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Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli
Abstract
OBJECTIVES: To evaluate the antimicrobial and synergistic (hypothetically due to the inhibition of efflux pumps) effects of selective serotonin reuptake inhibitors (SSRIs) in Escherichia coli strains overproducing various resistance-nodulation-division (RND) efflux pumps. METHODS: MICs of various SSRIs and of clinically relevant antibiotics in the presence and absence of sertraline were determined for E. coli strains overproducing the RND efflux pumps AcrAB, AcrEF, MdtEF and MexAB. The effect of sertraline on Nile red efflux was evaluated in a real-time efflux assay. Expression of marA and acrB was monitored using quantitative RT-PCR. RESULTS: In MIC assays there was limited synergy of sertraline with tetracycline, oxacillin, linezolid and clarithromycin, depending on the individual pump overexpressed and on whether rich or minimal medium was used. Sertraline, as the most potent SSRI with regard to bacterial growth inhibition, led to rapid dose-dependent Nile red efflux inhibition, and was also found to increase the expression of marA and acrB. CONCLUSIONS: A possible explanation for the discrepancy between the MIC and real-time efflux assays was that sertraline is a weak inducer of marA and acrB, thereby reducing its initial antibacterial and sensitizing effects over time. The results indicate that sertraline may be useful as a model efflux pump inhibitor for in vitro short-term experiments in E. coli, but is unlikely to be clinically useful as a co-drug against Gram-negative bacteria.
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“In addition, the antimicrobial activity of some antidepressants has been confirmed by the synergistic effect of some SSRIs in combination with antibiotics, as well as their effects against some antibiotic-resistant bacteria (Bohnert et al., 2011;Munoz-Bellido et al., 1996, 2000).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Bohnert et al., 2011
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Cites
Culture Medium for Enterobacteria
Neidhardt, F. C., Bloch, P. L., & Smith, D. F. (1974) · Journal of Bacteriology · doi:10.1128/jb.119.3.736-747.1974 · Cited by 2,903
Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903
Has the era of untreatable infections arrived?
Livermore, D. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp255 · Cited by 619
Pagès, J., & Amaral, L. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.12.011 · Cited by 328
Antimicrobial activity of psychotropic drugs
Munoz-Bellido, J. L., Munoz-Criado, S., & Garcı̀a-Rodrı̀guez, J. A. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00154-5 · Cited by 249
Chimeric Analysis of the Multicomponent Multidrug Efflux Transporters from Gram-Negative Bacteria
Tikhonova, E. B., Wang, Q., & Zgurskaya, H. I. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.23.6499-6507.2002 · Cited by 160
Bohnert, J. A., Karamian, B. A., & Nikaido, H. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00620-10 · Cited by 155
Self-citationJellen-Ritter, A., & Kern, W. V. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1467-1472.2001 · Cited by 150
Self-citationNon-Target Gene Mutations in the Development of Fluoroquinolone Resistance in Escherichia coli
Kern, W. V., Oethinger, M. D., Jellen-Ritter, A., & Levy, S. B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.814-820.2000 · Cited by 140
Self-citationReversal of resistance in microorganisms by help of non-antibiotics
Kristiansen, J. E., Hendricks, O., Delvin, T., Butterworth, T. S., Aagaard, L., Christensen, J. B., Flores, V. C., & Keyzer, H. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm071 · Cited by 109
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Li, X.-Z., Plésiat, P., & Nikaido, H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00117-14 · Cited by 1,648
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“confirmed by the synergistic effect of some SSRIs in combination with antibiotics; as well as their effects against some antibiotic-resistant bacteria (Bohnert et al., 2011; Munoz-Bellido et al., 1996, 2000).”
