CoChat
Sign Up
Cited by 312Cancer survivorship and careMenopause: Health Impacts and TreatmentsSexual function and dysfunction studies

Managing Menopausal Symptoms in Breast Cancer Survivors: Results of a Randomized Controlled Trial

Ganz, P. A.·2000·Journal of the National Cancer Institute
DOI 10.1093/jnci/92.13.1054
Open this paper in CoChat — free account

Abstract

BACKGROUND: Menopausal symptoms (e.g., hot flashes, vaginal dryness, and stress urinary incontinence) are very common in breast cancer survivors and cannot be managed with standard estrogen replacement therapy (ERT) in these patients. The purpose of this study was to test the efficacy of a comprehensive menopausal assessment (CMA) intervention program in achieving relief of symptoms, the improvement in quality of life (QOL), and sexual functioning in breast cancer survivors. METHODS: Using a two-group, randomized controlled design, we assigned 76 postmenopausal breast cancer survivors with at least one severe target symptom either to the intervention group or to a usual-care group. Seventy-two women were evaluable at the end of the study period. The CMA intervention, delivered by a nurse practitioner, focused on symptom assessment, education, counseling and, as appropriate, specific pharmacologic and behavioral interventions for each of the three target symptoms. Psychosocial symptoms were assessed with the use of a self-report screening instrument, and distressed women were referred for counseling if needed. The intervention took place over a 4-month period. Outcomes measured were scores on a composite menopausal symptom scale, the RAND Short Form Health Survey Vitality Scale, and the Cancer Rehabilitation Evaluation System (CARES) Sexual Functioning Scale at baseline and at 4-month follow-up. All statistical tests were two-sided and were performed at the alpha =. 05 significance level. RESULTS: Patients receiving the intervention demonstrated statistically significant improvement (P =.0004) in menopausal symptoms but no significant change in vitality (P =.77). Sexual functioning was statistically significantly improved (P =.04) in the treatment group compared with the usual-care group. CONCLUSIONS: A clinical assessment and intervention program for menopausal symptom management in breast cancer survivors is feasible and acceptable to patients, leading to reduction in symptoms and improvement in sexual functioning. Measurable improvement in a general QOL measure was not demonstrated.

Integrity signals

Registry

Crossref · 10.1093/jnci/92.13.1054

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ganz, P. A.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Ganz, P. A.
ORCID
Ganz, P. A.
Venue
Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2000-07-05
Volume
92
Issue
13
Pages
1054-1064
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/92.13.1054
OpenAlex
W2163634728
Cited by
312
References
47
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 6 · 2015: 11 · 2014: 15 · 2013: 21 · 2012: 23
FWCI
4.84
Type
journal article
Language
en
Open access
closed
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords
menopausal symptoms, breast cancer survivors, hot flashes, vaginal dryness, stress urinary incontinence, sexual function, quality of life, estrogen replacement therapy, psychosocial distress, cancer rehabilitation
MeSH terms
Behavior Therapy, Breast Neoplasms, Female, Humans, Mass Screening, Menopause, Middle Aged, Patient Education as Topic, Quality of Life, Surveys and Questionnaires, Sex Counseling, Treatment Outcome, Survivors, Heterosexuality

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review