Cited by 260RNA and protein synthesis mechanismsRNA Research and SplicingPI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

IRES-mediated cap-independent translation, a path leading to hidden proteome

Open access

Yang, Yun, Wang, Zefeng·2019·Journal of Molecular Cell Biology

Open this paper in CoChat — free account Open PDF

Abstract

Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) can serve as an alternative mechanism for protein production. Many IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate translation by recruiting different trans-acting factors. Although the mechanisms of translation initiation driven by viral IRESs are relatively well understood, the existence of cellular IRESs is still under debate due to the limitations of translation reporter systems used to assay IRES activities. A recent screen identified > 1000 putative IRESs from viral and human mRNAs, expanding the scope and mechanism for cap-independent translation. Additionally, a large number of circular RNAs lacking free ends were identified in eukaryotic cells, many of which are found to be translated through IRESs. These findings suggest that IRESs may play a previously unappreciated role in driving translation of the new type of mRNA, implying a hidden proteome produced from cap-independent translation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jmcb/mjz091

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Four groups of viral IRESs. Viral IRESs can be classified into four groups based on their structures and the requirement of ITAFs and IFs. Generally, IRESs with more compact structures require less auxiliary protein factors.CC BY · PubMed Central

Figure 2 Mechanism of translation initiation driven by cellular IRES. (A) Type I cellular IRES. The cis-elements in the cellular IRESs are bound by the ITAFs. These ITAFs will directly interact with the 40S ribosomal subunit or recruit the 40S ribosomal subunit through the ‘bridge’—IFs. Finally, the 60S ribosomal subunit is recruited to start translation. (B) Type II cellular IRES. Cellular IRESs contain the short cis-elements that can base pair to the 18S rRNA. Therefore, these cellular IRESs can directly interact with 40S ribosomal subunit by base-pairing between itself and 18S rRNA and recruit 60S ribosomal subunit to start the translation.CC BY · PubMed Central

Figure 3 Reporter systems using in IRES study. (A) Bicistronic reporter system. The most popular reporter system is used to examine IRES activity. In the plasmid, two ORFs are inserted into downstream of the transcription promoter, and the IRES is inserted between these two ORFs. During translation, the first ORF is translated through cap-dependent translation whereas the second ORF is translated by cap-independent translation. This reporter can be in vitro transcribed into RNA and used for the in vitro or in vivo translation system (left panel). There are three reasons that may introduce the false positive activity of the ‘IRES’ sequence: first, the cryptic promoter activity; second, the cryptic splicing sites; and third, translation readthrough (right panel). (B) circRNA reporter system. The circRNA reporter is inserted into a single exon containing two split GFP ORFs in a reversed order and two flanking introns with complement elements. After transcription, the circRNA will be generated through back-splicing and then translated into protein through IRES-dependent translation (left panel). The transcription readthrough produces a very long linear RNA concatemer including two or more exons with the split GFP ORFs. This RNA concatemer may be spliced into the mature linear mRNA containing a whole ORF. Therefore, the transcription readthrough will introduce the false discovery activity of IRESs (right panel).CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304
GENCODE reference annotation for the human and mouse genomes
Frankish, A., Diekhans, M., Ferreira, A.-M., Johnson, R., Jungreis, I., Loveland, J. E., Mudge, J. M., Sisu, C., Wright, J. C., Armstrong, J. C., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky955 · Cited by 3,006
Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., Sthandier, O., Fatica, A., Santini, T., Andronache, A., Wade, M., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.017 · Cited by 2,173
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953
Cell-Type Specific Features of Circular RNA Expression
Salzman, J., Chen, R. E., Olsen, M. N., Wang, P., & Brown, P. O. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003777 · Cited by 1,952
Extensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855
Mass-spectrometry-based draft of the human proteome
Wilhelm, M., Schlegl, J., Hahne, H., Gholami, A. M., Lieberenz, M., Savitski, M. M., Ziegler, E., Butzmann, L., Gessulat, S., Marx, H., et al. (2014) · Nature · doi:10.1038/nature13319 · Cited by 1,820
5′ UTR m6A Promotes Cap-Independent Translation
Meyer, K. D., Patil, D. P., Zhou, J. L., Zinoviev, A., Skabkin, M. A., Elemento, O., Pestova, T. V., Qian, S., & Jaffrey, S. R. (2015) · Cell · doi:10.1016/j.cell.2015.10.012 · Cited by 1,812

