Cited by 1,078T-cell and B-cell ImmunologyInflammatory Bowel DiseasePsoriasis: Treatment and Pathogenesis

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Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

Powrie, Flona, Leach, Michael W., Mauze, Smita, Caddie, Linda Barcomb, Coffman, Robert L.·1993·International Immunology

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Abstract

CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-gamma mRNA. In contrast, animals restored with the reciprocal CD45RBlow subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RBlow population with the CD45RBhigh population prevented the wasting disease and colitis. These data indicate that important regulatory interactions occur between the CD45RBhigh and CD45RBlowCD4+ T cell subsets and that disruption of this mechanism has fatal consequences.

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Authors: Powrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L.
Corresponding author: Powrie, Flona
ORCID: Leach, Michael W.
Coffman, Robert L.
Venue: International Immunology
Publisher: Oxford University Press (OUP)
Published: 1993
Volume: 5
Issue: 11
Pages: 1461-1471
ISSN: 0953-8178 (ISSN-L)
1460-2377
DOI: 10.1093/intimm/5.11.1461
OpenAlex: W2002061924
Cited by: 1,078
References: 0
Citations by year: 2026: 19 · 2025: 21 · 2024: 10 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 22 · 2018: 28 · 2017: 34 · 2016: 34 · 2015: 49 · 2014: 42 · 2013: 44 · 2012: 45
FWCI: 5.53
Type: journal article
Language: en
Open access: closed
Locations: International Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: CD4+ T cells, CD45RB, T cell subsets, chronic intestinal inflammation, colitis, wasting disease, interferon-gamma, SCID mice, immunodeficient mice
MeSH terms: Animals, Colitis, Female, Flow Cytometry, Interferon-gamma, Mice, Inbred BALB C, RNA, Messenger, Inflammatory Bowel Diseases, Weight Loss, CD4-Positive T-Lymphocytes, Polymerase Chain Reaction, Mice, SCID, Leukocyte Common Antigens, Mice

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Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

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