The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works

A survey of telomerase activity in human cancer

Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794 · see citing works

Creation of human tumour cells with defined genetic elements

Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345 · see citing works

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784 · see citing works

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

Vaziri, H., & Benchimol, S. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70109-5 · Cited by 1,003 · see citing works

Direct activation of TERT transcription by c-MYC

Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893 · see citing works

Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types

Kilian, A., Bowtell, D. D. L., Abud, H. E., Hime, G. R., Venter, D. J., Keese, P., Duncan, E. L., Reddel, R. R., & Jefferson, R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.12.2011 · Cited by 586 · see citing works

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

Cong, Y. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.137 · Cited by 485 · see citing works

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

高倉, 正. (2002) · Medical Entomology and Zoology · Cited by 475 · see citing works

The telomerase reverse transcriptase: components and regulationPreprint

Nugent, C. I., & Lundblad, V. (1998) · Genes & Development · doi:10.1101/gad.12.8.1073 · Cited by 433 · see citing works

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

Greenberg, R. A., O’Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., & DePinho, R. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202669 · Cited by 411 · see citing works

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

Kim, T. K., & Maniatis, T. (1996) · Science · doi:10.1126/science.273.5282.1717 · Cited by 410 · see citing works

Telomerase activity, cell proliferation, and cancer

Greider, C. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.90 · Cited by 401 · see citing works

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

Horikawa, I., Cable, P. L., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 395 · see citing works

The Mechanism of Transcriptional Synergy of an In Vitro Assembled Interferon-β Enhanceosome

Kim, T. K., & Maniatis, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80013-1 · Cited by 340 · see citing works

Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

Sedivy, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9078 · Cited by 182 · see citing works

Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4.

Ning, Y., Weber, J. L., Killary, A. M., Ledbetter, D. H., Smith, J. R., & Pereira‐Smith, O. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5635 · Cited by 176 · see citing works

The role of WT1 in Wilms tumorigenesis

Coppes, M. J., Campbell, C. E., & Williams, B. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.10.8393819 · Cited by 153 · see citing works

Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour

Park, S., Bernard, A., Bove, K. E., Sens, D. A., Hazen‐Martin, D. J., Garvin, A. J., & Haber, D. A. (1993) · Nature Genetics · doi:10.1038/ng1293-363 · Cited by 143 · see citing works

Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3

Ohmura, H., Tahara, H., Suzuki, M., Ide, T., Shimizu, M., Yoshida, M. A., Tahara, E., Shay, J. W., Barrett, J. C., & Oshimura, M. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb02998.x · Cited by 123 · see citing works

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

Wright, W. E., & Shay, J. W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89044-3 · Cited by 121 · see citing works

Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells

Cuthbert, A. P., Bond, J., Trott, D. A., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, E. K., Cooper, C. S., & Newbold, R. F. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.37 · Cited by 114 · see citing works

Effects of activation-defective TBP mutations on transcription initiation in yeast

Kim, T. K., Hashimoto, S., Kelleher, R. J. I., Flanagan, P., Kornberg, R., Horikoshi, M., & Roeder, R. (1994) · Nature · doi:10.1038/369252a0 · Cited by 114 · see citing works

A Gene Involved in Control of Human Cellular Senescence on Human Chromosome 1q

Hensler, P. J., Annab, L. A., Barrett, J. C., & Pereira‐Smith, O. M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2291 · Cited by 95 · see citing works

Multiple pathways for the regulation of telomerase activity

Holt, S. E., Wright, W. E., & Shay, J. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00066-x · Cited by 94 · see citing works

Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome—proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development

Hastie, N. D. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.5.293 · Cited by 79 · see citing works

Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

Horikawa, I., Oshimura, M., & Barrett, J. C. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199806)22:2 · Cited by 78 · see citing works

In Vivo and in Vitro Analyses of Myc for Differential Promoter Activities of the Human Telomerase (hTERT) Gene in Normal and Tumor Cells

Oh, S., Song, Y., Kim, U.-J., Yim, J., & Kim, T. K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1366 · Cited by 71 · see citing works

Induction of Rb-associated Protein (RbAp46) by Wilms' Tumor Suppressor WT1 Mediates Growth Inhibition

Guan, L., Rauchman, M. I., & Wang, Z. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27047 · Cited by 61 · see citing works

WT1—more than a transcription factor?

