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Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23
Abstract
Nitrite was consistently found in human saliva at levels of usually 6-10 ppm. The nitrite level did not seem to be strongly influenced by the composition of a meal, and in some individuals a narrow range of nitrite concentration was maintained for a long time. In agreement with earlier work, parotid ductal saliva was found to be free of nitrite, and a major route of nitrite formation was via microbial reduction of nitrate naturally present in saliva. Exploration of various parameters related to the reduction of nitrate to nitrite did not demonstrate a clear correlation between measurements on individuals and their level of salivary nitrite. The microorganisms responsible for nitrite formation were identified and quantified, and the relationships between nitrate consumption and nitrite formation explored. These complex relationships suggested that the tree nitrite in saliva represents the “spillover” of that formed in microbial cells.
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“Earlier studies reported the half-life of NO2- in blood to be approximately 110 seconds; however, it is now clear that the half life of exogenously administered nitrite can range between 20–30 minutes thus making it a readily available buffering metabolite to maintain NO bioavailability [52, 68, 69].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [52]
In the citing paper
“As such, nitrate dependent nitrite production is predominantly generated from the enterosalivary circulatory system delivery of nitrate to the oral cavity where it is reduced by commensal bacteria nitrate reductase activity present in the digestive system (Figure 2) [49–53].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [52]
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Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Nitric oxide signaling in health and disease
Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 881
Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence
Mirvish, S. S. (1975) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(75)90255-0 · Cited by 779
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
Physiological role for nitrate-reducing oral bacteria in blood pressure control
Kapil, V., Haydar, S. M. A., Pearl, V., Lundberg, J. O., Weitzberg, E., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.013 · Cited by 413
The effect of nitrate intake on nitrite formation in human saliva
Tannenbaum, S. R., Weisman, M., & Fett, D. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80006-5 · Cited by 381
Self-citationMetabolic Effects of Dietary Nitrate in Health and Disease
Lundberg, J. O., Carlström, M., & Weitzberg, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.007 · Cited by 374
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347
Novel Aspects of Dietary Nitrate and Human Health
Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324
Nonenzymatic Nitric Oxide Production in Humans
Weitzberg, E., & Lundberg, J. O. N. (1998) · Nitric Oxide · doi:10.1006/niox.1997.0162 · Cited by 296
Nitrite and nitrate are formed by endogenous synthesis in the human intestine
Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R. (1978) · Science · doi:10.1126/science.663630 · Cited by 284
Self-citationNitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260
“However, due to the commensal bacteria that reside within the human body it has been demonstrated that these bacteria can reduce nitrate, thereby supplying an alternative source of nitrite [30–33].”
BackgroundDiscovery of the nitric oxide signaling pathway and targets for drug development
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3228 · Cited by 260
Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
Björne, H., Petersson, J., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19019 · Cited by 246
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237
Determination of nitrate and nitrite at the parts per billion level by chemiluminescence
Cox, R. D. (1980) · Analytical Chemistry · doi:10.1021/ac50052a028 · Cited by 231
Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism
Somasundaram, V., Basudhar, D., Bharadwaj, G., No, J. H., Ridnour, L. A., Cheng, R. Y. S., Fujita, M., Thomas, D. D., Anderson, S. K., McVicar, D. W., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7527 · Cited by 217
“The biology of NO emerged out of two lines of research: one, through the cardiovascular effects of endothelium-derived relaxing factor (53, 77, 86, 119), and the second from studies on the role of NO in immune response to tumor and infections (58, 69, 96, 143, 144, 151).”
