Repositioning of fluoxetine and paroxetine: Study of potential antibacterial activity and its combination with ciprofloxacin
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Fluoxetine is active against bacteria, fungi, and a virus.
“Fluoxetine, an SSRI, was found to be active against bacteria, fungi [50,56,64,67], and, interestingly, even a virus.”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [67]
Paroxetine inhibits bacterial growth at 110-282 μM (40-101 μg/mL).
“| Paroxetine (third generation of selective serotonin reuptake inhibitors) | C. albicans, E. coli, A. baumanii | 110-282 µM (40-101 µg/mL) | Inhibits cell growth; promotes mitochondrial inhibits bacterial growth. depolarization and membrane damage in yeast, | [56,58,67-69] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [67]
Paroxetine inhibits cell growth in C. albicans, E. coli, and A. baumanii at 110-282 μM (40-101 μg/mL).
“| Paroxetine (third generation of selective serotonin reuptake inhibitors) | C. albicans, E. coli, A. baumanii | 110-282 µM (40-101 µg/mL) | Inhibits cell growth; promotes mitochondrial inhibits bacterial growth. depolarization and membrane damage in yeast, | [56,58,67-69] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [67]
Paroxetine promotes mitochondrial depolarization and membrane damage in yeast at 110-282 μM (40-101 μg/mL).
“| Paroxetine (third generation of selective serotonin reuptake inhibitors) | C. albicans, E. coli, A. baumanii | 110-282 µM (40-101 µg/mL) | Inhibits cell growth; promotes mitochondrial inhibits bacterial growth. depolarization and membrane damage in yeast, | [56,58,67-69] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [67]
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Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications
Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54 · see citing works
- Authors
- Foletto, V. S., Serafin, M. B., Bottega, A., da Rosa, T. F., Machado, C. D. S., Coelho, S. S., & Hörner, R.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Corresponding author
- Hörner, Rosmari
- Venue
- Medicinal Chemistry Research
- Published
- 2020-01-18
- Volume
- 29
- Issue
- 3
- Pages
- 556-563
- ISSN
- 1054-2523 (ISSN-L)
- 1554-8120
- OpenAlex
- W2999935883
- Cited by
- 27
- References
- 21
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicinal Chemistry Research (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- drug repurposing, fluoxetine, paroxetine, ciprofloxacin, antibacterial activity, selective serotonin reuptake inhibitors, multidrug resistance, Acinetobacter baumannii, Escherichia coli, combination therapy, synergistic effect, bactericidal activity, clinical isolates
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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