Show all 80 references

Sorted by citations

Translation and functional roles of circular RNAs in human cancer
Lei, M., Zheng, G., Ning, Q., Zheng, J., & Dong, D. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1135-7 · Cited by 814
Nanomaterial Delivery Systems for mRNA Vaccines
Buschmann, M. D., Carrasco, M. J., Alishetty, S., Paige, M., Alameh, M. G., & Weissman, D. (2021) · Vaccines · doi:10.3390/vaccines9010065 · Cited by 582
Mitochondria-mediated oxidative stress during viral infection
Foo, J., Bellot, G. L., Pervaiz, S., & Alonso, S. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2021.12.011 · Cited by 328
COVID-19 mRNA vaccines: Platforms and current developments
Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308
Pervasive translation of circular RNAs driven by short IRES-like elements
Fan, X., Yang, Y., Chen, C., & Wang, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31327-y · Cited by 241
Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
Gómez-Aguado, I., Rodríguez-Castejón, J., Vicente-Pascual, M., Rodríguez‐Gascón, A., Solinís, M. Á., & del Pozo‐Rodríguez, A. (2020) · Nanomaterials · doi:10.3390/nano10020364 · Cited by 229
The dark proteome: translation from noncanonical open reading frames
Wright, B. W., Yi, Z., Weissman, J. S., & Chen, J. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.10.010 · Cited by 214
Translation of noncoding RNAs and cancer
Zhou, B., Yang, H., Yang, C. H., Bao, Y., Yang, S., Liu, J., & Xiao, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.002 · Cited by 151
Circular RNA translation: novel protein isoforms and clinical significance
Wen, S., Qadir, J., & Yang, B. B. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.03.003 · Cited by 142
Translation of small downstream ORFs enhances translation of canonical main open reading frames
Wu, Q., Wright, M., Gogol, M., Bradford, W. D., Zhang, N., & Bazzini, A. (2020) · The EMBO Journal · doi:10.15252/embj.2020104763 · Cited by 133
A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease
Clarke, J.-P. W. E., Thibault, P. A., Salapa, H. E., & Levin, M. C. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.659610 · Cited by 138
TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence
Huang, W., Ling, Y., Zhang, S., Xia, Q., Cao, R., Fan, X., Fang, Z., Wang, Z., & Zhang, G. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa823 · Cited by 127
IL‐6–induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma
Li, H., Lan, T., Liu, H., Liu, C., Dai, J., Xu, L., Cai, Y., Hou, G., Xie, K., Liao, M., et al. (2021) · Hepatology · doi:10.1002/hep.32232 · Cited by 124
The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
Mendez, A. S., Ly, M., González-Sánchez, A. M., Hartenian, E., Ingolia, N. T., Cate, J. H. D., & Glaunsinger, B. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109841 · Cited by 110
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
Nisar, S., Bhat, A. A., Singh, M. K., Karedath, T., Rizwan, A., Hashem, S., Bagga, P., Reddy, R. D., Jamal, F., Shahab Uddin, M. S., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.617281 · Cited by 100
Circular RNAs’ cap-independent translation protein and its roles in carcinomas
He, L., Man, C., Xiang, S., Yao, L., Wang, X., & Fan, Y. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01417-4 · Cited by 90
mRNA therapeutics: New vaccination and beyond
Wei, H. Y., Zheng, L., & Wang, Z. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.02.022 · Cited by 77
An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma
Feng, Z., Zhang, X., Zhou, J., Li, Q., Chu, L., Di, G., Xu, Z., Chen, Q., Wang, M., Jiang, X., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00650-8 · Cited by 70
Plant translational reprogramming for stress resilience
