Magnesium Deficiency Modulates the Insulin Signaling Pathway in Liver but Not Muscle of Rats

Reis, Marise A.B.; Reyes, Felix G.R.; Saad, Mário J.A.; Velloso, Lício A.

doi:10.1093/jn/130.2.133

Cited by 28Magnesium in Health and DiseaseMetabolism, Diabetes, and CancerTrace Elements in Health

Magnesium Deficiency Modulates the Insulin Signaling Pathway in Liver but Not Muscle of Rats

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Reis, Marise A.B., Reyes, Felix G.R., Saad, Mário J.A., Velloso, Lício A.·2000·The Journal of Nutrition

DOI 10.1093/jn/130.2.133

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Abstract

Altered insulin secretion and sensitivity have been observed in Mg-deficient animals. However, the effects of Mg deficiency and supplementation on intracellular signaling events triggered by insulin are unknown. Therefore, we studied the early steps of insulin action in muscle and liver of rats fed Mg-deficient (DF-6, DF-11) or control (CO-6, CO-11) diets for 6 or 11 wk, respectively, and Mg-deficient or control diets for 6 wk, followed by Mg supplementation for 5 wk (SDF and SCO groups, respectively). There were no differences in the glucose disappearance rate (K(itt)) or insulin signaling between CO-6 and DF-6 rats. Between the two groups of rats fed for 11 wk, the DF-11 group had a significantly greater K(itt). SDF and SCO rats had K(itt) that did not differ from CO-11 rats, but that were significantly lower than in DF-11 rats. In the latter rats, insulin receptor and insulin receptor substrate-1 protein and phosphorylation levels were elevated in liver and there was a greater association between the insulin receptor substrate-1 and p85 subunit of phosphatidyl-inositol 3-kinase compared with CO-11 rats. There were no differences in the early steps of insulin action in SDF and control rats. These results suggest that the normal insulin sensitivity maintained by Mg supplementation and the increased insulin sensitivity produced by a long period of Mg deprivation may result, at least in part, from alterations in or maintenance of the early molecular steps of insulin action in hepatic tissue.

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Magnesium may play a role in insulin secretion in insulin-resistant patients, as the condition has been associated with hypomagnesemia in diabetic patients.
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Authors: Reis, M. A. B., Reyes, F. G. R., Saad, M. J. A., & Velloso, L. A.
Affiliations: Universidade Estadual de Campinas (UNICAMP) (BR)
ORCID: Saad, Mário J.A.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2000-02
Volume: 130
Issue: 2
Pages: 133-138
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/130.2.133
OpenAlex: W2150233632
Cited by: 28
References: 47
Citations by year: 2026: 2 · 2024: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 1
FWCI: 1.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8396 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: hypomagnesemia, magnesium supplementation, insulin signaling, insulin receptor, IRS-1, phosphatidylinositol 3-kinase, liver, skeletal muscle, insulin sensitivity, glucose disappearance rate
MeSH terms: Analysis of Variance, Animals, Diet, Electrophoresis, Polyacrylamide Gel, Glucose, Insulin, Liver, Magnesium, Magnesium Deficiency, Male, Muscles, Phosphorylation, Receptor, Insulin, Rats, Wistar, Rats

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Magnesium Deficiency Modulates the Insulin Signaling Pathway in Liver but Not Muscle of Rats

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