Cited by 230Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Chromosomal Abnormalities in Cancer

Fröhling, Stefan, Döhner, Hartmut·2008·New England Journal of Medicine

Abstract

This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–small-cell lung cancer. The authors point out that some of the chromosomal abnormalities have revealed targets for cancer treatment, and others have clinical application in the diagnosis of certain types of neoplasms and in the formulation of a prognosis.

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Crossref · 10.1056/nejmra0803109

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94 of 94 references verified0 citation errors · 0 not checkable

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Authors
Fröhling, S., & Döhner, H.
Affiliations
  • Brigham and Women's Hospital (US)
  • University Hospital Ulm (DE)
Venue
New England Journal of Medicine
Published
2008-08-14
Volume
359
Issue
7
Pages
722-734
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W1975410130
Cited by
229
References
94
Citations by year
2025: 8 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 19 · 2012: 18
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromosomal abnormalities, cancer, hematologic malignancies, solid tumors, prostate cancer, non-small cell lung cancer, cancer therapy targets, tumor diagnosis, prognosis
MeSH terms
Chromosome Aberrations, Chromosomes, Human, Humans, Neoplasms, Protein-Tyrosine Kinases, Transcription Factors, Translocation, Genetic, Gene Expression Regulation, Neoplastic

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