The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
MIC-based dose adjustment: facts and fables
Open accessAbstract
Over recent decades, several publications have described optimization procedures for antibiotic therapy in the individual patient based on antimicrobial MIC values. Most methods include therapeutic drug monitoring and use a single MIC determination plus the relevant pharmacokinetics/pharmacodynamics to adjust the dose to optimize antimicrobial drug exposure and antibacterial effects. However, the use of an MIC obtained by a single MIC determination is inappropriate. First, routine clinical laboratories cannot determine MICs with sufficient accuracy to guide dosage owing to the inherent assay variation in the MIC test. Second, the variation in any MIC determination, whatever method is used, must be accounted for. If dose adjustments are made based on therapeutic drug monitoring and include MIC determinations, MIC variation must be considered to prevent potential underdosing of patients. We present the problems and some approaches that could be used in clinical practice.
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Self-citationAugmented Renal Clearance: Implications for Antibacterial Dosing in the Critically Ill
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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics
Wicha, S. G., Märtson, A., Nielsen, E. I., Koch, B. C. P., Friberg, L. E., Alffenaar, J., Minichmayr, I. K., & the International Society of Anti‐Infective Pharmacology (ISAP), T. P. S. G. O. T. E. S. O. C. M. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2202 · Cited by 322
Metadata
- Authors
- Mouton, J. W., Muller, A. E., Canton, R., Giske, C. G., Kahlmeter, G., & Turnidge, J.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-12-05
- Volume
- 73
- Issue
- 3
- Pages
- 564-568
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2771362836
- Cited by
- 328
- References
- 16
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: MIC-based dose adjustment: facts and fables. https://app.cochat.ai/papers/10.1093/jac/dkx427
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- Mouton, J. W., Muller, A. E., Canton, R., Giske, C. G., Kahlmeter, G., & Turnidge, J. (2018). MIC-based dose adjustment: facts and fables. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkx427
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