Englert, C. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01277-8 · Cited by 56 · see citing works

Toward Identifying a Cellular Determinant of Telomerase Repression

Shay, J. W. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.4 · Cited by 39 · see citing works

Genetic Complementation of the Immortal Phenotype in Group D Cell Lines by Introduction of Chromosome 7

Ogata, T., Oshimura, M., Namba, M., Fujii, M., Oishi, M., & Ayusawa, D. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb02985.x · Cited by 32 · see citing works

Chromosome Translocation-Mediated Conversion of a Tumor Suppressor Gene into a Dominant Oncogene: Fusion of EWS1 to WT1 in Desmoplastic Small Round Cell Tumors

Rauscher, F. J. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60479-9_10 · Cited by 15 · see citing works

Human Telomerase and Its Regulation

Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works

A tumor suppressor and oncogene: the WT1 story

Yang, L., Han, Y., Saiz, F. S., & Minden, M. D. (2007) · Leukemia · doi:10.1038/sj.leu.2404624 · Cited by 472 · see citing works

WT1 proteins: functions in growth and differentiation

Scharnhorst, V., van der Eb, A. J., & Jochemsen, A. G. (2001) · Gene · doi:10.1016/s0378-1119(01)00593-5 · Cited by 352 · see citing works

Natural and pharmacological regulation of telomerase

Mergny, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.839 · Cited by 351 · see citing works

Understanding and exploiting <i>hTERT</i> promoter regulation for diagnosis and treatment of human cancers

Kyo, S., Takakura, M., Fujiwara, T., & Inoue, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00878.x · Cited by 347 · see citing works

Wilms Tumor and the WT1 Gene

Lee, S. B., & Haber, D. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5131 · Cited by 284 · see citing works

Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

Poole, J. C., Andrews, L. G., & Tollefsbol, T. O. (2001) · Gene · doi:10.1016/s0378-1119(01)00440-1 · Cited by 275 · see citing works

Telomerase regulation and stem cell behaviour

Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232 · see citing works

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms

Horikawa, I., & Barrett, J. C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg085 · Cited by 207 · see citing works

Regulation of the human telomerase reverse transcriptase gene

Ducrest, A., Szutorisz, H., Lingner, J., & Nabholz, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205081 · Cited by 184 · see citing works

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

Zhang, Y., Toh, L.-L., Lau, P., & Wang, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368282 · Cited by 181 · see citing works

Sp1 and Sp3 Recruit Histone Deacetylase to Repress Transcription of Human Telomerase Reverse Transcriptase (hTERT) Promoter in Normal Human Somatic Cells

Won, J., Yim, J., & Kim, T. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206064200 · Cited by 180 · see citing works

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?

Kyo, S., & Inoue, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205163 · Cited by 173 · see citing works

Identification of Mad as a repressor of the human telomerase (hTERT) gene

Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161 · see citing works

Prostaglandins, but not tumor-derived IL-10, shut down concomitant tumor-specific CTL responses during murine plasmacytoma progression

Specht, C., Bexten, S., Kölsch, E., & Pauels, H. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(200002)9999:9999 · Cited by 31 · see citing works

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

Ramlee, M. K., Wang, J., Toh, W. H., & Li, S. (2016) · Genes · doi:10.3390/genes7080050 · Cited by 149 · see citing works

Telomerase activation, cellular immortalization and cancer

Hahn, W. C., & Meyerson, M. M. (2001) · Annals of Medicine · doi:10.3109/07853890109002067 · Cited by 141 · see citing works

CTCF binds the proximal exonic region of hTERT and inhibits its transcription

Renaud, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki989 · Cited by 137 · see citing works

