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Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats
Open accessAbstract
Stressful events result in the alteration of gut permeability and sensitivity. Lactobacillus paracasei NCC2461 (Lpa) therapy prevents antibiotic-induced visceral hyperalgesia in mice. This study aimed at evaluating the influence of 3 probiotic strains: Bifidobacterium lactis NCC362, Lactobacillus johnsonii NCC533, and Lpa on stress-mediated alterations of colorectal hyperalgesia, on gut paracellular permeability and whether bacteria and/or bacterial products present in the spent culture medium (SCM) were involved in the antinociceptive properties of the effective strain. Rat pups were separated from their mothers 3 h/d during postnatal d 2-14. At wk 13, gut paracellular permeability was determined as a percentage of urinary excreted (51)Cr-EDTA and visceral sensitivity to colorectal distension (CRD), assessed by abdominal muscle electromyography. Visceral sensitivity was also analyzed in adults rats subjected to partial restraint stress (PRS, 2 h restriction of body movements). Rats received either the probiotics resuspended in SCM or fresh growth medium as control for 2 wk. Maternal deprivation significantly increased colonic sensitivity in response to CRD and enhanced gut paracellular permeability compared with control rats. Only Lpa treatment significantly improved stress-induced visceral pain and restored normal gut permeability. Similarly, among the 3 probiotics tested, only Lpa prevented PRS-mediated visceral hyperalgesia. Both bacteria and bacterial products present in Lpa SCM were required for the antinociceptive properties against PRS. This study illustrates strain-specific effects and suggests a synergistic interplay between L. paracasei bacteria and bacterial products generated during fermentation and growth that confers the ability to suppress PRS-induced hypersensitivity in rats.
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“The use of probiotics, particularly in animal models, also demonstrates that their secreted products or metabolites can modulate contractility of intestinal smooth muscle and visceral sensitivity.59–61”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [61]
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Metadata
- Authors
- Eutamene, H., Lamine, F., Chabo, C., Theodorou, V., Rochat, F., Bergonzelli, G. E., Corthésy-Theulaz, I., Fioramonti, J., & Bueno, L.
- Affiliations
- Ecole d'Ingénieurs de PURPAN (FR)
- Nestlé (Switzerland) (CH)
- Corresponding author
- Bueno, Lionel
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 137
- Issue
- 8
- Pages
- 1901-1907
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2127775549
- Cited by
- 169
- References
- 60
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 14
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus paracasei, probiotics, intestinal permeability, visceral hypersensitivity, visceral pain, maternal deprivation, restraint stress, colorectal distension, Bifidobacterium animalis subsp. lactis, Lactobacillus johnsonii, spent culture medium, bacterial products, antinociception, strain-specific effects
- MeSH terms
- Animals, Bifidobacterium, Intestines, Lactobacillus, Pain, Permeability, Restraint, Physical, Stress, Physiological, Rats, Wistar, Rats
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