Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
Open accessAbstract
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of physiologically relevant processes is still unclear. Here we performed expression profiling of circRNAs during in vitro differentiation of murine and human myoblasts, and we identified conserved species regulated in myogenesis and altered in Duchenne muscular dystrophy. A high-content functional genomic screen allowed the study of their functional role in muscle differentiation. One of them, circ-ZNF609, resulted in specifically controlling myoblast proliferation. Circ-ZNF609 contains an open reading frame spanning from the start codon, in common with the linear transcript, and terminating at an in-frame STOP codon, created upon circularization. Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes.
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A small number of circRNAs can be translated despite lacking both terminal 5′ and 3′ ends.
“Emerging evidence indicates that a small number of circRNAs can be translated despite lacking both terminal 5 ′ and 3 ′ ends [53,55,56].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [53]
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · see citing works
Self-citationNatural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985 · see citing works
Ballard, D. H., & Brown, C. M. (1982) · Cited by 5,235 · see citing works
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884 · see citing works
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388 · see citing works
Differential analysis of gene regulation at transcript resolution with RNA-seq
Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492 · see citing works
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083 · see citing works
Self-citationDetecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,685 · see citing works
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N. J., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,457 · see citing works
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.027 · Cited by 2,423 · cited 4× · see citing works
“Since circ-ZNF609 is highly expressed in neural tissues (Rybak-Wolf et al., 2015), we applied an established neuronal differentiation protocol (Wichterle and Peljto, 2008), and we checked for the expression of the FLAG-tagged circZNF609 RNA by northern blot in WT cells and in the F/D clone.”
BackgroundMethodInfluentialSelf-citationSanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296 · see citing works
The RNA Binding Protein Quaking Regulates Formation of circRNAs
Conn, S. J., Pillman, K. A., Toubia, J., Conn, V. M., Salmanidis, M., Phillips, C. A., Roslan, S., SCHREIBER, A. W., Gregory, P. A., & Goodall, G. J. (2015) · Cell · doi:10.1016/j.cell.2015.02.014 · Cited by 2,187 · see citing works
Zheng, Q., Bao, C., Guo, W., Li, S., Chen, J., Chen, B., Luo, Y., Lyu, D., Li, Y., Shi, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms11215 · Cited by 2,045 · see citing works
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953 · see citing works
5′ UTR m6A Promotes Cap-Independent Translation
Meyer, K. D., Patil, D. P., Zhou, J. L., Zinoviev, A., Skabkin, M. A., Elemento, O., Pestova, T. V., Qian, S., & Jaffrey, S. R. (2015) · Cell · doi:10.1016/j.cell.2015.10.012 · Cited by 1,812 · see citing works
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
Du, W. W., Yang, W., Liu, E., Yang, Z., Dhaliwal, P., & Yang, B. B. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw027 · Cited by 1,699 · see citing works
Translational control in stress and apoptosis
Holčı́k, M., & Sonenberg, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1618 · Cited by 1,366 · see citing works
Dynamic m6A mRNA methylation directs translational control of heat shock response
Zhou, J. L., Wan, J., Gao, X., Zhang, X., Jaffrey, S. R., & Qian, S. (2015) · Nature · doi:10.1038/nature15377 · Cited by 1,226 · see citing works
Zhao, X., Yang, Y., Sun, B.-F., Shi, Y. X., Yang, X., Xiao, W., Hao, Y.-J., Ping, X., Chen, Y., Wang, W., et al. (2014) · Cell Research · doi:10.1038/cr.2014.151 · Cited by 1,186 · see citing works
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149 · see citing works
Circular transcripts of the testis-determining gene Sry in adult mouse testis
Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,100 · see citing works
A protein interaction network for pluripotency of embryonic stem cells
Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D. N., Theunissen, T. W., & Orkin, S. H. (2006) · Nature · doi:10.1038/nature05284 · Cited by 1,094 · see citing works
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996 · see citing works
Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing
Jackson, A. L., Burchard, J., Leake, D., Reynolds, A., Schelter, J. M., Guo, J., Johnson, J. M., Lim, L. P., Karpilow, J. M., Nichols, K. E., et al. (2006) · RNA · doi:10.1261/rna.30706 · Cited by 790 · see citing works
Exon Circularization Requires Canonical Splice Signals
Starke, S., Jost, I., Roßbach, O., Schneider, T. P., Schreiner, S., Hung, L.-H., & Bindereif, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.002 · Cited by 768 · see citing works
Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs
Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766 · see citing works
Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations
Guarnerio, J., Bezzi, M., Jeong, J. C., Paffenholz, S. V., Berry, K., Naldini, M. M., Lo‐Coco, F., Tay, Y., Beck, A. H., & Pandolfi, P. P. (2016) · Cell · doi:10.1016/j.cell.2016.03.020 · Cited by 739 · see citing works
Suzuki, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl151 · Cited by 687 · see citing works
Efficient backsplicing produces translatable circular mRNAs
Wang, Y., & Wang, Z. (2014) · RNA · doi:10.1261/rna.048272.114 · Cited by 665 · see citing works
Kramer, M. C., Liang, D., Tatomer, D. C., Gold, B., March, Z. M., Cherry, S. R., & Wilusz, J. E. (2015) · Genes & Development · doi:10.1101/gad.270421.115 · Cited by 494 · see citing works