E2F-1 represses transcription of the human telomerase reverse transcriptase gene

Crowe, D. L. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2789 · Cited by 135 · see citing works

Genetic and epigenetic modulation of telomerase activity in development and disease

Liu, L., Lai, S. R., Andrews, L. G., & Tollefsbol, T. O. (2004) · Gene · doi:10.1016/j.gene.2004.06.011 · Cited by 121 · see citing works

On the road to immortality: hTERT upregulation in cancer cells

Janknecht, R. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00356-4 · Cited by 116 · see citing works

Variation at theTERTlocus and predisposition for cancer

Baird, D. M. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000147x · Cited by 115 · see citing works

Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT

Lv, J., Liu, H., Wang, Q., Tang, Z., Hou, L., & Zhang, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.235 · Cited by 115 · see citing works

Telomerase inhibition as cancer therapy

Saretzki, G. C. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00708-5 · Cited by 114 · see citing works

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

Majumdar, A. S., Hughes, D. E., Lichtsteiner, S., Wang, Z., LEBKOWSKI, J. S., & Vasserot, A. P. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301421 · Cited by 112 · see citing works

Telomeres and immunological diseases of aging.

Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M. (2010) · Gerontology · doi:10.1159/000268620 · Cited by 108 · see citing works

Genistein Represses Telomerase Activity via Both Transcriptional and Posttranslational Mechanisms in Human Prostate Cancer Cells

Jagadeesh, S., Kyo, S., & Banerjee, P. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2494 · Cited by 106 · see citing works

The Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus Transactivates the Telomerase Reverse Transcriptase Promoter

Knight, J. S., Cotter, M. A., & Robertson, E. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101890200 · Cited by 103 · see citing works

Telomerase: regulation, function and transformation

Dong, C. K., Masutomi, K., & Hahn, W. C. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.12.005 · Cited by 94 · see citing works

Telomeres and telomerase as targets for anticancer drug development

Olaussen, K. A., Dubrana, K., Dômont, J., Spano, J., Sabatier, L., & Soria, J. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.08.007 · Cited by 92 · see citing works

Stress and immunosenescence: The role of telomerase

de Punder, K., Heim, C. C., Wadhwa, P. D., & Entringer, S. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.019 · Cited by 90 · see citing works

Telomere Maintenance as a Target for Drug Discovery

Sekaran, V. G., Soares, J., & Jarstfer, M. B. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400528t · Cited by 90 · see citing works

Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1

Sim, E. U., Smith, A. G., Szilagi, E., Rae, F., Ioannou, P. A., Lindsay, M. H., & Little, M. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205373 · Cited by 90 · see citing works

Downstream E-Box–mediated Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene Transcription: Evidence for an Endogenous Mechanism of Transcriptional Repression

Horikawa, I., Cable, P. L., Mazur, S. J., Appella, E., Afshari, C. A., & Barrett, J. C. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e01-11-0107 · Cited by 88 · see citing works

Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.

Ducrest, A., Amacker, M., Mathieu, Y., Cuthbert, A. P., Trott, D. A., Newbold, R. F., Nabholz, M., & Lingner, J. (2001) · PubMed · Cited by 85 · see citing works

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells

Lopatina, N., Poole, J. C., Saldanha, S. N., Hansen, N. J., Key, J. S., Pita, M. A., Andrews, L. G., & Tollefsbol, T. O. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01033-7 · Cited by 82 · see citing works

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

Zhu, J., Zhao, Y., & Wang, S. (2010) · Protein & Cell · doi:10.1007/s13238-010-0014-1 · Cited by 81 · see citing works

Telomerase regulation at the crossroads of cell fate

Ćukušić, A., Vidaček, N. Š., Sopta, M., & Rubelj, I. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167812 · Cited by 80 · see citing works

NFX1-123 and Poly(A) Binding Proteins Synergistically Augment Activation of Telomerase in Human Papillomavirus Type 16 E6-Expressing Cells

