Historical perspective on garlic and cardiovascular disease
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Cardiovascular disease is a complex and multifactorial disease characterized by such factors as high cholesterol, hypertension, reduced fibrinolysis, increase in blood-clotting time and increased platelet aggregation. Dietary therapy is the first step in the treatment of hyperlipidemia; garlic has been used medicinally for centuries and is still included in the traditional medicine of many cultures. Historically, there has been great interest in the role of garlic in reducing cardiovascular risk factors. Evidence from numerous studies points to the fact that garlic can bring about the normalization of plasma lipids, enhancement of fibrinolytic activity, inhibition of platelet aggregation and reduction of blood pressure and glucose. However, some contradictory results have also emerged as a result of methodological shortcomings, the use of different formulations/preparations of garlic and different time scales of the studies. Accordingly, further clinical studies are required in which standardized formulations of garlic with known compositions can be used. Such formulations (e.g., Aged Garlic Extract) are now available and are being investigated. Evidence obtained from these studies indicates that garlic has potential in the prevention and control of cardiovascular disorders and is beneficial when taken as a dietary supplement.
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Garlic formulations have been broadly used to inhibit and relieve cardiovascular disorders such as hypertension, arrhythmia, thrombosis, hyperlipidemia, and atherosclerosis.
“Garlic formulations have been broadly used to inhibit and relieve cardiovascular disorders such as hypertension, arrhythmia, thrombosis, hyperlipidemia, and atherosclerosis [19,120].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [19]
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- Authors
- Rahman, K.
- Affiliations
- Liverpool John Moores University (GB)
- Corresponding author
- Rahman, Khalid
- ORCID
- Rahman, Khalid
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 131
- Issue
- 3
- Pages
- 977S-979S
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2147693600
- Cited by
- 215
- References
- 24
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 14 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- garlic, cardiovascular disease, hyperlipidemia, plasma lipids, fibrinolysis, platelet aggregation, blood pressure, blood glucose, aged garlic extract, dietary supplements, traditional medicine, cardiovascular risk factors
- MeSH terms
- Arteriosclerosis, Cardiovascular Diseases, Garlic, Hemodynamics, Humans, Hyperlipidemias, Phytotherapy, Plant Extracts, Plants, Medicinal, Platelet Aggregation
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