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Venter, H., Mowla, R., Ohene‐Agyei, T., & Ma, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00377 · Cited by 286
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Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5006-5 · Cited by 266
Macêdo, D. S., Filho, A. J. M. C., de Sousa, C. N. S., Quevedo, J., Barichello, T., Júnior, H. V. N., & de Lucena, D. F. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.012 · Cited by 269
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Dreier, J., & Ruggerone, P. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00660 · Cited by 202
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Cussotto, S., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5185-8 · Cited by 176
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Chait, Y. A., Mottawea, W., Tompkins, T. A., & Hammami, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-74934-9 · Cited by 158
Skonieczna‐Żydecka, K., Marlicz, W. M., Misera, A., Koulaouzidis, A., & Łoniewski, I. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120521 · Cited by 151
Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance
Ayaz, M., Subhan, F., Ahmed, J., Khan, A.-U., Ullah, F., Ullah, I., Ali, G., Syed, N.-I.-H., & Hussain, S. (2015) · Journal of Biological Research-Thessaloniki · doi:10.1186/s40709-015-0028-1 · Cited by 147
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Lagadinou, M., Onisor, M. O., Rigas, A., Musetescu, D.-V., Gkentzi, D., Assimakopoulos, S. F., Panos, G. Z., & Marangos, M. N. (2020) · Antibiotics · doi:10.3390/antibiotics9030107 · Cited by 126
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Halverson, T., & Alagiakrishnan, K. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1808239 · Cited by 125
The gut microbiome in social anxiety disorder: evidence of altered composition and function
Butler, M., Bastiaanssen, T. F. S., Long-Smith, C. M., Mörkl, S., Berding, K., Ritz, N. L., Strain, C., Patangia, D. V., Patel, S. H., Stanton, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02325-5 · Cited by 120
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Viveiros, M., Martins, M., Rodrigues, L., Machado, D., Couto, I., Aínsa, J. A., & Amaral, L. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.89 · Cited by 96
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Maier, L., & Typas, A. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.11.001 · Cited by 95
McGovern, A. S., Hamlin, A. S., & Winter, G. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419877954 · Cited by 98
Richmond, E. K., Rosi, E. J., Lee, S., Thompson, R. M., & Grace, M. (2016) · Freshwater Science · doi:10.1086/687841 · Cited by 74
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Dong, Z., Shen, X., Hao, Y., Li, J., Xu, H., Li, Y., & Kuang, W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.813075 · Cited by 73
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Alagiakrishnan, K., Morgadinho, J., & Halverson, T. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1330903 · Cited by 79
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Foletto, V. S., da Rosa, T. F., Serafin, M. B., Bottega, A., & Hörner, R. (2021) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2021.106380 · Cited by 63
Ramsteijn, A. S., Jašarević, E., Houwing, D. J., Bale, T. L., & Olivier, J. D. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1705728 · Cited by 70
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Jampílek, J. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.05.006 · Cited by 62
Nzakizwanayo, J., Scavone, P., Jamshidi, S., Hawthorne, J. A., Pelling, H., Dedi, C., Salvage, J. P., Hind, C. K., Guppy, F. M., Barnes, L.-M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12445-w · Cited by 56
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Xu, F., Xie, Q., Kuang, W., & Dong, Z. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01362-8 · Cited by 59
Adamson, D. H., Krikstopaityte, V., & Coote, P. J. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv111 · Cited by 54
Rácz, B., & Spengler, G. (2023) · Antibiotics · doi:10.3390/antibiotics12010137 · Cited by 55
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Lawler, A. J., Ricci, V., Busby, S. J. W., & Piddock, L. J. V. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt069 · Cited by 53
Shi, D., Hao, H., Wei, Z., Yang, D., Yin, J., Li, H., Chen, Z., Yang, Z., Chen, T., Zhou, S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2021.2018901 · Cited by 53
Ilhan, Z. E., Brochard, V., Lapaque, N., Auvin, S., & Lepage, P. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105664 · Cited by 48
