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Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes
Open accessAbstract
The effects of propionate, a product of intestinal fiber fermentation, on fatty acid and sterol synthesis were studied in isolated rat hepatocytes. Fatty acid synthesis, as measured by tritium incorporation from 3H2O, was inhibited in the presence of 1 mmol/L propionate with no substrate additions or additions of acetate, butyrate, lactate or oleate. Incorporation of [1-14C]acetate into fatty acids was also inhibited in the presence of propionate. Although propionate markedly depressed [1-14C]acetate incorporation into sterols in hepatocyte preparations, tritium incorporation from 3H2O into sterols was not inhibited, indicating that overall sterol synthesis was not affected. Thus, in vitro, the effect of propionate on lipid metabolism is apparently limited to inhibition of de novo fatty acid synthesis.
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Cited by
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739
Oliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614
Effect of Diet and Dietary Components on the Composition of the Gut Microbiota
Beam, A., Clinger, E., & Hao, L. (2021) · Nutrients · doi:10.3390/nu13082795 · Cited by 576
Metadata
- Authors
- Nishina, P. M., & Freedland, R. A.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 120
- Issue
- 7
- Pages
- 668-673
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1835824024
- Cited by
- 238
- References
- 0
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nishina, P. M., & Freedland, R. A. (1990). Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes. The Journal of Nutrition. https://doi.org/10.1093/jn/120.7.668
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