BackgroundWagner, D. A., Young, V. R., & Tannenbaum, S. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4518 · Cited by 205
Self-citationChemistry, Analysis, and Biological Roles ofS-Nitrosothiols
Anthony, A. R., & Rhodes, P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2129 · Cited by 182
Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders
Tse, J. K. Y. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00176 · Cited by 175
Ruddell, W. S. J., Bone, E., Hill, M. J., Blendis, L. M., & Walters, C. L. (1976) · The Lancet · doi:10.1016/s0140-6736(76)90962-4 · Cited by 172
The toxicology of nitrate, nitrite and n‐nitroso compounds
SWANN, P. F. (1975) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740261119 · Cited by 168
Toh, J. W. T., & Wilson, R. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176451 · Cited by 168
Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., et al. (1997) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/s0300-9629(97)00023-6 · Cited by 147
Antioxidants-Carcinogenic and Chemopreventive Properties
Ito, N., & Hirose, M. (1989) · Advances in cancer research · doi:10.1016/s0065-230x(08)60283-3 · Cited by 145
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
Bryan, N. S., Tribble, G., & Angelov, N. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0725-2 · Cited by 137
Burleigh, M. C., Liddle, L., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Butcher, J. P., Henriquez, F. L., Allen, J. D., & Easton, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.023 · Cited by 127
“In this pathway, NO3 is rapidly absorbed in the upper 60 gastrointestinal tract and enters the circulation [9] before it is subsequently concentrated in 61 the saliva [10], [11] and a proportion reduced to NO2 .”
BackgroundClinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 130
Genotoxic and carcinogenic risk to humans of drug–nitrite interaction products
Brambilla, G., & Martelli, A. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.09.003 · Cited by 127
Nadtochiy, S. M., & Redman, E. (2011) · Nutrition · doi:10.1016/j.nut.2010.12.006 · Cited by 125
“After being accumulated in the saliva, NO3 can be reduced to NO2 by several bacterial organisms including Staphylococcus epidermidis, Veillonella, Nocardia, and Staphylococcus aureus [24,25].”
BackgroundInorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
“Earlier studies reported the half-life of NO2- in blood to be approximately 110 seconds; however, it is now clear that the half life of exogenously administered nitrite can range between 20–30 minutes thus making it a readily available buffering metabolite to maintain NO bioavailability [52, 68, 69].”
BackgroundSalivary Biomarkers for Clinical Applications
Zhang, L., Xiao, H., & Wong, D. T. (2009) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256330 · Cited by 114
“It was found that salivary nitrate levels parallel blood nitrate levels, which in turn were related to nitrate intake.([6]) This elicited much interest because nitrate was known to be converted by oral bacteria into nitrite, which in turn could be converted to nitroamines in the stomach.”
BackgroundNaturally Occurring Anticarcinogenic Substances in Foodstuffs
Fiala, E. S., Reddy, B. S., & Weisburger, J. H. (1985) · Annual Review of Nutrition · doi:10.1146/annurev.nu.05.070185.001455 · Cited by 116
Nitrate Ingestion: A Review of the Health and Physical Performance Effects
Clements, W., Lee, S.-R., & Bloomer, R. J. (2014) · Nutrients · doi:10.3390/nu6115224 · Cited by 118
“Historically, NO3− and NO2− have also been considered to be toxic to humans by causing the formation of N-nitrosamines [68], which are potential carcinogens [81–83].”
BackgroundComposition and safety of cured meats in the USA
CASSENS, R. G. (1997) · Food Chemistry · doi:10.1016/s0308-8146(97)00007-1 · Cited by 112
“Of great interest is the fact that a portion of the nitrate in the circulatory system is secreted by the salivary glands in humans but not in rats (Tannenbaum et al., 1974).”
BackgroundMirvish, S. S. (1977) · Journal of Toxicology and Environmental Health · doi:10.1080/15287397709529529 · Cited by 105
Nitrate-reducing bacteria on rat tongues
Li, H., Duncan, C., Townend, J., Killham, K., Smith, L. M., Johnston, P., Dykhuizen, R., Kelly, D., Golden, M., Benjamin, N., et al. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.3.924-930.1997 · Cited by 103
“However, saliva collected at other locations in the oral cavity also contains nitrite (9, 16, 20).”