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Siriyong, T., Voravuthikunchai, S. P., & Coote, P. J. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2348-9 · Cited by 41
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Evrensel, A., & Tarhan, N. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110138 · Cited by 39
Makino, Y., Oe, C., Iwama, K., Suzuki, S., Nishiyama, A., Hasegawa, K., Okuda, H., Hirata, K., Ueno, M., Kawaji, K., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03555-x · Cited by 36
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Li, L., Kromann, S., Olsen, J. E., Svenningsen, S. W., & Olsen, R. H. (2017) · The Journal of Antibiotics · doi:10.1038/ja.2017.78 · Cited by 36
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Richter, K., den Driessche, F. V., & Coenye, T. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160056 · Cited by 41
Dombach, J. L., Quintana, J. L. J., Nagy, T. A., Wan, C., Crooks, A. L., Yu, H., Su, C., Yu, E. W., Shen, J., & Detweiler, C. S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009119 · Cited by 34
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Li, G., Hou, Y., Zhang, C., Zhou, X., Bao, F., Yang, Y. H., Chen, L., & Yu, D. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.05.003 · Cited by 38
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Bohnert, J. A., Schuster, S., & Kern, W. V. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010083 · Cited by 29
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Lima, M. L., Abengózar, M. Á., Nachér-Vázquez, M., Martinez‐Alcazar, M. P., Barbas, C., Tempone, A. G., López‐Gonzálvez, Á., & Rivas, L. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01928-18 · Cited by 29
Misera, A., Łoniewski, I., Palma, J., Kulaszyńska, M., Czarnecka, W., Kaczmarczyk, M., Liśkiewicz, P., Samochowiec, J., & Skonieczna‐Żydecka, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1125022 · Cited by 28
Foletto, V. S., Serafin, M. B., Bottega, A., da Rosa, T. F., Machado, C. D. S., Coelho, S. S., & Hörner, R. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02507-6 · Cited by 27
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Thompson, L., Nikolakakis, K. C., Pan, S., Reed, J. L., Knight, R. D., & Ruby, E. G. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13684 · Cited by 25
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McCusker, M. P., Ferreira, D. A., Cooney, D., Alves, B. M., Fanning, S., Pagès, J., Martins, M., & Davin‐Regli, A. (2018) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2018.10.009 · Cited by 21
Kiecka, A., & Szczepanik, M. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00423-7 · Cited by 19
Phan, T.-V., Nguyen, V.-T.-V., Nguyen, C.-H.-H., Vu, T., Tran, T., Le, M.-T., Trinh, D.-T. T., Tran, V.-H., & Thai, K. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2175381 · Cited by 18
Nanjan, P., & Bose, V. (2024) · Current Drug Research Reviews · doi:10.2174/0125899775271214240112071830 · Cited by 18
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Michaelis, L., Berg, L., & Maier, L. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.004 · Cited by 20
Hug, C., Zhang, X., Guan, M., Krauss, M. K. V., Bloch, R. J., Schulze, T., Reinecke, T., Hollert, H., & Brack, W. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3083 · Cited by 16
Osman, M. E.-S., El-Hendawy, H. H., El-All, S. M. A., Hassan, A. M., & Mahmoud, D. E. (2018) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2018.81206 · Cited by 16
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Islamieh, D. I., Afshar, D., Yousefi, M., & Esmaeili, D. (2018) · International Journal of Medical Reviews · doi:10.29252/ijmr-050303 · Cited by 15
Schump, M. D., Fox, D., Bertozzi, C. R., & Riley, L. W. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01639-16 · Cited by 16
Badie, O. H., Basyony, A. F., & Samir, R. (2022) · Microorganisms · doi:10.3390/microorganisms10101973 · Cited by 14
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Liu, X.-J., Kang, L.-Q., Liu, Y., Li, H., & Peng, X. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.01.022 · Cited by 14
Ahmed, S., Jordan, R. L., Isseroff, R. R., & Lenhard, J. R. (2024) · Antibiotics · doi:10.3390/antibiotics13121165 · Cited by 12
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Gashaw, M., Marame, Z. H., Abera, M., & Ali, S. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s305992 · Cited by 12
Endo, T. H., Santos, M. H. D. M., Scandorieiro, S., Gonçalves, B. C., Vespero, E. C., Perugini, M. R. E., Pavanelli, W. R., Nakazato, G., & Kobayashi, R. K. T. (2025) · Antibiotics · doi:10.3390/antibiotics14010051 · Cited by 11