Son, S., & Park, S. R. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1151587 · Cited by 68
Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice
Zhou, J., Ye, T., Yang, Y., Li, E., Zhang, K., Wang, Y., Chen, S., Hu, J., Zhang, K., Liu, F., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.04.028 · Cited by 68
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
Ryan, C. S., & Schröder, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1033684 · Cited by 57
A flexible, efficient, and scalable platform to produce circular RNAs as new therapeuticsPreprint
Wei, H. Y., Chen, C., Zhang, K., Li, Z., Wei, T., Tang, C., Yang, Y., & Wang, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.31.494115 · Cited by 60
Socialized mitochondria: mitonuclear crosstalk in stress
Kim, K. H., & Lee, C. B. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01211-4 · Cited by 62
Therapeutic mRNA Engineering from Head to Tail
Jia, L., & Qian, S. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00541 · Cited by 51
The Ins and Outs of Messenger RNA Electroporation for Physical Gene Delivery in Immune Cell-Based Therapy
Campillo-Davó, D., Laere, M. D., Roex, G., Versteven, M., Flumens, D., Berneman, Z. N., Tendeloo, V. F. V., Anguille, S., & Lion, E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030396 · Cited by 50
CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation
Li, Y., Wang, Z., Yang, J., Sun, Y., He, Y., Wang, Y., Chen, X., Liang, Y., Zhang, N., Wang, X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02019-6 · Cited by 48
Biological functions and applications of circRNAs—next generation of RNA-based therapy
Sun, M., & Yang, Y. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad031 · Cited by 47
Cellular oxidants and the proteostasis network: balance between activation and destruction
Ulfig, A., & Jakob, U. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.07.001 · Cited by 45
Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors
Tickner, Z. J., & Farzan, M. (2021) · Pharmaceuticals · doi:10.3390/ph14060554 · Cited by 40
Chimeric Peptides/Proteins Encoded by circRNA: An Update on Mechanisms and Functions in Human Cancers
Khan, F. A., Nsengimana, B., Khan, N. H., Song, Z., Ngowi, E. E., Wang, Y., Zhang, W., & Ji, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.781270 · Cited by 41
Translation regulation in response to stress
Williams, T. D., & Rousseau, A. (2024) · FEBS Journal · doi:10.1111/febs.17076 · Cited by 45
Discordant Activity of Kaempferol Towards Dengue Virus and Japanese Encephalitis Virus
Care, C., Sornjai, W., Jaratsittisin, J., Hitakarun, A., Wikan, N., Triwitayakorn, K., & Smith, D. R. (2020) · Molecules · doi:10.3390/molecules25051246 · Cited by 40
False-positive IRESes from Hoxa9 and other genes resulting from errors in mammalian 5′ UTR annotations
(2022) · doi:10.1073/pnas.2122170119 · Cited by 35
The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells
Steen, N. V. D., Lyu, Y., Hitzler, A. K., Becker, A. C., Seiler, J., & Diederichs, S. (2020) · Cancers · doi:10.3390/cancers12051091 · Cited by 37
Application prospect of circular RNA-based neoantigen vaccine in tumor immunotherapy
Li, M., Wang, Y., Wu, P., Zhang, S., Gong, Z., Liao, Q., Guo, C., Wang, F., Li, Y., Zeng, Z., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216190 · Cited by 35
A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
Kienzle, L., Bettinazzi, S., Choquette, T., Brunet, M. A., Khorami, H. H., Jacques, J., Moreau, M., Roucou, X., Landry, C. R., Angers, A., et al. (2023) · BMC Biology · doi:10.1186/s12915-023-01609-y · Cited by 39
Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation
Liu, Y., Cui, J., Hoffman, A. R., & Hu, J. (2022) · Cell Proliferation · doi:10.1111/cpr.13367 · Cited by 33