BackgroundInfluentialShephard, S. E., Schlatter, C., & Lutz, W. K. (1987) · Food and Chemical Toxicology · doi:10.1016/0278-6915(87)90311-5 · Cited by 101
Bioavailability of sodium nitrite from an aqueous solution in healthy adults
Hunault, C. C., van Velzen, A. G., Sips, A. J. A. M., Schothorst, R. C., & Meulenbelt, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.06.865 · Cited by 102
The role of yeasts in oral cancer by means of endogenous nitrosation
Krogh, P. (1990) · Acta Odontologica Scandinavica · doi:10.3109/00016359009012738 · Cited by 99
Scanlan, R. A., & Issenberg, P. (1975) · C R C Critical Reviews in Food Technology · doi:10.1080/10408397509527180 · Cited by 100
Mechanisms of Chemical Carcinogenesis
Weisburger, E. K. (1978) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.18.040178.002143 · Cited by 92
Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology
Hartman, P. E. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6625-0_6 · Cited by 86
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 87
“This pathway involves active uptake of circulating nitrate in the salivary glands and excretion in saliva,(16) followed by reduction to nitrite by oral commensal bacteria.(17) After swallowing and uptake of nitrite in the gut, several enzymatic and non-enzymatic pathways exist in blood and tissues that reduce nitrite…”
BackgroundPereira, J. F. S., da Rocha, R. G., Castro, S. V. F., João, A. F., Borges, P. H. S., Rocha, D. P., de Siervo, A., Richter, E. M., Nossol, E., Gelamo, R. V., et al. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130651 · Cited by 86
The estimation of nitrate and nitrite in saliva and urine
Phizackerley, P. J. R., & Al-Dabbagh, S. A. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90161-6 · Cited by 83
Kolonel, L. N., Nomura, A. M., Hirohata, T., Hankin, J. H., & Hinds, M. W. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.11.2478 · Cited by 82
Ferreira, F. T. S. M., Mesquita, R. B. R., & Rangel, A. O. S. S. (2020) · Talanta · doi:10.1016/j.talanta.2020.121183 · Cited by 81
Tesch, J., Rehg, W. R., & Sievers, R. E. (1976) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)84117-0 · Cited by 78
Nitric oxide synthesis is decreased in periodontitis
Aurer, A., Aleksić, J., Ivić‐Kardum, M., Aurer-Kozelj, J., & Čulo, F. (2001) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2001.028006565.x · Cited by 74
Current Diagnostic Uses of Saliva
Ferguson, D. B. (1987) · Journal of Dental Research · doi:10.1177/00220345870660020601 · Cited by 73
Björne, H., Weitzberg, E., & Lundberg, J. O. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.020 · Cited by 67
“During the past few decades, major concerns have been raised concerning the potential formation of carcinogenic Nnitrosamines from nitrite and secondary amines in the stomach in connection with a high intake of nitrate [34].”
BackgroundRaubenheimer, K., Bondonno, C. P., Blekkenhorst, L. C., Wagner, K., Peake, J. M., & Neubauer, O. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz025 · Cited by 63
Jensen, O. M. (1982) · Ecotoxicology and Environmental Safety · doi:10.1016/0147-6513(82)90016-1 · Cited by 64
Nitro containing L-arginine analogs interfere with assays for nitrate and nitrite
Greenberg, S. S., Xie, J., Spitzer, J. J., Wang, J., Lancaster, J. R., Grisham, M. B., Powers, D. R., & Giles, T. D. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02181-h · Cited by 58
Methylation of DNA by nitrosocimetidine in vitro.
Jensen, D. E., & MAGEE, P. N. (1981) · PubMed · Cited by 54
Microbiota, diet and the generation of reactive nitrogen compounds
Carlström, M., Moretti, C. H., Weitzberg, E., & Lundberg, J. O. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.025 · Cited by 51
CASSENS, R. G., Ito, T., Lee, M., & Buege, D. R. (1978) · BioScience · doi:10.2307/1307393 · Cited by 52
Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours
McKean‐Cowdin, R., Pogoda, J. M., Lijinsky, W., Holly, E. A., Mueller, B. A., & Preston‐Martin, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg050 · Cited by 50
The biochemistry of nitrates, nitrites, nitrosamines and other potential carcinogens in human saliva
Tenovuo, J. O. (1986) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1986.tb00630.x · Cited by 51
Kiang, C.-H., Kuan, S. S., & Guilbault, G. G. (1978) · Analytical Chemistry · doi:10.1021/ac50031a031 · Cited by 48
Environmental N-nitroso compounds: Implications for public health
Wogan, G. N., & Tannenbaum, S. R. (1975) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(75)90259-8 · Cited by 47
Self-citationBayındır, Y. Z., Polat, M., & Seven, N. (2005) · Caries Research · doi:10.1159/000083158 · Cited by 45
“Nitrate-to-nitrite reduction is most probably brought about by the oral microbiota in the human mouth [Tannenbaum et al., 1974].”
