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Cited by 1,142Sleep and Work-Related FatigueCircadian rhythm and melatoninCancer Risks and Factors

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study

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Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., Colditz, G. A.·2001·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/93.20.1563
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Abstract

BACKGROUND: Melatonin shows potential oncostatic action, and light exposure during night suppresses melatonin production. There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer. METHODS: We examined the relationship between breast cancer and working on rotating night shifts during 10 years of follow-up in 78 562 women from the Nurses' Health Study. Information was ascertained in 1988 about the total number of years during which the nurses had worked rotating night shifts with at least three nights per month. From June 1988 through May 1998, we documented 2441 incident breast cancer cases. Logistic regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs), adjusted for confounding variables and breast cancer risk factors. All statistical tests were two-sided. RESULTS: We observed a moderate increase in breast cancer risk among the women who worked 1-14 years or 15-29 years on rotating night shifts (multivariate adjusted RR = 1.08 [95% CI = 0.99 to 1.18] and RR = 1.08 [95% CI = 0.90 to 1.30], respectively). The risk was further increased among women who worked 30 or more years on the night shift (RR = 1.36; 95% CI = 1.04 to 1.78). The test for trend was statistically significant (P =.02). CONCLUSIONS: Women who work on rotating night shifts with at least three nights per month, in addition to days and evenings in that month, appear to have a moderately increased risk of breast cancer after extended periods of working rotating night shifts.

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  1. Cos, 1998, Cancer Research, 58, 4383
  2. Blask, 1999, Cancer Research, 59, 4693

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Metadata

Authors
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Schernhammer, E. S.
ORCID
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2001-10-17
Volume
93
Issue
20
Pages
1563-1568
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/93.20.1563
OpenAlex
W2142622103
Cited by
1,142
References
57
Citations by year
2026: 18 · 2025: 22 · 2024: 34 · 2023: 27 · 2022: 38 · 2021: 42 · 2020: 54 · 2019: 50 · 2018: 40 · 2017: 60 · 2016: 51 · 2015: 60 · 2014: 55 · 2013: 79 · 2012: 77
FWCI
40.32
Type
journal article
Language
en
Open access
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Environmental Health Sciences (ES62984)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
rotating night shifts, breast cancer risk, night work, melatonin, light exposure, nurses, occupational cancer risk
MeSH terms
Adult, Breast Neoplasms, Circadian Rhythm, Female, Follow-Up Studies, Humans, Light, Lighting, Melatonin, Middle Aged, Nurses, Pineal Gland, Surveys and Questionnaires, Risk, Risk Factors, Secretory Rate, Work Schedule Tolerance, Cohort Studies, Multicenter Studies as Topic, Incidence, Premenopause, Postmenopause

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