Cited by 114Telomeres, Telomerase, and SenescenceCancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.

Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells

Cuthbert, A. P., Bond, J., Trott, D. A., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, E. K., Cooper, C. S., Newbold, R. F.·1999·JNCI Journal of the National Cancer Institute

DOI 10.1093/jnci/91.1.37

Open this paper in CoChat — free account

Abstract

BACKGROUND: Activation of the enzyme telomerase, which has been associated with cellular immortality, may constitute a key step in the development of human cancer. Telomerase is repressed in most normal human somatic cells. This study was conducted, using a genetic complementation approach, with the aim of identifying and mapping the genes responsible for repressing telomerase and, simultaneously, to establish the effect of experimentally induced telomerase repression on human tumor cell growth. METHODS: Individual human chromosomes isolated from normal diploid cells and tagged with bacterial antibiotic resistance genes (for later selection) were introduced into cells of the human breast carcinoma cell line 21NT by means of microcell transfer. Selected hybrid clones were screened for telomerase activity by use of the polymerase chain reaction-based telomere repeat amplification protocol (TRAP) assay, and the proliferative fate of the hybrid clones was determined. Regions of the introduced chromosomes associated with telomerase repression were mapped using segregant hybrids and a deletion analysis that employed microsatellite DNA markers. RESULTS: Strong repression of telomerase was observed following transfer of human chromosome 3 into 21NT cells but not after transfer of chromosomes 8, 12, or 20. The vast majority of hybrid clones with repressed telomerase entered permanent growth arrest after 10-18 population doublings. Deletion analysis of nonrepressed segregant monochromosome 3 hybrids indicated two regions on the short arm of chromosome 3 (3p21.3-p22 and 3p12-21.1) where telomerase regulator genes may be located. CONCLUSIONS: Telomerase in human breast cancer cells is efficiently repressed by a gene or genes on normal human chromosome 3p, and this repression is associated with permanent growth arrest of the tumor cells.

Integrity signals

Registry

Crossref · 10.1093/jnci/91.1.37

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 2×
“Recent comparisons of the activity of the enzyme telomerase in normal and immortal human cells have led to the formulation of an attractive molecular model to explain replicative cellular senescence and immortalization ( 9 ).”
Background
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
A comprehensive genetic map of the human genome based on 5,264 microsatellites
Dib, C., Fauré, S., Fizames, C., Samson, D. S., Drouot, N., Alain Vignal, A., Millasseau, P., Marc, S., Kazan, J., Seboun, E., et al. (1996) · Nature · doi:10.1038/380152a0 · Cited by 2,927
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096

Show all 59 references

Research works printed but not linked: 8

Rheinwald, 1981, Cancer Research, 41, 1657
Band, 1990, Cancer Research, 50, 7351
1993, International journal of oncology, 3, 559
Boukamp, 1990, Cancer Research, 50, 2840
Yamakawa, 1993, Oncogene, 8, 327
Roche, 1996, Oncogene, 12, 1289
Todd, 1996, Oncogene, 13, 2387
1995, International journal of oncology, 6, 369

