Cited by 144Forensic Toxicology and Drug AnalysisPsychedelics and Drug StudiesSynthesis and bioactivity of alkaloids

A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation.

Sklerov, Jason, Levine, Barry, Moore, Karla A., King, Theodore, Fowler, David·2005·Journal of Analytical Toxicology

Abstract

A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic tryptamines is presented. No anatomic cause of death was found at autopsy. Toxicologic analysis of the heart blood identified N,N-dimethyltryptamine (0.02 mg/L), 5-methoxy-N,N-dimethyltryptamine (1.88 mg/L), tetrahydroharmine (0.38 mg/L), harmaline (0.07 mg/L), and harmine (0.17 mg/L). All substances were extracted by a single-step n-butyl chloride extraction following alkalinization with borate buffer. Detection and quantitation was performed using liquid chromatography-electrospray mass spectrometry. The medical examiner ruled that the cause of death was hallucinogenic amine intoxication, and the manner of death was undetermined.

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Crossref · 10.1093/jat/29.8.838

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Authors
Sklerov, J., Levine, B., Moore, K. A., King, T., & Fowler, D.
Affiliations
State of Maryland (US)
Corresponding author
Levine, Barry
Venue
Journal of Analytical Toxicology
Published
2005-11-01
Volume
29
Issue
8
Pages
838-841
ISSN
  • 0146-4760 (ISSN-L)
  • 1945-2403
OpenAlex
W2159917347
Cited by
144
References
15
Citations by year
2026: 8 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 4
FWCI
4.61
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Analytical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Synthesis and bioactivity of alkaloids
Keywords
5-MeO-DMT, ayahuasca, β-carbolines, tetrahydroharmine, harmaline, harmine, fatal poisoning, death investigation, postmortem toxicology
MeSH terms
Adult, Chromatography, Liquid, Humans, Male, Methoxydimethyltryptamines, Mass Spectrometry, Fatal Outcome, Banisteriopsis

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