The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Mechanisms Underlying Postmortem Redistribution of Drugs: A Review
Open accessAbstract
Postmortem drug concentrations do not necessarily reflect concentrations at the time of death, as drug levels may vary according to the sampling site and the interval between death and specimen collection. These site- and time-dependent variations are called "postmortem redistribution" (PMR). The underlying mechanisms are complex and of different types. Passive drug release from drug reservoirs such as the gastrointestinal tract, liver, lungs, and myocardium may occur immediately after death and, later on, cell autolysis and the putrefactive process participate in redistribution. There is evidence that basic lipophilic drugs with a large distribution volume are particularly susceptible to PMR. Nevertheless, this cannot explain the actual PMR of some nonbasic, nonlipophilic drugs. In addition, the persistence of drug metabolism immediately after death must be considered. Consequently, it is of great importance to analyze specimens from different sampling sites in order to detect potential PMR and avoid misinterpretation of results.
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Cited by
Skopp, G. (2010) · Forensic Science, Medicine, and Pathology · doi:10.1007/s12024-010-9150-4 · Cited by 176
Jones, A. W., Holmgren, A., & Ahlner, J. (2016) · Forensic Science International · doi:10.1016/j.forsciint.2016.08.015 · Cited by 41
Metabolites of Heroin in Several Different Post-mortem Matrices
Thaulow, C. H., Øiestad, Å. M. L., Rogde, S., Karinen, R., Brochmann, G. W., Andersen, J. M., Høiseth, G., Handal, M., Mørland, J., Arnestad, M., et al. (2018) · Journal of Analytical Toxicology · doi:10.1093/jat/bky002 · Cited by 27
Kamphuis, A. E. M., Borra, L. C. P., van der Hulst, R., Kloos, D.-P., Rijken, D. J., Bosman, I. J., & Touw, D. J. (2021) · Forensic Science International · doi:10.1016/j.forsciint.2021.111094 · Cited by 17
Metadata
- Authors
- Pélissier-Alicot, A.-L., Gaulier, J.-M., Champsaur, P., & Marquet, P.
- Venue
- Journal of Analytical Toxicology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-11-01
- Volume
- 27
- Issue
- 8
- Pages
- 533-544
- ISSN
- 0146-4760 (ISSN-L)
- 1945-2403
- OpenAlex
- W2146309768
- Cited by
- 299
- References
- 33
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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