The Protovirus Hypothesis: Speculations on the Significance of RNA-Directed DNA Synthesis for Normal Development and for Carcinogenesis

Howard M. Temin

doi:10.1093/jnci/46.2.iii

Cited by 179T-cell and Retrovirus StudiesChromosomal and Genetic VariationsViral-associated cancers and disorders

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The Protovirus Hypothesis: Speculations on the Significance of RNA-Directed DNA Synthesis for Normal Development and for Carcinogenesis

Howard M. Temin·1971·JNCI: Journal of the National Cancer Institute

DOI 10.1093/jnci/46.2.iii

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Howard M. Temin; The Protovirus Hypothesis: Speculations on the Significance of RNA-Directed DNA Synthesis for Normal Development and for Carcinogenesis, JNCI:

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Initially, reverse transcriptase was considered to be a viral enzyme unique to retroviruses and pararetroviruses (e.g., hepadnaviruses).
“Initially, RT was considered to be a viral enzyme unique to retroviruses and pararetroviruses (e.g., hepadnaviruses)”
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Authors: Temin, H. M.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Howard M. Temin
Venue: JNCI: Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 1971-02
Volume: 46
Issue: 2
Pages: 3-7
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/46.2.iii
OpenAlex: W1228757212
Cited by: 179
References: 0
Citations by year: 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
FWCI: 6.66
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: RNA-directed DNA synthesis, reverse transcription, carcinogenesis, typical development, oncogenes, retroviruses
MeSH terms: Cell Transformation, Neoplastic, DNA, DNA Nucleotidyltransferases, Genetic Code, Humans, Models, Biological, Mutation, RNA, Viral

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The Protovirus Hypothesis: Speculations on the Significance of RNA-Directed DNA Synthesis for Normal Development and for Carcinogenesis

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