The important regulatory roles of circRNA‑encoded proteins or peptides in cancer pathogenesis (Review)
Zhang, L., Gao, H., Li, X., Yu, F., & Li, P. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5607 · Cited by 33
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
Bjork, R. T., Mortimore, N. P., Loganathan, S., & Zarnescu, D. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.840357 · Cited by 36
So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes
Slobodin, B., & Dikstein, R. (2020) · EMBO Reports · doi:10.15252/embr.202050799 · Cited by 30
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression
Li, H., Jiao, W., Song, J., Wang, J., Chen, G., Li, D., Wang, X., Bao, B., Du, X., Yang, C., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02898-5 · Cited by 32
DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication
Abdullah, S. W., Wu, J., Zhang, Y., Bai, M., Guan, J., Liu, X., Sun, S., & Guo, H. (2021) · Viruses · doi:10.3390/v13091765 · Cited by 29
Long noncoding RNAs with peptide‐encoding potential identified in esophageal squamous cell carcinoma: KDM4A‐AS1‐encoded peptide weakens cancer cell viability and migratory capacity
Zhou, B., Wu, Y., Cheng, P., & Wu, C. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13424 · Cited by 28
Current Practice in Bicistronic IRES Reporter Use: A Systematic Review
van den Akker, G., Zacchini, F., Housmans, B., van der Vloet, L., Caron, M. M. J., Montanaro, L., & Welting, T. J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105193 · Cited by 27
Role of circular RNAs in colorectal tumor microenvironment
Ashraf, J. V., Nair, V. S., Saleh, R., & Elkord, E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111351 · Cited by 26
Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms
Zhao, H., Zhou, Q., & Li, X. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.04.002 · Cited by 25
DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance
Zhang, H., Mañán-Mejías, P. M., Miles, H. N., Putnam, A. A., MacGillivray, L. R., & Ricke, W. A. (2024) · Cancers · doi:10.3390/cancers16061131 · Cited by 25
Circular RNA ITCH: An Emerging Multifunctional Regulator
Su, K., Qiao, Y., Dai, X., & Liu, O. (2022) · Biomolecules · doi:10.3390/biom12030359 · Cited by 23
When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2
Gao, J., Tang, Y., Hu, W., & Zheng, C. (2022) · Journal of Virology · doi:10.1128/jvi.00136-22 · Cited by 23
CircSMARCA5: A key circular RNA in various human diseases
Zhu, Y., Huang, G., Li, S.-H., Xiong, H., Chen, R., Zuo, L., & Liu, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.921306 · Cited by 24
Unlocking the potential of circular RNA vaccines: a bioinformatics and computational biology perspective
Liu, X., Wang, S., Sun, Y., Liao, Y., Jiang, G., Sun, B., Yu, J., & Zhao, D. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105638 · Cited by 24
RAN proteins in neurodegenerative disease: Repeating themes and unifying therapeutic strategies
Guo, S., Nguyen, L., & Ranum, L. P. W. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.11.001 · Cited by 22
mRNA delivery technologies: Toward clinical translation
Gómez-Aguado, I., Rodríguez-Castejón, J., Beraza-Millor, M., Rodríguez‐Gascón, A., del Pozo‐Rodríguez, A., & Solinís, M. Á. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.010 · Cited by 23
Mechanism underlying circRNA dysregulation in the TME of digestive system cancer
Wu, Z., Yu, X., Zhang, S., He, Y., & Guo, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951561 · Cited by 22
Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis
Ho, H. T., Peischard, S., Strutz‐Seebohm, N., & Seebohm, G. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000470 · Cited by 20