Sorted by citations

Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898
Profiling early head and neck cancer
Hunter, K. D., Parkinson, E. K., & Harrison, P. R. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1549 · Cited by 436
Self-citation
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
Wistuba, I. I., Behrens, C., Virmani, A. K., Mele, G. M., Milchgrub, S., Girard, L., Fondon, J. W., Garner, H. R., McKay, B., Latif, F., et al. (2000) · PubMed · Cited by 405
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
Kyo, S., Takakura, M., Fujiwara, T., & Inoue, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00878.x · Cited by 347
A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity
Gowan, S. M., Harrison, J. R., Patterson, L., Valenti, M. R., Read, M. A., Neidle, S., & Kèlland, L. R. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.5.1154 · Cited by 313
Studies of the molecular mechanisms in the regulation of telomerase activity
Liu, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2091 · Cited by 254
Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
Russo, J., Lareef, M. H., Balogh, G., Guo, S., & Russo, I. H. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00390-x · Cited by 252
Potent Inhibition of Telomerase by Small-Molecule Pentacyclic Acridines Capable of Interacting with G-Quadruplexes
Gowan, S. M., Heald, R. A., Stevens, M. F. G., & Kèlland, L. R. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.5.981 · Cited by 236
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer
Osada, H., & Takahashi, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205802 · Cited by 220
Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells
O’Hare, M. J., Bond, J., Clarke, C., Takeuchi, Y., Atherton, A. J., Berry, C. O. A., Moody, J. C., Silver, A. R., Davies, D. C., Alsop, A. E., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.646 · Cited by 219
Self-citation
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
Horikawa, I., & Barrett, J. C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg085 · Cited by 207
Regulation of the human telomerase reverse transcriptase gene
Ducrest, A., Szutorisz, H., Lingner, J., & Nabholz, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205081 · Cited by 184
Differential effect of adenosine on tumor and normal cell growth: Focus on the A3 adenosine receptor
Ohana, G., Bar‐Yehuda, S., Barer, F., & Fishman, P. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200101)186:1 · Cited by 123
Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?
Kyo, S., & Inoue, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205163 · Cited by 180
Identification of Mad as a repressor of the human telomerase (hTERT) gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161
The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37473 · Cited by 148
Telomeres and Telomerase in Aging, Regeneration and Cancer
Djojosubroto, M. W., Choi, Y. S., Lee, H., & Rudolph, K. L. (2003) · Molecules and Cells · doi:10.1016/s1016-8478(23)13723-x · Cited by 146
Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis
Masuda, A., & Takahashi, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205566 · Cited by 133
The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.
Saloman, D. S., Bianco, C., Ebert, A. D., Khan, N. I., Santis, M. D., Normanno, N., Wechselberger, C., Seno, M., Williams, K. P., Sanicola, M., et al. (2000) · Endocrine Related Cancer · doi:10.1677/erc.0.0070199 · Cited by 126
The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
Sarakbi, W. A., Sasi, W., Jiang, W. G., Roberts, T., Newbold, R. F., & Mokbel, K. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-290 · Cited by 120
Self-citation
Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival
Wu, K., Orme, L. M., Shaughnessy, J. D., Jacobson, J. L., Barlogie, B., & Moore, M. A. S. (2003) · Blood · doi:10.1182/blood-2002-11-3451 · Cited by 113
Role of Telomerase in Cell Senescence and Oncogenesis
Urquidi, V., Tarin, D., & Goodison, S. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.65 · Cited by 110
The significance of telomerase activation and cellular immortalization in human cancer
Newbold, R. F. (2002) · Mutagenesis · doi:10.1093/mutage/17.6.539 · Cited by 94
Self-citation
Combined karyotyping, CGH and M‐FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma
Gele, M. V., Leonard, J. H., Roy, N. V., Limbergen, H. V., Belle, S. V., Cocquyt, V., Salwen, H. R., Paepe, A. D., & Speleman, F. (2002) · International Journal of Cancer · doi:10.1002/ijc.10591 · Cited by 88
