− Type 1 Regulatory-like T Cells in Inflammatory Bowel Diseases During Anti-tumor Necrosis Factor Therapy

Li, Z., Vermeire, S., Bullens, D. M. A., Ferrante, M., Steen, K. V., Noman, M., Rutgeerts, P. J., Ceuppens, J. L., & Assche, G. V. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000509 · Cited by 27

Guarding the immune system: Suppression of autoimmunity by CD4+CD25+ immunoregulatory T cells

Zwar, T. D., van Driel, I. R., & Gleeson, P. A. (2006) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2006.01471.x · Cited by 27

Regulation of autoimmune diabetes by non‐islet‐specific T cells — a role for the glucocorticoid‐induced TNF receptor

Suri, A., Shimizu, J., Katz, J. D., Sakaguchi, S., Unanue, E. R., & Kanagawa, O. (2004) · European Journal of Immunology · doi:10.1002/eji.200324599 · Cited by 27

HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone

Mellado, M., Llorente, M., Rodríguez-Frade, J. M., Lucas, P., Martínez-A, C., & del Real, G. (1998) · Vaccine · doi:10.1016/s0264-410x(98)80106-0 · Cited by 26

A Structured Approach to Optimizing Animal Model Selection for Human Translation: The Animal Model Quality Assessment

Storey, J., Gobbetti, T., Olzinski, A. R., & Berridge, B. R. (2021) · ILAR Journal · doi:10.1093/ilar/ilac004 · Cited by 27

Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4+T Cell–Mediated Colitis in Mice

Liao, G., Detre, C., Berger, S. B., Engel, P., Malefyt, R. D. W., Herzog, R. W., Bhan, A. K., & Terhorst, C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.031 · Cited by 27

CD4 + regulatory cells as a potential immunotherapy

Fehervari, Z. T., & Sakaguchi, S. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1695 · Cited by 26

CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice

Veltkamp, C., Ruhwald, R., Giesem, T., Autschbach, F., Kaden, I., Veltkamp, R. C., Sartor, R. B., & Stremmel, W. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200606000-00002 · Cited by 26

The Role of Neuropeptides in Mouse Models of Colitis

Padua, D. M., Vu, J. P., Germano, P. M., & Pisegna, J. R. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0688-1 · Cited by 26

Experimental Mouse Models of T Cell-Dependent Inflammatory Bowel Disease

Song-Zhao, G. X., & Maloy, K. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1212-4_18 · Cited by 26

Differential localization of colitogenic Th1 and Th2 cells monospecific to a microflora-associated antigen in mice

Yoshida, M., Shirai, Y., Watanabe, T., Yamori, M., Iwakura, Y., Chiba, T., Kita, T., & Wakatsuki, Y. (2002) · Gastroenterology · doi:10.1053/gast.2002.37049 · Cited by 26

Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4+ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients

Thomas, J., & Rouse, B. T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.3965 · Cited by 26

T cell Tolerance in Early Life

Yang, L., Jin, R., Lü, D., & Ge, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576261 · Cited by 28

IL10 Secretion Endows Intestinal Human iNKT Cells with Regulatory Functions Towards Pathogenic T Lymphocytes

Burrello, C., Strati, F., Lattanzi, G., Díaz‐Basabe, A., Mileti, E., Giuffrè, M. R., Lopez, G., Cribiù, F. M., Trombetta, E., Kallikourdis, M., et al. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac049 · Cited by 25

Small Intestine Inflammation in Roquin-Mutant and Roquin-Deficient Mice

Schaefer, J. S., Montufar‐Solis, D., Nakra, N., Vigneswaran, N., & Klein, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056436 · Cited by 25

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Pei, R., Martin, D., Valdez, J. C., Liu, J., Kerby, R. L., Rey, F. E., Smyth, J. A., Liu, Z., & Bolling, B. W. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800985 · Cited by 25

Role of regulatory T cells in gastrointestinal inflammatory disease

van Driel, I. R., & Ang, D. K. Y. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05278.x · Cited by 25