The clinical progress and challenges of mRNA vaccines
Yu, M., Wang, N., Zhu, J., & Lin, Y. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1894 · Cited by 23
Combination of Oncolytic Virotherapy with Different Antitumor Approaches against Glioblastoma
Ageenko, A. B., Vasileva, N. S., Richter, V. A., & Kuligina, E. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042042 · Cited by 21
Are There Hidden Genes in DNA/RNA Vaccines?
Beaudoin, C. A., Bartas, M., Volná, A., Pečínka, P., & Blundell, T. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.801915 · Cited by 21
Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers
Jacko, D., Schaaf, K., Masur, L., Windoffer, H., Aussieker, T., Schiffer, T., Zacher, J., Bloch, W., & Gehlert, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105431 · Cited by 20
Cap-Independent Circular mRNA Translation Efficiency
Deviatkin, A. A., Simonov, R. A., Trutneva, K. A., Maznina, A. A., Soroka, A. B., Kogan, A. A., Feoktistova, S. G., Khavina, E. M., Mityaeva, O. N., & Volchkov, P. (2023) · Vaccines · doi:10.3390/vaccines11020238 · Cited by 21
Non-canonical translation in cancer: significance and therapeutic potential of non-canonical ORFs, m6A-modification, and circular RNAs
Deng, X., Yu, Y. V., & Jin, Y. N. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02185-y · Cited by 23
Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design
Wąsińska-Kałwa, M., Mamot, A., Czubak, K., Frankowska, K., Rajkiewicz, A. A., Śpiewla, T., Warmiński, M., Pilch, Z., Szulc-Gasiorowska, M., Siekan, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61775-1 · Cited by 27
Role of RNA binding proteins of the Drosophila behavior and human splicing (DBHS) family in health and cancer
Takeiwa, T., Ikeda, K., Horie, K., & Inoue, S. (2024) · RNA Biology · doi:10.1080/15476286.2024.2332855 · Cited by 18
Translation initiation and its relevance in colorectal cancer
Minnee, E., & Faller, W. J. (2020) · FEBS Journal · doi:10.1111/febs.15690 · Cited by 20
G-Quadruplex Regulation of VEGFA mRNA Translation by RBM4
Niu, K., Zhang, X., Song, Q., & Feng, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020743 · Cited by 19
Thrown for a (stem) loop: How RNA structure impacts circular RNA regulation and function
Busa, V. F., & Leung, A. K. L. (2021) · Methods · doi:10.1016/j.ymeth.2021.02.019 · Cited by 17
Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases
Liu, H., Hao, W., Yang, J., Zhang, Y., Wang, X., & Zhang, C. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.10.015 · Cited by 17
Single-molecule visualization of mRNA circularization during translation
Kim, B., Seol, J., Kim, Y. K., & Lee, J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00933-1 · Cited by 16
Recent Progress on Circular RNAs in the Development of Skeletal Muscle and Adipose Tissues of Farm Animals
Yan, S., Pei, Y., Li, J., Tang, Z., & Yang, Y. (2023) · Biomolecules · doi:10.3390/biom13020314 · Cited by 17
Structure of saguaro cactus virus 3′ translational enhancer mimics 5′ cap for eIF4E binding
Ojha, M., Vogt, J., Das, N. K., Redmond, E., Singh, K., Banna, H. A., Sadat, T., & Koirala, D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313677121 · Cited by 17
Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer
Radanova, M. A., Mihaylova, G., Nazifova-Tasinova, N. F., Levkova, M., Tasinov, O., Ivanova, D. P., Mihaylova, Z., & Donev, I. S. (2021) · Cancers · doi:10.3390/cancers13143395 · Cited by 16
IRES-mediated Pichia pastoris cell-free protein synthesis
Wang, Y., Wang, T., Chen, X., & Lu, Y. (2023) · Bioresources and Bioprocessing · doi:10.1186/s40643-023-00653-4 · Cited by 16
Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story