Katzenellenbogen, R. A., Egelkrout, E. M., Vliet-Gregg, P. A., Gewin, L. C., Gafken, P. R., & Galloway, D. A. (2007) · Journal of Virology · doi:10.1128/jvi.02007-06 · Cited by 80 · see citing works

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

Reddel, R. R. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140630101047 · Cited by 78 · see citing works

Transcriptional activation of c-myc proto-oncogene by WT1 protein

Han, Y., San‐Marina, S., Liu, J., & Minden, M. D. (2004) · Oncogene · doi:10.1038/sj.onc.1207609 · Cited by 76 · see citing works

Telomerase regulation

Cifuentes‐Rojas, C., & Shippen, D. E. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.10.003 · Cited by 75 · see citing works

CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia

Bechter, O. E., Eisterer, W., Dlaska, M., Kühr, T., & Thaler, J. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00760-3 · Cited by 72 · see citing works

Identification of PITX1 as a TERT Suppressor Gene Located on Human Chromosome 5

Qi, D.-L., Ohira, T., Fujisaki, C., Inoue, T., Ohta, T., Osaki, M., Ohshiro, E., Seko, T., Aoki, S., Oshimura, M., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00470-10 · Cited by 70 · see citing works

miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level

Gao, S., Xing, C., Chen, C., Lin, S., Dong, P., & Yu, F. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-110 · Cited by 68 · see citing works

Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation

Liu, L., Saldanha, S. N., Pate, M. S., Andrews, L. G., & Tollefsbol, T. O. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20058 · Cited by 65 · see citing works

Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells

Won, J., Yim, J., & Kim, T. K. (2002) · The FASEB Journal · doi:10.1096/fj.02-0311fje · Cited by 65 · see citing works

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

de Wilde, J., Kooter, J. M., Overmeer, R., Claassen-Kramer, D., Meijer, C. J. L. M., Snijders, P. J. F., & Steenbergen, R. D. M. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-271 · Cited by 62 · see citing works

CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma

Zhang, C., Guo, X., Jiang, G., Zhang, L., Yang, Y., Shen, F., Wu, M., & Wei, L. (2008) · International Journal of Cancer · doi:10.1002/ijc.23650 · Cited by 59 · see citing works

Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-γ induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression

Lee, S., Kim, J., Lee, H., Cho, Y.-S., Oh, S.-H., Kim, Y.-J., Jung, C.-H., Zhang, W., & Lee, J.-H. (2003) · Oncogene · doi:10.1038/sj.onc.1206133 · Cited by 54 · see citing works

Human telomerase expression regulation

Machnik, M., Wojtyla, A., & Rubiś, B. (2011) · Biochemistry and Cell Biology · doi:10.1139/o11-037 · Cited by 53 · see citing works

Telomerase as a useful target in cancer fighting—the breast cancer case

Hołysz, H., Lipińska, N., Paszel-Jaworska, A., & Rubiś, B. (2013) · Tumor Biology · doi:10.1007/s13277-013-0757-4 · Cited by 52 · see citing works

Central role of PI3K in transcriptional activation of hTERT in HTLV-I–infected cells

Bellon, M., & Nicot, C. (2008) · Blood · doi:10.1182/blood-2008-01-134692 · Cited by 51 · see citing works

hTERT Can Function with Rabbit Telomerase RNA: Regulation of Gene Expression and Attenuation of Apoptosis

Xiang, H., Wang, J., Mao, Y., & Li, D. W.-C. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3834 · Cited by 51 · see citing works

Tumor-Specific Gene Therapy for Undifferentiated Thyroid Carcinoma Utilizing the Telomerase Reverse Transcriptase Promoter

Takeda, T., Inaba, H., Yamazaki, M., Kyo, S., Miyamoto, T., Suzuki, S., Ehara, T., Kakizawa, T., Hara, M., DeGroot, L. J., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021856 · Cited by 45 · see citing works

Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFβ

Hu, B., Tack, D. C., Liu, T., Wu, Z., Ullenbruch, M. R., & Phan, S. H. (2005) · Oncogene · doi:10.1038/sj.onc.1209140 · Cited by 44 · see citing works

Small-molecule-based identification of dynamic assembly of E2F–pocket protein–histone deacetylase complex for telomerase regulation in human cells

Won, J., Chang, S., Oh, S., & Kim, T. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401801101 · Cited by 44 · see citing works

Telomerase: biology and phase I trials

Kèlland, L. R. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00226-6 · Cited by 44 · see citing works

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways

Sitaram, R. T., Degerman, S., Ljungberg, B., Andersson, E., Oji, Y., Sugiyama, H., Roos, G., & Li, A. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605878 · Cited by 39 · see citing works

Effective treatment of leukemic cell lines with wt1 siRNA

Glienke, W., Maute, L., Koehl, U., Esser, R., Milz, E., & Bergmann, L. (2007) · Leukemia · doi:10.1038/sj.leu.2404878 · Cited by 39 · see citing works

The molecular biology of Wilms' tumour

Brown, K. W., & Malik, K. T. A. (2001) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399401003027 · Cited by 39 · see citing works

Transcriptional Activation of hTERT, the Human Telomerase Reverse Transcriptase, by Nuclear Factor of Activated T Cells

Chebel, A., Rouault, J.-P., Urbanowicz, I., Baseggio, L., Chien, W. W., Salles, G., & Ffrench, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009183 · Cited by 38 · see citing works

Telomerase, Telomerase Inhibition, and Cancer

Ahmed, A., & Tollefsbol, T. O. (2003) · Rejuvenation Research · doi:10.1089/109454503323028911 · Cited by 38 · see citing works

Telomeres, Telomerase, and Telomerase Inhibition: Clinical Implications for Cancer

Ahmed, A., & Tollefsbol, T. O. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1601-5215.2002.51019.x · Cited by 38 · see citing works

Telomerase as a new target for the treatment of hormone-refractory prostate cancer

Biroccio, A., & Leonetti, C. (2004) · Endocrine Related Cancer · doi:10.1677/erc.1.00764 · Cited by 37 · see citing works

Diverse regulatory manners of human telomerase reverse transcriptase

Jie, M., Chang, X., Zeng, S., Liu, C., Liao, G., Wu, Y., Liu, C., Hu, C.-J., Yang, S., & Li, X. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0372-0 · Cited by 34 · see citing works

Transcriptional Silencing of a Novel hTERT Reporter Locus during In Vitro Differentiation of Mouse Embryonic Stem Cells

Wang, S., Hu, C., & Zhu, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0840 · Cited by 34 · see citing works

Telomere/telomerase interplay in virus‐driven and virus‐independent lymphomagenesis: pathogenic and clinical implications

Dolcetti, R., & Rossi, A. D. (2010) · Medicinal Research Reviews · doi:10.1002/med.20211 · Cited by 33 · see citing works

Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells

Azouz, A., Wu, Y.-L., Hillion, J., Tárkányi, I., Karniguian, A., Aradi, J., Lanotte, M., Chen, G.-Q., Chehna, M. F., & Ségal-Bendirdjian, E. (2010) · Leukemia · doi:10.1038/leu.2009.283 · Cited by 33 · see citing works

Gene expression profiling to identify markers associated with deregulated hTERT in HPV‐transformed keratinocytes and cervical cancer

de Wilde, J., Wilting, S. M., Meijer, C. J. L. M., van de Wiel, M. A., Ylstra, B., Snijders, P. J. F., & Steenbergen, R. D. M. (2007) · International Journal of Cancer · doi:10.1002/ijc.23210 · Cited by 31 · see citing works

Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter

Renaud, S., Bosman, F. T., & Benhattar, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02775-4 · Cited by 31 · see citing works

A Review of the Wilms' Tumor 1 Gene (WT1) and Its Role in Hematopoiesis and Leukemia

