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Chromosome Studies on Normal and Leukemic Human Leukocytes
Abstract
Chromosome studies were made on myeloblasts obtained from the peripheral blood of 4 patients (3 males, 1 female) with acute or chronic granulocytic leukemia and on leukocytes from 3 healthy individuals (1 male, 2 females). The cells were grown in culture for 2 to 4 days before examination. Both in normal and in leukemic cells, the predominant metaphase chromosome number was 46. However, idiogram analyses revealed a definite abnormality, probably involving the Y chromosome, in the 2 cases of chronic granulocytic leukemia. No chromosome abnormality was distinguishable in the 2 cases of acute leukemia (1 male, 1 female) investigated. The results indicate that in some leukemic human leukocytes small but definite chromosomal changes are demonstrable.
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Citations
Cited by
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Soto, A. M., & Sonnenschein, C. (2004) · BioEssays · doi:10.1002/bies.20087 · Cited by 295
Chromosomal Abnormalities in Cancer
Fröhling, S., & Döhner, H. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0803109 · Cited by 229
Cancer Vaccines, Adjuvants, and Delivery Systems
Paston, S. J., Brentville, V. A., Symonds, P., & Durrant, L. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.627932 · Cited by 200
Wu, E. Q., Johnson, S., Beaulieu, N., Arana, M., Bollu, V., Guo, A., Coombs, J., Feng, W., & Cortes, J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007990903396469 · Cited by 126
Commonality but Diversity in Cancer Gene Fusions
Rabbitts, T. H. (2009) · Cell · doi:10.1016/j.cell.2009.04.034 · Cited by 73
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1960-07
- Volume
- 25
- Pages
- 85-109
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2275311108
- Cited by
- 1,069
- References
- 0
- FWCI
- 33.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chromosome Studies on Normal and Leukemic Human Leukocytes. (1960). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/25.1.85
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