CD4 T cells monospecific to ovalbumin produced by Escherichia coli can induce colitis upon transfer to BALB/c and SCID mice

Yoshida, M., Watanabe, T., Usui, T., Matsunaga, Y., Shirai, Y., Yamori, M., Itoh, T., Habu, S., Chiba, T., Kita, T., et al. (2001) · International Immunology · doi:10.1093/intimm/13.12.1561 · Cited by 25

Trafficking of regulatory T cells in the intestinal immune system

Pabst, O. (2012) · International Immunology · doi:10.1093/intimm/dxs113 · Cited by 25

Tipping the balance: inhibitory checkpoints in intestinal homeostasis

Joosse, M. E., Nederlof, I., Walker, L. S. K., & Samsom, J. N. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0113-5 · Cited by 24

Intestinal Regulatory T Cells

Figliuolo, V. R., Jamwal, D. R., & Kiela, P. R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6407-9_9 · Cited by 28

Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles

Golusda, L., Kühl, A. A., Lehmann, M., Dahlke, K., Mueller, S. G., Boehm‐Sturm, P., Saatz, J., Traub, H., Schnorr, J., Freise, C., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.862212 · Cited by 24

Perturbation of the CD4 T Cell Compartment and Expansion of Regulatory T Cells in Autoimmune-Prone Lyn-Deficient Mice

Tsantikos, E., Quilici, C., Harder, K. W., Wang, B., Zhu, H., Anderson, G. P., Tarlinton, D. M., & Hibbs, M. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804346 · Cited by 25

The Resurrection of T Cell-Mediated Suppression

Shevach, E. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100364 · Cited by 24

Anti‐CD4‐mediated selection of Treg in vitro – in vitro suppression does not predict in vivo capacity to prevent graft rejection

Oliveira, V. G., Sawitzki, B., Chapman, S. J., Appelt, C., Gebuhr, I., Więckiewicz, J., Long, E., & Wood, K. J. (2008) · European Journal of Immunology · doi:10.1002/eji.200737562 · Cited by 24

Mesenteric lymph nodes contribute to proinflammatory Th17‐cell generation during inflammation of the small intestine in mice

Kawabe, T., Suzuki, N., Yamaki, S., Sun, S., Asao, A., Okuyama, Y., So, T., Iwakura, Y., & Ishii, N. (2016) · European Journal of Immunology · doi:10.1002/eji.201545907 · Cited by 25

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity

Chruscinski, A. J., Sadozai, H., Rojas-Luengas, V., Bartczak, A. M., Khattar, R., Selzner, N., & Levy, G. A. (2015) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10209 · Cited by 24

Making sense of the cause of Crohn’s – a new look at an old disease

Segal, A. W. (2016) · F1000Research · doi:10.12688/f1000research.9699.2 · Cited by 25

A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses.

Fehervari, Z. T., & Sakaguchi, S. (2004) · Arthritis Research · doi:10.1186/ar1037 · Cited by 24

Therapeutic targeting of α4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?

Engelhardt, B., & Briskin, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200535195 · Cited by 24

Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084619 · Cited by 24

Use of CFSE to MonitorEx VivoRegulatory T-cell Suppression of CD4+and CD8+T-cell Proliferation within Unseparated Mononuclear Cells from Malignant and Non-Malignant Human Lymph Node Biopsies

Hilchey, S. P., & Bernstein, S. H. (2007) · Immunological Investigations · doi:10.1080/08820130701674463 · Cited by 23

Mechanisms regulating the development and function of natural regulatory T cells

Gupta, S., Shang, W., & Sun, Z. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0015-4 · Cited by 23

Initiation and Resolution of Mucosal Inflammation

Sherman, M. A., & Kalman, D. (2004) · Immunologic Research · doi:10.1385/ir:29:1-3:241 · Cited by 23

Autologous stem cell transplantation for paediatric‐onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T‐ and B‐cell repertoires, and evidence for reversion from the CD45RO+ to RA+ phenotype