Downstream E-Box–mediated Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene Transcription: Evidence for an Endogenous Mechanism of Transcriptional Repression
Horikawa, I., Cable, P. L., Mazur, S. J., Appella, E., Afshari, C. A., & Barrett, J. C. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e01-11-0107 · Cited by 88
Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.
Ducrest, A., Amacker, M., Mathieu, Y., Cuthbert, A. P., Trott, D. A., Newbold, R. F., Nabholz, M., & Lingner, J. (2001) · PubMed · Cited by 85
Self-citation
Telomerase regulation at the crossroads of cell fate
Ćukušić, A., Vidaček, N. Š., Sopta, M., & Rubelj, I. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167812 · Cited by 80
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma
Xiang, W., He, J., Huang, C., Chen, L., Tao, D., Wu, X., Wang, M., Luo, G., Xiao, X., Zeng, F., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.2926 · Cited by 77
Identification of PITX1 as a TERT Suppressor Gene Located on Human Chromosome 5
Qi, D.-L., Ohira, T., Fujisaki, C., Inoue, T., Ohta, T., Osaki, M., Ohshiro, E., Seko, T., Aoki, S., Oshimura, M., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00470-10 · Cited by 70
Telomerase Suppression by Chromosome 6 in a Human Papillomavirus Type 16-Immortalized Keratinocyte Cell Line and in a Cervical Cancer Cell Line
Steenbergen, R. D. M., Kramer, D., Meijer, C. J. L. M., Walboomers, J. M. M., Trott, D. A., Cuthbert, A. P., Newbold, R. F., Overkamp, W. J. I., Zdzienicka, M. Z., & Snijders, P. J. F. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.11.865 · Cited by 68
Self-citation
Telomere and telomerase in oncology
Mu, J., & Li Xin, W. E. I. (2002) · Cell Research · doi:10.1038/sj.cr.7290104 · Cited by 63
Genetics of cellular senescence
Tominaga, K., Olgun, A., Smith, J. R., & Pereira‐Smith, O. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00030-1 · Cited by 55
Molecular regulation of telomerase activity in aging
Nicholls, C., Li, H., Wang, J.-Q., & Liu, J. (2011) · Protein & Cell · doi:10.1007/s13238-011-1093-3 · Cited by 57
Functional evidence for a telomerase repressor gene on human chromosome 10p15.1
Nishimoto, A., Miura, N., Horikawa, I., Kugoh, H., Murakami, Y., Hirohashi, S., Kawasaki, H., Gazdar, A. F., Shay, J. W., Barrett, J. C., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204165 · Cited by 53
Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.
Newbold, R. F., & Mokbel, K. (2010) · PubMed · Cited by 50
Self-citation
Telomere length maintenance in aging and carcinogenesis.
Aragona, M., Maisano, R., Panetta, S., Giudice, A., Morelli, M., Torre, I. L., & Torre, F. L. (2000) · International Journal of Oncology · doi:10.3892/ijo.17.5.981 · Cited by 51
Effects of Chemopreventive and Antitelomerase Agents on the Spontaneous Immortalization of Breast Epithelial Cells
Herbert, B., Wright, A., Passons, C., Wright, W. E., Ali, I., Kopelovich, L., & Shay, J. W. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.1.39 · Cited by 51
Telomerase and cancer: time to move from a promising target to a clinical reality
Keith, W. N., Evans, T. R. J., & Glasspool, R. M. (2001) · The Journal of Pathology · doi:10.1002/path.1001 · Cited by 47
Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4Preprint
Liddiard, K., Ruis, B. L., Takasugi, T., Harvey, A., Ashelford, K. E., Hendrickson, E. A., & Baird, D. M. (2016) · Genome Research · doi:10.1101/gr.200840.115 · Cited by 48
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression.
Werner, N. S., Siprashvili, Z., Fong, L. Y. Y., Marquitan, G., Schröder, J., Bardenheuer, W., Seeber, S., Huebner, K., Schütte, J., & Opalka, B. (2000) · PubMed · Cited by 45
Transfer of chromosome 3 fragments suppresses tumorigenicity of an ovarian cancer cell line monoallelic for chromosome 3p
Cody, N. A. L., Ouellet, V., Manderson, E. N., Quinn, M. C. J., Filali-Mouhim, A., Tellis, P. A., Zietarska, M., Provencher, D. M., Mes‐Masson, A., Chevrette, M., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209821 · Cited by 44
The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer
Meaburn, K. J., Parris, C. N., & Bridger, J. M. (2005) · Chromosoma · doi:10.1007/s00412-005-0014-8 · Cited by 42
Recent advances in the development of telomerase inhibitors for the treatment of cancer
Perry, P. J., & Jenkins, T. C. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.12.1981 · Cited by 42
Identification of a Novel Transcription Factor Binding Element Involved in the Regulation by Differentiation of the Human Telomerase (hTERT) Promoter