Algar, E. M. (2002) · Stem Cells and Development · doi:10.1089/15258160260194749 · Cited by 29 · see citing works

Dissecting the non-canonical functions of telomerase

Parkinson, E. K., Fitchett, C., & Cereser, B. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167813 · Cited by 28 · see citing works

Mechanisms for telomerase gene control in aging cells and tumorigenesis

Tollefsbol, T. O., & Andrews, L. G. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1241 · Cited by 28 · see citing works

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

Jeitany, M., Pineda, J. R., Liu, Q., Porreca, R. M., Hoffschir, F., Desmaze, C., Silvestre, D. C., Mailliet, P., Junier, M., Londoño‐Vallejo, A., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29171 · Cited by 27 · see citing works

Telomerase regulation in hematological cancers: A matter of stemness?

Deville, L., Hillion, J., & Ségal-Bendirdjian, E. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.016 · Cited by 27 · see citing works

Silencing of the Expression of Pluripotent Driven-Reporter Genes Stably Transfected into Human Pluripotent Cells

Stewart, R., Yang, C., Anyfantis, G., Przyborski, S. A., Hole, N., Strachan, T., Stojković, M., Keith, W. N., Armstrong, L., & Lako, M. (2008) · Regenerative Medicine · doi:10.2217/17460751.3.4.505 · Cited by 26 · see citing works

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation

Armstrong, L., Lako, M., van Herpe, I., Evans, J., Saretzki, G. C., & Hole, N. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.07.005 · Cited by 26 · see citing works

An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes

Xu, M., Katzenellenbogen, R. A., Grandori, C., & Galloway, D. A. (2013) · Virology · doi:10.1016/j.virol.2013.07.014 · Cited by 25 · see citing works

The role of telomerase and viruses interaction in cancer development, and telomerase-dependent therapeutic approaches

Jeda, A. S., Badrzadeh, F., Esghaei, M., & Abdoli, A. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100323 · Cited by 24 · see citing works

Human chromosome 5 carries a putative telomerase repressor gene

Kugoh, H., Shigenami, K., Funaki, K., Barrett, J. C., & Oshimura, M. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10135 · Cited by 24 · see citing works

Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system

Kirch, H.-C., Ruschen, S., Brockmann, D., Esche, H., Horikawa, I., Barrett, J. C., Opalka, B., & Hengge, U. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205965 · Cited by 23 · see citing works

Infectivity enhanced, hTERT promoter-based conditionally replicative adenoviruses are useful for SCLC treatment

Uchino, J., Takayama, K., Harada, A., Kawakami, Y., Inoue, H., Curiel, D. T., & Nakanishi, Y. (2005) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700838 · Cited by 21 · see citing works

Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome

Poloni, A., Serrani, F., Berardinelli, E., Maurizi, G., Mariani, M., Costantini, B., Trappolini, S., Mancini, S., Olivieri, A., & Leoni, P. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.07.022 · Cited by 20 · see citing works

Expression profile of significant immortalization genes in colon cancer

Witkowska (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000348 · Cited by 20 · see citing works

Telomere Maintenance as Therapeutic Target in Embryonal Tumours

Shalaby, T., Hiyama, E., & Grotzer, M. A. (2010) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611009030196 · Cited by 19 · see citing works

Signaling on telomerase: a master switch in cell aging and immortalization

Li, H., & Liu, J. (2002) · Biogerontology · doi:10.1023/a:1015232102470 · Cited by 19 · see citing works

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

Szutorisz, H., Palmqvist, R., Roos, G., Stenling, R., Schorderet, D. F., Reddel, R. R., Lingner, J., & Nabholz, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204346 · Cited by 18 · see citing works

Telomerase reverse transcriptase catalytic subunit expression and proliferation index in Wilms tumor

Dınız, G., Aktaş, S., Yıldırım, A. T., Temir, G., Ortaç, R., & Vergin, C. R. (2011) · Tumor Biology · doi:10.1007/s13277-011-0178-1 · Cited by 17 · see citing works

