The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1
Open accessAbstract
Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation of miR-148a and miR-152 and their impact on BC cells. Due to the hypermethylation of CpG island, the expression levels of both miR-148a and miR-152 (miR-148a/152) are decreased in BC tissues and cells. DNMT1, the DNA methyltransferase 1 for the maintenance methylation, is aberrantly up-regulated in BC and its overexpression is responsible for hypermethylation of miR-148a and miR-152 promoters. Intriguingly, we found that DNMT1 expression, which is one of the targets of miR-148a/152, is inversely correlated with the expression levels of miR-148a/152 in BC tissues. Those results lead us to propose a negative feedback regulatory loop between miR-148a/152 and DNMT1 in BC. More importantly, we demonstrate that IGF-IR and IRS1, often overexpressed in BC, are two novel targets of miR-148a/152. Overexpression of miR-148a or miR-152 significantly inhibits BC cell proliferation, colony formation, and tumor angiogenesis via targeting IGF-IR and IRS1 and suppressing their downstream AKT and MAPK/ERK signaling pathways. Our results suggest a novel miR-148a/152-DNMT1 regulatory circuit and reveal that miR-148a and miR-152 act as tumor suppressors by targeting IGF-IR and IRS1, and that restoration of miR-148a/152 expression may provide a strategy for therapeutic application to treat BC patients.
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Interplay between the miRNome and the epigenetic machinery: Implications in health and disease
Poddar, S., Kesharwani, D., & Datta, M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25819 · Cited by 57
Analysis of miRNA expression profiles in breast cancer using biclustering
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Breast Cancer and the Other Non-Coding RNAs
Dvorská, D., Braný, D., Ňachajová, M., Halašová, E., & Danková, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063280 · Cited by 38
Metadata
- Authors
- Xu, Q., Jiang, Y., Yin, Y., Li, Q., He, J., Jing, Y., Qi, Y.-T., Xu, Q., Li, W., Lu, B., Peiper, S. S., Jiang, B.-H., & Liu, L.-Z.
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-29
- Volume
- 5
- Issue
- 1
- Pages
- 3-13
- ISSN
- 1674-2788 (ISSN-L)
- 1759-4685
- OpenAlex
- W2107684325
- Cited by
- 285
- References
- 50
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, Q., Jiang, Y., Yin, Y., Li, Q., He, J., Jing, Y., Qi, Y.-T., Xu, Q., Li, W., Lu, B., Peiper, S. S., Jiang, B.-H., & Liu, L.-Z. (2013). A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Journal of Molecular Cell Biology. https://doi.org/10.1093/jmcb/mjs049
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