BackgroundAntioxidant Activities of Medicinal Plant Extracts
Joo, S.-Y. (2013) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2013.42.4.512 · Cited by 45
Inhibition of Nitrosamine Formation by Ascorbic Acida
Tannenbaum, S. R., & Wishnok, J. S. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23774.x · Cited by 45
Self-citationRole of Nitrogen Dioxide in the Biosynthesis of Nitrosamines in Mice
Iqbal, Z. M., Dahl, K. D., & Epstein, S. S. (1980) · Science · doi:10.1126/science.7361099 · Cited by 45
Scragg, R. K. R., McMichael, A. J., Baghurst, P., & Dorsch, M. M. (1982) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1982.tb132578.x · Cited by 44
Yoshida, Y., Hirose, M., Takaba, K., Kimura, J., & Pito, N. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560122 · Cited by 43
Maas, R., Xanthakis, V., Göen, T., Müller, J., Schwedhelm, E., Böger, R. H., & Vasan, R. S. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006224 · Cited by 43
“Nitrate metabolism by the oral and gastrointestinal microbiome also has to be considered.(8,27,33) In clinical studies, the major part of the oral and gastric microbial nitrate metabolism to nitrite, and possibly NO, was observed shortly after ingestion.”
BackgroundS-Nitroso-N-acetylcysteine Generates Less Carcinogenic N-Nitrosamines in Meat Products than Nitrite
Shpaizer, A., Nussinovich, A., Kanner, J., & Tirosh, O. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04549 · Cited by 40
N-NITROSO COMPOUNDS, NITRITE, AND NITRATE: POSSIBLE IMPLICATIONS FOR THE CAUSATION OF HUMAN CANCER
Mirvish, S. S. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4832-1344-6.50018-6 · Cited by 43
Destruction of parotid glands affects nitrate and nitrite metabolism
Xia, D. S., Deng, D. J., & Wang, S. L. (2003) · Journal of Dental Research · doi:10.1177/154405910308200205 · Cited by 42
“Saliva collected directly from either parotid or submandibular salivary ducts contains nitrate but no nitrite, while mixed whole saliva contains both (Tannenbaum et al., 1974; Ishiwata et al., 1975a).”
BackgroundN-Nitrosamines: A Review of Chemical and Biological Properties and Their Estimation in Foodstuffs
Crosby, N. T., & Sawyer, R. (1976) · Advances in food research · doi:10.1016/s0065-2628(08)60336-5 · Cited by 43
Some biochemical aspects of N-nitroso compounds
Digenis, G. A., & ISSIDORIDES, C. H. (1979) · Bioorganic Chemistry · doi:10.1016/0045-2068(79)90041-5 · Cited by 41
On the aetiology of gastric cancer: Mutagenicity of food extracts after incubation with nitrite
Marquardt, H. W. J., Rufino, F., & Weisburger, J. H. (1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80312-x · Cited by 41
Determination of nitrite ion using differential pulse polarography
Chang, S.-K., Kozeniauskas, R., & Harrington, G. W. (1977) · Analytical Chemistry · doi:10.1021/ac50022a041 · Cited by 41
Excretion of nitrates and nitrites in saliva and bile in the dog
Fritsch, P., Blanquat, G. D. S., & Klein, D. (1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90153-x · Cited by 37
Nitrates in the human diet - good or bad?
Benjamin, N. (2000) · Annales de Zootechnie · doi:10.1051/animres:2000118 · Cited by 39
Nitrite and thiocyanate in the fasting and secreting stomach and in saliva.
