Cited by 772Autophagy in Disease and TherapyCellular transport and secretionCalcium signaling and nucleotide metabolism

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The lysosome: from waste bag to potential therapeutic target

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Appelqvist, Hanna, Wäster, Petra, Kågedal, Katarina, Öllinger, Karin·2013·Journal of Molecular Cell Biology

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Abstract

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior. They are central for degradation and recycling of macromolecules delivered by endocytosis, phagocytosis, and autophagy. In contrast to the rather simplified view of lysosomes as waste bags, nowadays lysosomes are recognized as advanced organelles involved in many cellular processes and are considered crucial regulators of cell homeostasis. The function of lysosomes is critically dependent on soluble lysosomal hydrolases (e.g. cathepsins) as well as lysosomal membrane proteins (e.g. lysosome-associated membrane proteins). This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death. Regulation of lysosomal biogenesis and function via the transcription factor EB (TFEB) will also be discussed. In addition, lysosomal contribution to diseases, including lysosomal storage disorders, neurodegenerative disorders, cancer, and cardiovascular diseases, is presented.

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Authors: Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K.
Affiliations: Linköping University (SE)
Corresponding author: Öllinger, Karin
ORCID: Appelqvist, Hanna
Wäster, Petra
Kågedal, Katarina
Öllinger, Karin
Venue: Journal of Molecular Cell Biology
Publisher: Oxford University Press (OUP)
Published: 2013-08
Volume: 5
Issue: 4
Pages: 214-226
ISSN: 1674-2788 (ISSN-L)
1759-4685
DOI: 10.1093/jmcb/mjt022
OpenAlex: W2152462290
Cited by: 772
References: 201
Citations by year: 2026: 34 · 2025: 43 · 2024: 49 · 2023: 47 · 2022: 59 · 2021: 71 · 2020: 64 · 2019: 72 · 2018: 75 · 2017: 97 · 2016: 71 · 2015: 57 · 2014: 30 · 2013: 3
FWCI: 6.36
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Cancerfonden
Vetenskapsrådet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosomes, lysosomal enzymes, cathepsins, lysosomal membrane proteins, lysosome-associated membrane protein, autophagy, endocytosis, phagocytosis, macromolecule degradation, plasma membrane repair, cholesterol homeostasis, cell death, lysosomal biogenesis, TFEB, lysosomal storage disease, neurodegenerative diseases, cancer, cardiovascular disease
MeSH terms: Cell Membrane, Endocytosis, Homeostasis, Humans, Lysosomes, Models, Biological, Proteins, Lysosomal Storage Diseases, Apoptosis

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The lysosome: from waste bag to potential therapeutic target

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