The 58-kDa microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF)

Hsu, C.-C., Chen, C.-H., Hsu, T., Hung, J., Ko, J., Zhang, B., Lee, Y., Chen, H.-K., Chang, W., & Lin, D.-Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.12.004 · Cited by 17 · see citing works

Telomerase activity in high‐grade cervical lesions is associated with allelic imbalance at 6Q14–22

van Duin, M., Steenbergen, R. D. M., de Wilde, J., Helmerhorst, T. J. M., Verheijen, R. H. M., Risse, E. K. J., Meijer, C. J. L. M., & Snijders, P. J. F. (2003) · International Journal of Cancer · doi:10.1002/ijc.11145 · Cited by 17 · see citing works

Tumor Suppressors p53, p63TAα, p63TAy, p73α, and p73β Use Distinct Pathways to Repress Telomerase Expression

Yao, Y., Bellon, M., Shelton, S. N., & Nicot, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.319236 · Cited by 16 · see citing works

Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer

Yoon, J. H., Seo, H. S., Choi, W., Kim, O., Nam, S. W., Lee, J. Y., & Park, W. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2586 · Cited by 15 · see citing works

Telomerase and oral cancer

Sumida, T., & Hamakawa, H. (2001) · Oral Oncology · doi:10.1016/s1368-8375(00)00132-9 · Cited by 15 · see citing works

Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT

Tang, Z., Zhao, Y., Mei, F., Yang, S., Li, X., Lv, J., Hou, L., & Zhang, B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.201 · Cited by 15 · see citing works

Purification and identification of a transcription factor, USF‐2, binding to E‐box element in the promoter of human telomerase reverse transcriptase (hTERT)

Jiang, S., Galindo, M. R., & Jarrett, H. W. (2009) · PROTEOMICS · doi:10.1002/pmic.200800693 · Cited by 14 · see citing works

Repression of Human Telomerase Reverse Transcriptase Using Artificial Zinc Finger Transcription Factors

Sohn, J. H., Yeh, B., Choi, J.-W., Yoon, J., Namkung, J., Park, K.-K., & Kim, H.-W. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0141 · Cited by 13 · see citing works

hTERT mRNA Partially Regulates Telomerase Activity in Gastric Adenocarcinoma and Adjacent Normal Gastric Mucosa

Barclay, J., Morris, A. G., & Nwokolo, C. U. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2776-5 · Cited by 13 · see citing works

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA

Mecucci, C., Rosati, R., & Starza, R. L. (2002) · Reviews in Clinical and Experimental Hematology · doi:10.1046/j.1468-0734.2002.00060.x · Cited by 12 · see citing works

The evidences of human Orphan Receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription

Wang, Q., Bai, Z., Li, X., Hou, L., & Zhang, B. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.03.032 · Cited by 12 · see citing works

MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene

Shi, L., Li, M., & Su, B. (2012) · Gene · doi:10.1016/j.gene.2011.12.053 · Cited by 18 · see citing works

Identification of Mad as a repressor of the human telomerase (hTERT) gene

Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161 · see citing works

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways

Sitaram, R. T., Degerman, S., Ljungberg, B., Andersson, E., Oji, Y., Sugiyama, H., Roos, G., & Li, A. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605878 · Cited by 39 · see citing works

Transcriptional repression by the proximal exonic region at the human TERT gene

Wong, T. C., Sokol, E. S., Schep, A. N., Punjiya, M., Tran, D. A., Allan, D., & Drewell, R. A. (2011) · Gene · doi:10.1016/j.gene.2011.07.016 · Cited by 2 · see citing works

TAK1 represses transcription of the human telomerase reverse transcriptase gene

Fujiki, T., Miura, T., Maura, M., Shiraishi, H., Nishimura, S.-I., IMADA, Y., Uehara, N., Tashiro, K., Shirahata, S., & Katakura, Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210331 · Cited by 42 · see citing works