Wedderburn, L. R., Jeffery, R. C., White, H. N., Patel, A., Varsani, H., Linch, D. C., Murray, K. J., & Woo, P. M. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.11.1299 · Cited by 23

Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology

Okamoto, Y., & Shikano, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1179456 · Cited by 28

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Lee, V., Rodriguez, D. M., Ganci, N. K., Zeng, S., Ai, J., Chao, J. L., Walker, M. T., Miller, C. H., Klawon, D. E. J., Schoenbach, M. H., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01425-0 · Cited by 23

Overview of Mouse Models of Inflammatory Bowel Disease and Their Use in Drug Discovery

Maxwell, J. R., & Viney, J. L. (2009) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0557s47 · Cited by 22

The Development of Colitogenic CD4+ T Cells Is Regulated by IL-7 in Collaboration with NK Cell Function in a Murine Model of Colitis

Yamaji, O., Nagaishi, T., Totsuka, T., Onizawa, M., Suzuki, M., Tsuge, N., Hasegawa, A., Okamoto, R., Tsuchiya, K., Nakamura, T., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100371 · Cited by 22

Comparative Effects of Probiotics, Prebiotics, and Synbiotics on Growth Factors in the Large Bowel in a Rat Model of Formula‐induced Bowel Inflammation

Fordjour, L., D’Souza, A., Cai, C. L., Ahmad, A. H., Valencia, G., Kumar, D., Aranda, J. V., & Beharry, K. D. A. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181df5ff2 · Cited by 22

The Contribution of Thymic Stromal Abnormalities to Autoimmune Disease

Fletcher, A. L., Calder, A. E., Hince, M. N., Boyd, R. L., & Chidgey, A. P. (2011) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v31.i3.10 · Cited by 22

Effect of endogen‐exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid–induced colitis

Taşdemir, S., Parlakpınar, H., Vardı, N., Kaya, E., & Acet, A. (2011) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2011.01016.x · Cited by 23

Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

Schulte, L.-A., Hohwieler, M., Müller, M., & Klaus, J. (2019) · Stem Cells International · doi:10.1155/2019/8010645 · Cited by 22

Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis

Nemoto, Y., Kanai∥, T., Tohda, S., Totsuka, T., Okamoto, R., Tsuchiya, K., Nakamura, T., Sakamoto, N., Fukuda, T., Miura, O., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20531 · Cited by 22

Control of peripheral T-lymphocyte tolerance in neonates and adults.

Arnold, B., Schüler, T., & Hämmerling, G. (2005) · Trends in immunology · doi:10.1016/j.it.2005.06.002 · Cited by 23

CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease

Zelman-Toister, E., Bakos, E., Cohen, S., Zigmond, E., Shezen, E., Grabovsky, V., Sagiv, A., Hart, G., Kaushansky, N., Ben-Nun, A., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000621 · Cited by 22

CD4+ T regulatory cells from the colonic lamina propria of normal mice inhibit proliferation of enterobacteria-reactive, disease-inducing Th1-cells from scid mice with colitis

Gad, M., Brimnes, J., & Claësson, M. H. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02049.x · Cited by 22

Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease

Reimann, J., Rudolphi, A., & Claësson, M. H. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00198241 · Cited by 22

Control of immune pathology by IL-10-secreting regulatory T cells

Fowler, S., & Powrie, F. M. (1999) · Springer Seminars in Immunopathology · doi:10.1007/bf00812258 · Cited by 22

Regulatory T Cells in Experimental Colitis

Gad, M. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-27702-1_9 · Cited by 22

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells

Lozano‐Ruiz, B., Tzoumpa, A., Martínez‐Cardona, C., Moreno, D., Aransay, A. M., Cortázar, A. R., Picó, J., Peiró, G., Lozano, J., Zapater, P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042230 · Cited by 20

Multifactorial patterns of gene expression in colonic epithelial cells predict disease phenotypes in experimental colitis

Frantz, A. L., Bruno, M. E. C., Rogier, E. W., Tuna, H., Cohen, D. A., Bondada, S., Chelvarajan, L., Brandon, J. A., Jennings, D. C., & Kaetzel, C. S. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22923 · Cited by 21

CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease

Cosorich, I., McGuire, H. M., Warren, J. A., Danta, M., & King, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02899 · Cited by 22

Lamin A/C deficiency in CD4 + T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease

Toribio‐Fernández, R., Herrero‐Fernández, B., Zorita, V., López, J. A., Vázquez, J., Criado, G., Pablos, J. L., Collas, P., Sánchez‐Madrid, F., Andrés, V., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5332 · Cited by 21

Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis

Furze, R. C., Culley, F. J., & Selkirk, M. E. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.08.013 · Cited by 21

Signaling triggered by glucocorticoid-induced tumor necrosis factor receptor family-related gene: Regulation at the interface between regulatory T cells and immune effector cells

Edward, M. (2006) · Frontiers in bioscience · doi:10.2741/1895 · Cited by 21

Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

Bündgen, G., Ulges, A., Pietruschka, J., Truong-Andrievici, N., Klein, M., Romaniuk, K., Schmitt, F., Hagen, M., Seebass, J. G., Zezlina, L., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.07.007 · Cited by 23

Extrathymic Generation of Regulatory T Cells—Chances and Challenges for Prevention of Autoimmune Disease

Daniel, C., & von Boehmer, H. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387827-4.00005-x · Cited by 21

Signaling Lymphocyte Activation Molecule Regulates Development of Colitis in Mice

van Driel, B., Liao, G., Ros, X. R., O’Keeffe, M. S., Wang, G., Faubion, W. A., Berger, S. B., Magelky, E. M., Manocha, M., Azcutia, V., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.042 · Cited by 20

Glucocorticoids and IL‐10, but not 6‐MP, 5‐ASA or sulfasalazine block endothelial expression of MAdCAM‐1: implications for inflammatory bowel disease therapy

Oshima, T., Pavlick, K. P., Grisham, M. B., Jordan, P., Manas, K. J., Joh, T., Itoh, M., & Alexander, J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01048.x · Cited by 20

Regulatory T Cells: Potential Target in Anticancer Immunotherapy

Juang, C., Hung, C., Yeh, J.-Y., Horng, H., Twu, N., Cheng, M., Wen, K.-C., Yuan, C., Chao, K.-C., Wu, T. ‐., et al. (2007) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(08)60023-6 · Cited by 19

Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses

Kawabe, T., Ciucci, T., Kim, K. S., Tayama, S., Kawajiri, A., Suzuki, T., Tanaka, R., Ishii, N., Jankovic, D. L., Zhu, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870542 · Cited by 19

Raf Signaling but not the ERK Effector SAP-1 Is Required for Regulatory T Cell Development

Willoughby, J. E., Costello, P. S., Nicolas, R. H., Robinson, N. J., Stamp, G., Powrie, F. M., & Treisman, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6836 · Cited by 19

Mechanisms and Models for Intestinal Fibrosis in IBD

Salvo, C. D., Ray, S., & Pizarro, T. T. (2014) · Digestive Diseases · doi:10.1159/000367822 · Cited by 19

Immunological alterations mediated by adenosine during host-microbial interactions

Drygiannakis, I., Ernst, P. B., Lowe, D. E., & Glomski, I. J. (2011) · Immunologic Research · doi:10.1007/s12026-011-8207-0 · Cited by 19

Is aspirin treatment an appropriate intervention for osteoporosis?

Yamaza, T., Akiyama, K., & Shi, S. (2008) · Future Rheumatology · doi:10.2217/17460816.3.6.499 · Cited by 19

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Summary

Powrie, F. M., & Mason, D. (2013)

CD45RBHIGH CD4+ T-CELLS INDUCE A PATHOGENIC TH1 RESPONSE IN THE COLON WHEN TRANSFERRED TO C-B-17 SCID MICE WHICH IS PREVENTED BY CO-TRANSFER OF THE CD45RBLOW POPULATION

Powrie, F. M., Leach, M. W., & Coffman, R. L. (1994) · Journal of Cellular Biochemistry · Cited by 1