The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components
Abstract
Lipoteichoic acid (LTA) derived from Staphylococcus aureus is reported to be a ligand of Toll-like receptor 2 (TLR2). In this study, we demonstrated that lipoproteins obtained from S. aureus are potent activators of TLR2. A fraction obtained by Triton X-114 phase partitioning activated cells through TLR2. The fraction contained proteins and LTA. The activity was detected in compounds in a mass range of 12-40 kDa. Proteinase K digested the active compounds into lower molecular weight active materials <10 kDa. In contrast, hydrofluoric acid treatment, which decomposes LTA, did not alter the molecular mass of the active compounds. Further, most of the activity was abrogated by lipoprotein lipase digestion. These results suggested that lipoproteins are predominant TLR2 ligands in S. aureus cell wall components.
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A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“TLR4, the most characterized member of the family, in combination with an adapter molecule MD-2 has been shown to recognize LPS, an outer membrane component of gram-negative bacteria (2, 3). TLR9 has been reported to be involved in immune responses to unmethylated CpG DNA ( 4 ), and TLR3 and TLR7/8 sense viral double-…”
BackgroundRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704
Cited by
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
Inflammation and preterm birth
Cappelletti, M., Della Bella, S., Ferrazzi, E., Mavilio, D., & Divanovic, S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0615-272rr · Cited by 293
Toll-like receptors in skin infections and inflammatory diseases
Lai, Y., & Gallo, R. (2008) · Infectious Disorders - Drug Targets · doi:10.2174/1871526510808030144 · Cited by 119
Post-translational processing targets functionally diverse proteins in Mycoplasma hyopneumoniae
Tacchi, J. L., Raymond, B. B. A., Haynes, P. A., Berry, I. J., Widjaja, M., Bogema, D. R., Woolley, L. K., Jenkins, C., Minion, F. C., Padula, M. P., et al. (2016) · Open Biology · doi:10.1098/rsob.150210 · Cited by 62
Nielsen, C., Balachandran, P., Christensen, O., Pugh, N., Tamta, H., Sufka, K., Wu, X., Walsted, A., Schjørring-Thyssen, M., Enevold, C., et al. (2010) · Planta Medica · doi:10.1055/s-0030-1250043 · Cited by 56
Metadata
- Authors
- Hashimoto, M., Tawaratsumida, K., Kariya, H., Aoyama, K., Tamura, T., & Suda, Y.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-22
- Volume
- 18
- Issue
- 2
- Pages
- 355-362
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2139655699
- Cited by
- 169
- References
- 3
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hashimoto, M., Tawaratsumida, K., Kariya, H., Aoyama, K., Tamura, T., & Suda, Y. (2006). Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components. International Immunology. https://doi.org/10.1093/intimm/dxh374
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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