The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Dissecting the formation, structure and barrier function of the stratum corneum
Open accessAbstract
The skin is the largest organ of the mammalian body. The outermost layer of mammalian skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that are the end-products of terminal differentiation of epidermal keratinocytes. The SC performs a crucial barrier function of epidermis. Langerhans cells, when activated, extend their dendrites through tight junctions just beneath the SC to capture external antigens. Recently, knowledge of the biology of corneocytes (‘corneobiology’) has progressed rapidly and many key factors that modulate its barrier function have been identified and characterized. In this review article on the SC, we summarize its evolution, formation, structure and function. Cornification is an important step of SC formation at the conversion of living epithelial cells to dead corneocytes, and consists of three major steps: formation of the intracellular keratin network, cornified envelopes and intercellular lipids. After cornification, the SC undergoes chemical reactions to form the mature SC with different functional layers. Finally, the SC is shed off at the surface (‘desquamation’), mediated by a cascade of several proteases. This review will be helpful to understand our expanding knowledge of the biology of the SC, where immunity meets external antigens.
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Cites
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Enhancement strategies for transdermal drug delivery systems: current trends and applications
Ramadon, D., McCrudden, M. T. C., Courtenay, A. J., & Donnelly, R. F. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00909-6 · Cited by 649
Toward a new generation of smart skins
Someya, T., & Amagai, M. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0079-1 · Cited by 474
Self-citationInnate immunity in vertebrates: an overview
Riera Romo, M., Pérez‐Martínez, D., & Castillo Ferrer, C. (2016) · Immunology · doi:10.1111/imm.12597 · Cited by 435
Focus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D′Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 396
Metadata
- Authors
- Matsui, T., & Amagai, M.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-26
- Volume
- 27
- Issue
- 6
- Pages
- 269-280
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2145184711
- Cited by
- 364
- References
- 110
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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