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Boustany, A., Feuerstadt, P., & Tillotson, G. (2024) · Advances in Therapy · doi:10.1007/s12325-024-02972-0 · Cited by 7
Schuster, S., Vavra, M., Wirth, D. A. N., & Kern, W. V. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03045-23 · Cited by 7
Self-citationDing, L., Chen, X., Lv, Y., Peng, Q., Wang, R., Yang, B., & Wei, L. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04362-8 · Cited by 9
Lalani, F. S., Young, E. H., Panchal, R. M., & Reveles, K. R. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa353 · Cited by 7
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Matejczyk, M., Ofman, P., Wiater, J., Świsłocka, R., Kondzior, P., & Lewandowski, W. (2023) · Materials · doi:10.3390/ma16093600 · Cited by 6
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptidesPreprint
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Bohnert, J. A., & Kern, W. V. (2016) · Springer eBooks · doi:10.1007/978-3-319-39658-3_29 · Cited by 5
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Sarmah, A., Shethia, N., Rao, P., Rath, S. L., Jobby, R., Aswathanarayan, J. B., & Ravichandran, V. (2025) · ChemistrySelect · doi:10.1002/slct.202500206 · Cited by 3
Guedes, G. M. D. M., de Araújo, E. S., Ribeiro, K. V. C., Pereira, V. C., Soares, A. C. C. F., Freitas, A. S., Amando, B. R., Cordeiro, R. D. A., Rocha, M. F. G., Sidrim, J. J. C., et al. (2023) · Future Microbiology · doi:10.2217/fmb-2022-0272 · Cited by 3
When antidepressants meet the gut microbiota: implications and challenges
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Dong, Z., Han, K. Q., Xie, Q., Lin, C., Shen, X., Hao, Y., Li, J., Xu, H., He, L., Yu, T., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.07.106 · Cited by 4
Kromann, S., Hvidtfeldt, A., Boyé, M., Sørensen, D. B., Jørgensen, S., Nielsen, J. P., & Olsen, R. H. (2019) · BMC Microbiology · doi:10.1186/s12866-018-1383-5 · Cited by 3
Durgadevi, R., Alexpandi, R., Swasthika, R., Balu, P., Abirami, G., Ashok Kumar, K., Suganthi, M., Malaiyandi, J., Durairaj, R., & Arumugam, V. R. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01284-9 · Cited by 2
Davies, J. M., Teh, J. J., Ewais, T., & Begun, J. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae121 · Cited by 2
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Vakili, O., Motamed, M., Taghizadeh, M., & Khatami, S. H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05751-w · Cited by 2
Phan, T.-V., Nguyen, C.-H.-H., & Nguyen, V.-T.-V. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.11081 · Cited by 2
Arrieta‐Ortiz, M. L., Pan, M., Kaur, A., Srinivas, V., Dash, A., Immanuel, S. R. C., & Baliga, N. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.275693 · Cited by 2
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptidesPreprint
Lee, K. K., Łapińska, U., Tolle, G., Phetsang, W., Verderosa, A. D., Invergo, B. M., Westley, J., Bebes, A., Yuecel, R., O’Neill, P. A., et al. (2024) · eLife · doi:10.7554/elife.99752.1 · Cited by 2
Olivares, D. V. F., Halverson, T., & Alagiakrishnan, K. (2026) · Future Pharmacology · doi:10.3390/futurepharmacol6020030 · Cited by 1
Kumbhar, N., Aparna, M. A., Nimal, S. K., Shewale, P., Barale, S. S., & Gacche, R. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15232-0.00021-7 · Cited by 1
The Evolution of Antimycobacterial Agents from Non
Amaral, L., Kristiansen, J. E., & WAINWRIGHT, M. S. (2012)
Pinto, É. G. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.99.2016.tde-19042016-150040
Metadata
- Authors
- Bohnert, J. A., Szymaniak-Vits, M., Schuster, S., & Kern, W. V.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Bohnert, Jürgen A.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-23
- Volume
- 66
- Issue
- 9
- Pages
- 2057-2060
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2129997370
- Cited by
- 114
- References
- 15
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 13 · 2021: 2 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 7 · 2013: 4 · 2012: 3
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- selective serotonin reuptake inhibitors, sertraline, efflux pump inhibition, RND efflux pumps, Escherichia coli, antimicrobial synergy, acrAB, Kahramanmaraş, AcrB, antibiotic resistance, tetracycline, oxacillin, linezolid, clarithromycin
- MeSH terms
- Anti-Bacterial Agents, DNA-Binding Proteins, Dose-Response Relationship, Drug, Drug Synergism, Escherichia coli, Fluorescent Dyes, Membrane Proteins, Microbial Sensitivity Tests, Oxazines, Protein Kinases, Gene Expression Regulation, Bacterial, Selective Serotonin Reuptake Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Sertraline, Drug Resistance, Multiple, Bacterial, Escherichia coli Proteins
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