Tzukerman, M., Shachaf, C. M., Ravel, Y., Braunstein, I., Cohen‐Barak, O., Yalon-Hacohen, M., & Skorecki, K. L. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4381 · Cited by 41
Telomerase inhibitors: targeting the vulnerable end of cancer?
Kèlland, L. R. (2000) · Anti-Cancer Drugs · doi:10.1097/00001813-200008000-00001 · Cited by 40
Telomerase inhibition and the future management of head-and-neck cancer
McCaul, J. A., Gordon, K., Clark, L., & Parkinson, E. K. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00729-5 · Cited by 39
Self-citation
Toward Identifying a Cellular Determinant of Telomerase Repression
Shay, J. W. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.4 · Cited by 39
Methodologies in cancer cytogenetics and molecular cytogenetics
Wang, N. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10687 · Cited by 36
Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation
Krupp, G., Klapper, W., & Parwaresch, R. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000708 · Cited by 36
Specificity of PCR-based clonality analysis of immunoglobulin heavy chain gene rearrangements for the detection of bone marrow involvement by low-grade B-cell lymphomas
Brinckmann, R., Kaufmann, O., Reinartz, B., & Dietel, M. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200001)190:1 · Cited by 21
Carcinogenicity of estrogens in human breast epithelial cells1
Russo, J., Hu, Y. F., Tahin, Q. S., Mihaila, D., Slater, C. M., Lareef, M. H., & Russo, I. H. (2001) · Apmis · doi:10.1111/j.1600-0463.2001.tb00013.x · Cited by 35
Cytogenetic studies of esophageal squamous cell carcinomas in the northern Chinese population by comparative genomic hybridization
Wei, F., Ni, J. Y., Wu, S., Liu, H., Xu, X., Han, Y., Cai, Y., Zhang, J., Chen, X., Pang, H., et al. (2002) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(02)00586-1 · Cited by 30
Downregulation of nitrogen permease regulator like‐2 activates PDK1‐AKT1 and contributes to the malignant growth of glioma cells
Huang, N., Cheng, S., Mi, X., Tian, Q., Huang, Q., Wang, F., Xu, Z., Xie, Z., Chen, J., & Cheng, Y. Z. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22413 · Cited by 28
Targeting the genetic landscape of oral potentially malignant disorders has the potential as a preventative strategy in oral cancer
Prime, S. S., Cirillo, N., Cheong, S. C., Prime, M. S., & Parkinson, E. K. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.025 · Cited by 29
Self-citation
Telomerase Activation in Human Hepatocarcinogenesis
Hytiroglou, P., & Theise, N. D. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00521.x · Cited by 26
Genetic approaches to the study of replicative senescence
Ran, Q. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00080-7 · Cited by 24
SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion
Chen, Z., Raghoonundun, C.-D., Chen, W., Zhang, Y., Tang, W., Fan, X., & Shi, X. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.022 · Cited by 26
Senescence as a modulator of oral squamous cell carcinoma development
Parkinson, E. K. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2009.09.009 · Cited by 23
Self-citation
Induction of apoptosis in lung-cancer cells followingbcl-xL anti-sense treatment
Leech, S. H., Olie, R. A., Gautschi, O. P., Sim�es-W�st, A. P., Tschopp, S., H�ner, R., Hall, J., Stahel, R. A., & Zangemeister‐Wittke, U. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000515)86:4 · Cited by 98
A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin.
Szutorisz, H., Lingner, J., Cuthbert, A. P., Trott, D. A., Newbold, R. F., & Nabholz, M. (2003) · PubMed · Cited by 21
Self-citation
Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers
Sandomenico, A., & Ruvo, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180912104707 · Cited by 20
Complex Regulation of Telomerase Activity
Elenitoba‐Johnson, K. S. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61710-5 · Cited by 20
True
Chang, J. T.-C., Liao, C.-T., Jung, S.-M., Wang, T.-C. V., See, L.-C., & Cheng, A.-J. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1194 · Cited by 20
Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas
Szutorisz, H., Palmqvist, R., Roos, G., Stenling, R., Schorderet, D. F., Reddel, R. R., Lingner, J., & Nabholz, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204346 · Cited by 18
Prevention of breast cancer
Carolin, K. A., & Pass, H. A. (2000) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(99)00076-1 · Cited by 19
Identification and Validation of Tumor Suppressor Genes
Robertson, G. P., Huang, H., & Cavenee, W. K. (1999) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.1999.0141 · Cited by 18