Khuroo, M. S. (2023) · Viruses · doi:10.3390/v15081745 · Cited by 16
Control of translation by eukaryotic mRNA transcript leaders—Insights from high‐throughput assays and computational modeling
Akirtava, C., & McManus, C. J. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1623 · Cited by 15
Newly discovered mechanisms that mediate tumorigenesis and tumour progression: circRNA ‐encoded proteins
Wu, C., Wang, S., Cao, T., Huang, T., Xu, L., Wang, J., Li, Q., Wang, Y., Qian, L., Xu, L., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17751 · Cited by 15
Poly(U)‐specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element‐mediated inhibition
Lee, H., Fu, C., Lin, C., Hu, J., Huang, T., Lo, K., Tsai, H., Sheu, J., & Tsai, H. (2021) · The EMBO Journal · doi:10.15252/embj.2019104123 · Cited by 16
Anomalous HIV-1 RNA, How Cap-Methylation Segregates Viral Transcripts by Form and Function
Boris‐Lawrie, K., Singh, G., Osmer, P. S., Zucko, D., Staller, S., & Heng, X. (2022) · Viruses · doi:10.3390/v14050935 · Cited by 15
The Genomic 3′ UTR of Flaviviruses Is a Translation Initiation Enhancer
Berzal‐Herranz, A., Berzal-Herranz, B., Ramos-Lorente, S. E., & Romero‐López, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158604 · Cited by 15
Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome
Jing, T., Wu, Y., Wan, A., Ge, C., Chen, Z., & Du, Y. (2023) · Biomolecules · doi:10.3390/biom13071101 · Cited by 15
DeepIRES: a hybrid deep learning model for accurate identification of internal ribosome entry sites in cellular and viral mRNAs
Zhao, J., Chen, Z., Zhang, M., Zou, L., He, S., Liu, J., Wang, Q., Song, X., & Wu, J. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae439 · Cited by 18
A novel protein encoded by circCOPA inhibits the malignant phenotype of glioblastoma cells and increases their sensitivity to temozolomide by disrupting the NONO–SFPQ complex
Peng, D., Cheng, W., Jing, B., Yu, R., Zhang, Z., & Han, L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07010-z · Cited by 14
eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer
Boyer, J. A., Rosen, E. Y., Sharma, M., Dorso, M. A., Mai, N., Amor, C., Reiter, J., Kannan, R., Gadal, S., Xu, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424286122 · Cited by 16
Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRES
Hoque, M. E., Mahendran, T., & Basu, S. (2022) · Biomolecules · doi:10.3390/biom12020314 · Cited by 12
Translation of Circular RNAs: Functions of Translated Products and Related Bioinformatics Approaches
Hwang, J. Y., Kook, T. L., Paulus, S. M., & Park, J. W. (2023) · Current Bioinformatics · doi:10.2174/1574893618666230505101059 · Cited by 14
Translation Inhibition Mediated by Interferon-Stimulated Genes during Viral Infections
Smart, A., Gilmer, O., & Caliskan, N. (2024) · Viruses · doi:10.3390/v16071097 · Cited by 13
CircFAT1 Promotes Lung Adenocarcinoma Progression by Sequestering miR-7 from Repressing IRS2-ERK-mediated CCND1 Expression
Peng, H., Zhang, W., Dong, H., Yuan, J., Li, Y., Li, F., Yu, D., Guan, Y. A., & Zhang, F. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70889 · Cited by 14
Development, Characterization, and Application of Two Reporter-Expressing Recombinant Zika Viruses
Yun, S.-I., Song, B.-H., Woolley, M., Frank, J. C., Julander, J. G., & Lee, Y.-M. (2020) · Viruses · doi:10.3390/v12050572 · Cited by 13
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Zitzmann, C., Dächert, C., Schmid, B., van der Schaar, H. M., van Hemert, M. J., Perelson, A. S., van Kuppeveld, F. J. M., Bartenschlager, R. F. W., Binder, M., & Kaderali, L. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010423 · Cited by 12
Ribonucleic Acid-Mediated Control of Protein Translation Under Stress