Circular RNAs: splicing’s enigma variations
Hentze, M. W., & Preiss, T. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.53 · Cited by 455 · see citing works
Rolling Circle Translation of Circular RNA in Living Human Cells
Abe, N., Matsumoto, K., Nishihara, M., Nakano, Y., Shibata, A., Maruyama, H., Shuto, S., Matsuda, A., Yoshida, M., Ito, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep16435 · Cited by 444 · see citing works
Cellular IRES-mediated translation
Komar, A. A., & Hatzoglou, M. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14472 · Cited by 418 · see citing works
Systematic discovery of cap-independent translation sequences in human and viral genomes
Weingarten-Gabbay, S., Elias-Kirma, S., Nir, R., Gritsenko, A. A., Stern-Ginossar, N., Yakhini, Z., Weinberger, A., & Segal, E. (2016) · Science · doi:10.1126/science.aad4939 · Cited by 334 · see citing works
Circular RNAs: a new frontier in the study of human diseases
Chen, Y., Li, C., Tan, C., & Liu, X. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103758 · Cited by 293 · see citing works
Cap-dependent and cap-independent translation in eukaryotic systems
Merrick, W. C. (2004) · Gene · doi:10.1016/j.gene.2004.02.051 · Cited by 276 · see citing works
Legnini, I., Morlando, M., Mangiavacchi, A., Fatica, A., & Bozzoni, I. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.012 · Cited by 231 · see citing works
Self-citationCap-dependent and cap-independent translation in eukaryotic systems
Merrick, W. C. (2004) · Gene · doi:10.1016/s0378-1119(04)00142-8 · Cited by 215 · see citing works
Chen, P., Weinmann, L., Gaidatzis, D., Pei, Y., Zavolan, M., Tuschl, T., & Meister, G. (2007) · RNA · doi:10.1261/rna.789808 · Cited by 206 · see citing works
Yang, P., Qiu, Z., Jiang, Y., Dong, L., Yang, W., Gu, C., Li, G., & Zhu, Y. T. (2016) · Oncotarget · doi:10.18632/oncotarget.11523 · Cited by 199 · see citing works
Novel splicing mechanism for the ribosomal RNA intron in the archaebacterium desulfurococcus mobilis
Kjems, J., & Garrett, R. A. (1988) · Cell · doi:10.1016/s0092-8674(88)80014-x · Cited by 150 · see citing works
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self‐renewal
Gagliardi, A., Mullin, N. P., Tan, Z. Y., Colby, D., Kousa, A. I., Halbritter, F., Weiss, J. T., Felker, A., Bezstarosti, K., Favaro, R., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.161 · Cited by 134 · see citing works
Differentiation of Mouse Embryonic Stem Cells to Spinal Motor Neurons
Wichterle, H., & Peljto, M. (2008) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc01h01s5 · Cited by 115 · see citing works
A site-specific endonuclease encoded by a typical archaeal intron.
Dalgaard, J. Z., Garrett, R. A., & Belfort, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5414 · Cited by 85 · see citing works
Defective smooth muscle development in qkI‐deficient mice
Li, Z., Takakura, N., Oike, Y., Imanaka, T., Araki, K., Suda, T., Kaname, T., Kondo, T., Abe, K., & Yamamura, K. (2003) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2003.00712.x · Cited by 77 · see citing works
Cazzella, V., Martone, J., Pinnarò, C., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2012.178 · Cited by 46 · see citing works
Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609
Reed, N. P., Henderson, M. A., Oltz, E. M., & Aune, T. M. (2012) · Genes and Immunity · doi:10.1038/gene.2012.47 · Cited by 13 · see citing works
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Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619 · see citing works
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Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.022 · Cited by 475 · see citing works
Dube, U., Del-Aguila, J. L., Li, Z., Budde, J. P., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M. V., Farias, F., Norton, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0501-5 · Cited by 345 · see citing works
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Yang, Y., & Wang, Z. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz091 · Cited by 260 · see citing works
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Huang, R., Zhang, Y., Bai, Y., Han, B., Ju, M., Chen, B., Yang, L., Wang, Y., Zhang, H., Zhang, H., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.018 · Cited by 159 · see citing works
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- Authors
- Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., Sthandier, O., Fatica, A., Santini, T., Andronache, A., Wade, M., Laneve, P., Rajewsky, N., & Bozzoni, I.
- Affiliations
- Institute of Molecular Biology and Pathology (IT)
- Italian Institute of Technology (IT)
- Max Delbrück Center (DE)
- Corresponding author
- Bozzoni, Irene
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 66
- Issue
- 1
- Pages
- 22-37.e9
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC5387670
- OpenAlex
- W2601436215
- Cited by
- 2,173
- References
- 52
- Citations by year
- 2026: 95 · 2025: 166 · 2024: 174 · 2023: 222 · 2022: 291 · 2021: 409 · 2020: 325 · 2019: 251 · 2018: 170 · 2017: 66
- FWCI
- 92.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Funders
- ERC-2013 (AdG 340172-MUNCODD)
- Telethon (GGP16213)
- Epigen-Epigenomics Flagship Project (59377)
- Parent Project Italia
- AFM-Telethon (17835)
- AriSLA full grant 2014 (ARCI)
- Fondazione Roma
- PRIN
- Human Frontiers Science Program Award (RGP0009/2014)
- EMBO (141-2014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- circular RNA, myogenesis, myoblast proliferation, Duchenne muscular dystrophy, open reading frames, cap-independent translation, polysomes
- MeSH terms
- RNA, Circular, Animals, Genotype, HeLa Cells, Humans, Male, Muscle Proteins, Phenotype, RNA, RNA Caps, RNA Splicing, Transfection, Protein Biosynthesis, Signal Transduction, Open Reading Frames, Sequence Analysis, RNA, Muscular Dystrophy, Duchenne, Muscle Development, Myoblasts, Skeletal, RNA Interference, Cell Proliferation, Mice, High-Throughput Nucleotide Sequencing
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