Novel Tumor Suppressor Locus in Human Chromosome Region 3p14.2
Jülicher, K., Marquitan, G., Werner, N. S., Bardenheuer, W., Vieten, L., Bröcker, F., Topal, H., Seeber, S., Opalka, B., & Schütte, J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.18.1563 · Cited by 18
Cancer treatment by telomerase inhibitors: predictions by a kinetic model
Sidorov, I. A., Hirsch, K. S., Harley, C. B., & Dimitrov, D. S. (2003) · Mathematical Biosciences · doi:10.1016/s0025-5564(02)00132-3 · Cited by 17
Telomerase activity in high‐grade cervical lesions is associated with allelic imbalance at 6Q14–22
van Duin, M., Steenbergen, R. D. M., de Wilde, J., Helmerhorst, T. J. M., Verheijen, R. H. M., Risse, E. K. J., Meijer, C. J. L. M., & Snijders, P. J. F. (2003) · International Journal of Cancer · doi:10.1002/ijc.11145 · Cited by 17
Resistance to apoptosis in human cells conferred by telomerase function and telomere stability
Holt, S. E., Glinsky, V. V., Ivanova, A. B., & Glinsky, G. V. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199908)25:4 · Cited by 118
Chromosomal and telomeric reprogramming following ES-somatic cell fusion
Sümer, H., Nicholls, C., Pinto, A. R., Indraharan, D., Liu, J., Lim, M. L., Liu, J., & Verma, P. J. (2009) · Chromosoma · doi:10.1007/s00412-009-0245-1 · Cited by 16
Telomerase and oral cancer
Sumida, T., & Hamakawa, H. (2001) · Oral Oncology · doi:10.1016/s1368-8375(00)00132-9 · Cited by 15
Telomerase as a new target for pancreatic cancer treatment
Sato, N., Mizumoto, K., Nagai, E., & Tanaka, M. (2002) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340200036 · Cited by 15
Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells
Horikawa, I., Parker, E. S., Solomon, G. G., & Barrett, J. C. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1169 · Cited by 14
Allelic loss of chromosome 3p24 correlates with tumor progression rather than with retinoic acid receptor β2 expression in breast carcinoma
Yang, Q., Yoshimura, G., Sakurai, T., Nakamura, M., Nakamura, Y., Shan, L., Suzuma, T., Tamaki, T., Umemura, T., Mori, I., et al. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1012574305832 · Cited by 14
Functional role of SETD2, BAP1, PARP-3 and PBRM1 candidate genes on the regulation of hTERT gene expression
Linne, H., Yasaei, H., Marriott, A., Harvey, A., Mokbel, K., Newbold, R. F., & Roberts, T. (2017) · Oncotarget · doi:10.18632/oncotarget.18712 · Cited by 14
Self-citation
The Role of Estrogen in Breast Cancer
Russo, J., & Russo, I. H. (2004) · Springer eBooks · doi:10.1007/978-3-642-18736-0_4 · Cited by 13
Absence of telomerase activity and telomerase catalytic subunit mRNA in melanocyte cultures
Dhaene, K., Vancoillie, G., Lambert, J., Naeyaert, J. M., & Marck, E. V. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.1041 · Cited by 13
Cellular Senescence of a Human Bladder Carcinoma Cell Line (JTC-32) Induced by a Normal Chromosome 11
Kugoh, H., Fujiwara, M., Kihara, K., Fukui, I., Horikawa, I., Schulz, T. C., & Oshimura, M. (2000) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(99)00138-7 · Cited by 11
Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications
Iniesta, P., Gonzalez‐Quevedo, R., Morán, A., García-Aranda, C., de Juan, C., Sánchez-Pernaute, A., Torres, A., Díaz‐Rubio, E., Balibrea, J. L., & Benito, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601775 · Cited by 9
Cancer Cell Dynamics in Presence of Telomerase Inhibitors: Analysis of In Vitro Data
Sidorov, I. A., Hirsch, K. S., Harley, C. B., & Dimitrov, D. S. (2002) · Journal of Theoretical Biology · doi:10.1006/jtbi.2002.3117 · Cited by 9
Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers
Tanaka, H., Horikawa, I., Barrett, J. C., & Oshimura, M. (2005) · International Journal of Cancer · doi:10.1002/ijc.20879 · Cited by 9
Cellular Senescence Mechanisms Independent of Telomere Shortening and Telomerase: Other Barriers to Cell Immortalization and Carcinogenesis
Horikawa, I., Yawata, T., & Barrett, J. C. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.373 · Cited by 9
hTR repressor-related gene on human chromosome 10p15.1
Miura, N., Onuki, N., Rathi, A., Virmani, A. K., Nakamoto, S., Kishimoto, Y., Murawaki, Y., Kawasaki, H., Hasegawa, J., Oshimura, M., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2121 · Cited by 9
Transfer of chromosome 8 into two breast cancer cell lines
Wilson, P. J., Cuthbert, A. P., Marsh, A. J., Arnold, J. M., Flanagan, J. M., Mulford, C., Trott, D. A., Baker, E. G., Purdie, D. M., Newbold, R. F., et al. (2003) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(02)00850-6 · Cited by 9