Ruddell, W. S., Blendis, L. M., & Walters, C. L. (1977) · Gut · doi:10.1136/gut.18.1.73 · Cited by 37
“However, nitiite is undoubtedly present in saliva, presumably as a result of bacterial reduction of nitrate, as pure parotid duct saliva is free of nitrite (Tannenbaum et al., 1974).”
BackgroundFourier Transform infrared analysis below the one-nanogram level
Cournoyer, R., Shearer, J. C., & Anderson, D. H. (1977) · Analytical Chemistry · doi:10.1021/ac50022a042 · Cited by 37
Xia, D., Deng, D., & Wang, S. (2003) · Journal of Oral Pathology & Medicine · doi:10.1034/j.1600-0714.2003.00109.x · Cited by 36
Antimicrobial effect of acidified nitrate and nitrite on six common oral pathogens in vitro
Xia, D., Liu, Y., Zhang, C., Sheng-hui, Y., & Wang, S. (2006) · Chinese Medical Journal · doi:10.1097/00029330-200611020-00010 · Cited by 39
Sen, N. P., Seaman, S. W., Baddoo, P. A., Burgess, C., & Weber, D. F. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0011384 · Cited by 36
Pharmacokinetic Aspects of Inorganic Nitrate Ingestion in Man
Cortas, N. K., & Wakid, N. W. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01221.x · Cited by 36
Sen, N. P., Baddoo, P. A., & Seaman, S. W. (1994) · Journal of Chromatography A · doi:10.1016/0021-9673(94)87059-4 · Cited by 36
Tatemichi, M., Ogura, T., Nagata, H., & Esumi, H. (1998) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199810000-00012 · Cited by 35
Cardioprotective actions of nitrite therapy and dietary considerations
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3568 · Cited by 34
Carcinogenic and Mutagenic N-Nitroso Compounds
Lijinsky, W. (1976) · Springer eBooks · doi:10.1007/978-1-4684-0892-8_7 · Cited by 34
Kawabe, M., Takaba, K., Yoshida, Y., & Hirose, M. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02881.x · Cited by 32
THE INDUCTION OF LIVER CELL CANCER BY CHEMICALS
Wogan, G. N. (1976) · Elsevier eBooks · doi:10.1016/b978-0-444-41542-4.50011-0 · Cited by 32
Lin, J., Lee, Y.-J., & Chang, H. W. (1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90228-4 · Cited by 31
Ascorbic Acid Inhibition of N-Nitroso Compound Formation in Chemical, Food, and Biological Systems
Mirvish, S. S. (1981) · Springer eBooks · doi:10.1007/978-1-4615-9218-1_4 · Cited by 30
Türkdoğan, M. K., Testereci, H., Akman, N., Kahraman, T., Kara, K., Tuncer, İ., & Uygan, İ. (2003) · The Turkish Journal of Gastroenterology · Cited by 29
Hazards of Nitrate, Nitrite, and N-Nitroso Compounds in Human Nutrition
Archer, M. C. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-332601-0.50014-0 · Cited by 29
Food Polyphenols as Preventive Medicine
Kanner, J. (2023) · Antioxidants · doi:10.3390/antiox12122103 · Cited by 31
“In stomach nitrite can react with secondary amines at the low pH of gastric fluid to form nitrosamines [53].”
Background
Metadata
- Authors
- Tannenbaum, S. R., Sinskey, A. J., Weisman, M., & Bishop, W.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-07
- Volume
- 53
- Issue
- 1
- Pages
- 75-784
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2319869190
- Cited by
- 237
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
- Keywords
- salivary nitrite, nitrosamine formation, nitrate reduction, salivary microorganisms, parotid saliva, dietary nitrate intake
- MeSH terms
- Corynebacterium, Diet, Fusobacterium, Humans, Lactates, Nitrates, Nitrites, Nitrosamines, Nocardia, Oxidation-Reduction, Parotid Gland, Pyruvates, Saliva, Staphylococcus, Veillonella
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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