Cited by 238Oral microbiology and periodontitis researchOral Health Pathology and TreatmentSalivary Gland Disorders and Functions

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Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23

Tannenbaum, S.R., Sinskey, A.J., Weisman, M., Bishop, W.·1974·JNCI Journal of the National Cancer Institute

DOI 10.1093/jnci/53.1.79

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Abstract

Nitrite was consistently found in human saliva at levels of usually 6-10 ppm. The nitrite level did not seem to be strongly influenced by the composition of a meal, and in some individuals a narrow range of nitrite concentration was maintained for a long time. In agreement with earlier work, parotid ductal saliva was found to be free of nitrite, and a major route of nitrite formation was via microbial reduction of nitrate naturally present in saliva. Exploration of various parameters related to the reduction of nitrate to nitrite did not demonstrate a clear correlation between measurements on individuals and their level of salivary nitrite. The microorganisms responsible for nitrite formation were identified and quantified, and the relationships between nitrate consumption and nitrite formation explored. These complex relationships suggested that the tree nitrite in saliva represents the “spillover” of that formed in microbial cells.

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Crossref · 10.1093/jnci/53.1.79

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Authors: Tannenbaum, S. R., Sinskey, A. J., Weisman, M., & Bishop, W.
Affiliations: Massachusetts Institute of Technology (US)
ORCID: Tannenbaum, S.R.
Sinskey, A.J.
Venue: JNCI Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 1974-07
Volume: 53
Issue: 1
Pages: 75-784
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/53.1.79
OpenAlex: W2319869190
Cited by: 237
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
FWCI: 17.72
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Keywords: salivary nitrite, nitrosamine formation, nitrate reduction, salivary microorganisms, parotid saliva, dietary nitrate intake
MeSH terms: Corynebacterium, Diet, Fusobacterium, Humans, Lactates, Nitrates, Nitrites, Nitrosamines, Nocardia, Oxidation-Reduction, Parotid Gland, Pyruvates, Saliva, Staphylococcus, Veillonella

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Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23

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