Self-citation
Molecular mechanisms regulating telomerase activity
Liu, J. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08003-8 · Cited by 9
Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15
Fitzsimmons, S. A., Ireland, H., Barr, N. I., Cuthbert, A. P., Going, J. J., Newbold, R. F., & Parkinson, E. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206295 · Cited by 8
Self-citation
A Mortality Gene(s) for the Human Adenocarcinoma Line HeLa Maps to a 130-kb Region of Human Chromosome 4q22-q23
Bryce, S. D., Morrison, V., Craig, N. J., Forsyth, N. R., Fitzsimmons, S. A., Ireland, H., Cuthbert, A. P., Newbold, R. F., & Parkinson, E. K. (2002) · Neoplasia · doi:10.1038/sj.neo.7900268 · Cited by 8
Self-citation
Mandatory chromosomal segment balance in aneuploid tumor cells
Kost‐Alimova, M., Darai‐Ramqvist, E., Yau, W. L., Sandlund, A., Fedorova, L., Yang, Y., Kholodnyuk, I., Cheng, Y., Lung, M. L., Stanbridge, E. J., et al. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-21 · Cited by 7
Clinical applications of telomerase in cancer treatment
Faraoni, I., Bonmassar, E., & Graziani, G. (2000) · Drug Resistance Updates · doi:10.1054/drup.2000.0139 · Cited by 6
5-aza-2′-deoxycytidine induces telomere dysfunction in breast cancer cells
Al-dulaimi, S., Matta, S., Slijepčević, P., & Roberts, T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117173 · Cited by 5
Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13–24 as an early and common genetic event
Siwicki, J. K., Berglund, M., Rygier, J., Pieńkowska‐Grela, B., Grygalewicz, B., Degerman, S., Golovleva, I., Chrzańowska, K., Bajalica‐Lagercrantz, S., Blennow, E., et al. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20059 · Cited by 4
Preparation of Monoclonal Antibodies Against Human Telomerase
Kaur, H., Richardson, E. S., & Murty, L. C. (2001) · Hybridoma · doi:10.1089/027245701750293510 · Cited by 4
Carcinogenicity of estrogens in human breast epithelial cells1
Russo, J., Hu, Y. F., Tahin, Q. S., Mihaila, D., Slater, C. M., Lareef, M. H., & Russo, I. H. (2001) · Apmis · doi:10.1111/j.1600-0463.2001.tb05825.x · Cited by 4
Telomeres and Telomerase in Aging, Regeneration and Cancer
(2003) · Molecules and Cells · doi:10.1016/s1016-8478(23)13779-4 · Cited by 3
Expression of Recombinant Carcinoembryonic-Antigen-Human-β-Defensin-2 Gene in Colon Cancer HCT116 Cells
Zhang, Y., Du, J., & Chen, Z. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9730-5 · Cited by 2
Telomerase and Malignant Transformation
Yu, J., & Dubeau, L. (2002) · Springer eBooks · doi:10.1007/978-1-4757-3587-1_9 · Cited by 2
Telomeraseaktivität beim Bronchialkarzinom12 - Der Nachweis des „Unsterblichkeitsenzyms” in Bürstenbiopsien erhöht die diagnostische Ausbeute bei Verdacht auf ein peripheres Karzinom -
Freitag, L., Litterst, P., Obertrifter, B., Velehorschi, V., Kemmer, H. P., Linder, A., & Brightman, I. (2000) · Pneumologie · doi:10.1055/s-2000-8252 · Cited by 2
Stage as major long term outcome predictor in minor salivary gland carcinoma
Lutgendorf (2000) · Pure Amsterdam UMC · doi:10.1002/1097-0142(20000915)89:6 · Cited by 1
Biological Clocks in the Aging Cell
Boukamp, P. (2003) · Springer eBooks · doi:10.1007/978-94-017-0667-4_8 · Cited by 1

Authors: Cuthbert, A. P., Bond, J., Trott, D. A., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, E. K., Cooper, C. S., & Newbold, R. F.
Affiliations: Brunel University of London (GB)
Corresponding author: Cuthbert, A. P.
ORCID: Parkinson, E. K.
Cooper, C. S.
Venue: JNCI Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 1999-01-06
Volume: 91
Issue: 1
Pages: 37-45
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/91.1.37
OpenAlex: W2102936230
Cited by: 114
References: 59
Citations by year: 2024: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1
FWCI: 13.40
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
Brunel University Research Archive (BURA) (Brunel University London) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: telomerase, chromosome 3, breast cancer, growth arrest, gene complementation, chromosome 3p, telomere repeat amplification protocol
MeSH terms: Adult, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Cell Division, Cell Fusion, Chromosomes, Chromosomes, Human, Pair 3, Female, Growth Inhibitors, Humans, Hybrid Cells, Neoplasm Proteins, Repressor Proteins, Tumor Cells, Cultured, Gene Expression Regulation, Enzymologic, Polymerase Chain Reaction, Telomere, In Situ Hybridization, Fluorescence, Gene Transfer Techniques, Telomerase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks