Cited by 260RNA and protein synthesis mechanismsRNA Research and SplicingPI3K/AKT/mTOR signaling in cancer

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IRES-mediated cap-independent translation, a path leading to hidden proteome

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Yang, Yun, Wang, Zefeng·2019·Journal of Molecular Cell Biology

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Abstract

Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) can serve as an alternative mechanism for protein production. Many IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate translation by recruiting different trans-acting factors. Although the mechanisms of translation initiation driven by viral IRESs are relatively well understood, the existence of cellular IRESs is still under debate due to the limitations of translation reporter systems used to assay IRES activities. A recent screen identified > 1000 putative IRESs from viral and human mRNAs, expanding the scope and mechanism for cap-independent translation. Additionally, a large number of circular RNAs lacking free ends were identified in eukaryotic cells, many of which are found to be translated through IRESs. These findings suggest that IRESs may play a previously unappreciated role in driving translation of the new type of mRNA, implying a hidden proteome produced from cap-independent translation.

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Authors: Yang, Y., & Wang, Z.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Yang, Yun
Wang, Zefeng
ORCID: Yang, Yun
Wang, Zefeng
Venue: Journal of Molecular Cell Biology
Publisher: Oxford University Press (OUP)
Published: 2019-09-03
Volume: 11
Issue: 10
Pages: 911-919
ISSN: 1674-2788 (ISSN-L)
1759-4685
DOI: 10.1093/jmcb/mjz091
PMC: PMC6884710
OpenAlex: W2971386099
Cited by: 260
References: 80
Citations by year: 2026: 30 · 2025: 45 · 2024: 53 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 17 · 2019: 1
FWCI: 2.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Molecular Cell Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Youth Innovation Promotion Association CAS and Shanghai Science and Technology Committee Rising-Star Program (19QA1410500)
CAS Pioneer 100-Talent Program
National Natural Science Foundation of China (31870814, 91753135, 31730110, 31661143031, 31570823)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: internal ribosome entry site, cap-independent translation, circular RNA, translation initiation, trans-acting factors
MeSH terms: Internal Ribosome Entry Sites, Humans, Models, Biological, Ribosomes, Protein Biosynthesis, Proteome

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IRES-mediated cap-independent translation, a path leading to hidden proteome

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