The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation
Open accessAbstract
CD4 T(h) are critical for orchestrating adaptive immune responses. The expression of the transcription factor GATA3 (GATA-binding protein 3) is up-regulated or down-regulated during T(h)2 or T(h)1 cell differentiation, respectively. Furthermore, GATA3 is responsible for induction of T(h)2 differentiation and represses T(h)1 differentiation. In this review, we present an updated view on the molecular mechanisms through which GATA3 regulates T(h)1/T(h)2 differentiation. During T(h)2 cell differentiation, GATA3 directly binds to the T(h)2 cytokine gene locus at several regions and regulates expression. On the other hand, GATA3 inhibits T(h)1 cell differentiation by preventing up-regulation of IL-12 receptor β2 and STAT4 (signal transducer and activator of transcription 4) and neutralization of Runx3 (runt-related transcription factor 3) function through protein-protein interaction. GATA3 may also directly act on the Ifng gene. In summary, GATA3 serves as a transcriptional activator or repressor through direct action on transcriptional machinery and/or affecting chromatin remodeling at many critical loci encoding cytokines, cytokine receptors, signaling molecules as well as transcription factors that are involved in the regulation of T(h)1 and T(h)2 differentiation.
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Cites
Differentiation of Effector CD4 T Cell Populations
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TH2 cell development and function
Walker, J. A., & McKenzie, A. N. J. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.118 · Cited by 632
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Self-citationThe cytokine networks of adaptive immunity in fish
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GATA3: a master of many trades in immune regulation
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Metadata
- Authors
- Yagi, R., Zhu, J., & Paul, W. E.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-01
- Volume
- 23
- Issue
- 7
- Pages
- 415-420
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2136423984
- Cited by
- 250
- References
- 4
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- green
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