Payea, M. J., Dar, S. A., Malla, S., & Maragkakis, M. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0233 · Cited by 11
Sensing of H2O2-induced oxidative stress by the UPF factor complex is crucial for activation of catalase-3 expression in Neurospora
Shen, S., Zhang, C., Meng, Y., Cui, G., Wāng, Y., Liu, X., & He, Q. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010985 · Cited by 12
Diphthamide – a conserved modification of eEF2 with clinical relevance
Schaffrath, R., & Brinkmann, U. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.11.008 · Cited by 12
Exploring the Potential and Advancements of Circular RNA Therapeutics
Wang, L., Wang, L., Dong, C., Liu, J., Cui, G., Gao, S., & Liu, Z. (2025) · Exploration · doi:10.1002/exp.20240044 · Cited by 15
Post‐Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs
Lancaster, C. L., Moberg, K. H., & Corbett, A. H. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70007 · Cited by 14
Multiple novel functions of circular RNAs in diabetes mellitus
Tehrani, S. S., Goodarzi, G., Panahi, G., Maniati, M., & Meshkani, R. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1933047 · Cited by 11
Translational and post-translational control of human naïve versus primed pluripotency
Chen, C., Zhang, X., Wang, Y., Chen, W., Chen, W., Dan, S., She, S., Hu, W., Dai, J., Hu, J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103645 · Cited by 12
Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5′-Terminal Region of p53 mRNA
Janecki, D. M., Świątkowska, A., Szpotkowska, J., Urbanowicz, A., Kabacińska, M., Szpotkowski, K., & Ciesiołka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413306 · Cited by 11
SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
Korneeva, N. L., Khalil, M. I., Ghosh, I., Fan, R., Arnold, T., & Benedetti, A. D. (2023) · Virology Journal · doi:10.1186/s12985-023-02021-2 · Cited by 11
Viral RNA capping: Mechanisms and antiviral therapy
Chen, S., Jiang, Z., Li, Q., Pan, W., Chen, Y., & Liu, J. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29622 · Cited by 10
Circadian regulation of translation
Lyu, J., Zhuang, Y., & Lin, Y. (2024) · RNA Biology · doi:10.1080/15476286.2024.2408524 · Cited by 11
Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors
Ito, H., Machida, K., Hasumi, M., Ueyama, M., Nagai, Y., Imataka, H., & Taguchi, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-50188-z · Cited by 9

Authors: Yang, Y., & Wang, Z.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Yang, Yun
Wang, Zefeng
ORCID: Yang, Yun
Wang, Zefeng
Venue: Journal of Molecular Cell Biology
Publisher: Oxford University Press (OUP)
Published: 2019-09-03
Volume: 11
Issue: 10
Pages: 911-919
ISSN: 1674-2788 (ISSN-L)
1759-4685
DOI: 10.1093/jmcb/mjz091
PMC: PMC6884710
OpenAlex: W2971386099
Cited by: 260
References: 80
Citations by year: 2026: 30 · 2025: 45 · 2024: 53 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 17 · 2019: 1
FWCI: 2.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Molecular Cell Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Youth Innovation Promotion Association CAS and Shanghai Science and Technology Committee Rising-Star Program (19QA1410500)
CAS Pioneer 100-Talent Program
National Natural Science Foundation of China (31870814, 91753135, 31730110, 31661143031, 31570823)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: internal ribosome entry site, cap-independent translation, circular RNA, translation initiation, trans-acting factors
MeSH terms: Internal Ribosome Entry Sites, Humans, Models, Biological, Ribosomes, Protein Biosynthesis, Proteome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IRES-mediated cap-independent translation, a path leading to hidden proteome

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks