Rotating Night-Shift Work and the Risk of Breast Cancer in the Nurses' Health Studies
Open accessAbstract
In 2007, the International Agency for Research on Cancer declared shift work that involved circadian disruption to be a "probable" carcinogen (group 2A), noting that human evidence was limited. Using data from 2 prospective cohort studies, the Nurses' Health Study (1988-2012; n = 78,516) and Nurses' Health Study II (1989-2013; n = 114,559), we examined associations between rotating night-shift work and breast cancer risk. In the 2 cohorts, there were a total of 9,541 incident invasive breast malignancies and 24 years of follow-up. In the Nurses' Health Study, women with 30 years or more of shift work did not have a higher risk of breast cancer (hazard ratio (HR) = 0.95, 95% confidence interval (95% CI): 0.77, 1.17; P for trend = 0.63) compared with those who never did shift work, although follow-up occurred primarily after retirement from shift work. Among participants in the Nurses' Health Study II, who were younger than participants in the other cohort, the risk of breast cancer was significantly higher in women with 20 years or more of shift work at baseline, reflecting young-adult exposure (HR = 2.15, 95% CI: 1.23, 3.73; P for trend = 0.23), and was marginally significantly higher for women with 20 years or more of cumulative shift work when we used updated exposure information (HR = 1.40, 95% CI: 1.00, 1.97; P for trend = 0.74). In conclusion, long-term rotating night-shift work was associated with a higher risk of breast cancer, particularly among women who performed shift work during young adulthood. Further studies should explore the role of shift work timing on breast cancer risk.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Shift work is an independent risk factor for many chronic conditions, including heart disease.
“Shift work is an independent risk factor for many chronic conditions, including heart disease (133-136), perhaps due to recurring disruptions of the circadian clock itself (e.g., light exposure at unusual circadian phases), or perhaps due to misalignment between the circadian clock and the behaviors (e.g., sleeping and fasting during the day, and being active and eating across the night).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Estimating the world cancer burden: Globocan 2000
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2001) · International Journal of Cancer · doi:10.1002/ijc.1440 · Cited by 3,718 · see citing works
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142 · see citing works
Self-citationCarcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082 · see citing works
The dark side of light at night: physiological, epidemiological, and ecological consequences
Navara, K. J., & Nelson, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00473.x · Cited by 795 · see citing works
Gooley, J. J., Chamberlain, K., Smith, K. A., Khalsa, S. B. S., Rajaratnam, S. M. W., Van Reen, E., Zeitzer, J. M., Czeisler, C. A., & Lockley, S. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2098 · Cited by 565 · see citing works
Night work and risk of breast cancer
Schernhammer, E. S., Kroenke, C. H., Laden, F., & Hankinson, S. E. (2006) · Epidemiology · doi:10.1097/01.ede.0000190539.03500.c1 · Cited by 484 · see citing works
Self-citationBiological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects
Haus, E. L., & Smolensky, M. H. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9015-4 · Cited by 391 · see citing works
A Time to Work: Recent Trends in Shift Work and Flexible Schedules
McMenamin, T. M. (2007) · Monthly labor review · Cited by 389 · see citing works
Comparison of molecular phenotypes of ductal carcinoma in situand invasive breast cancer
Tamimi, R. M., Baer, H. J., Marotti, J. D., Galan, M. A., Galaburda, L., Fu, Y., Deitz, A. C., Connolly, J. L., Schnitt, S. J., Colditz, G. A., et al. (2008) · Breast Cancer Research · doi:10.1186/bcr2128 · Cited by 343 · see citing works
Self-citationBreast cancer and circadian disruption from electric lighting in the modern world
Stevens, R. G., Brainard, G. C., Blask, D. E., Lockley, S. W., & Motta, M. E. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21218 · Cited by 323 · see citing works
Self-citationMelatonin: an inhibitor of breast cancer
Hill, S. M., Belancio, V. P., Dauchy, R. T., Xiang, S., Brimer, S., Mao, L., Hauch, A. T., Lundberg, P. W., Summers, W. M., Yuan, L., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0030 · Cited by 322 · see citing works
Night-shift work and breast cancer – a systematic review and meta-analysis
Ijaz, S., Verbeek, J. H. A. M., Seidler, A., Lindbohm, M.-L., Ojajärvi, A., Orsini, N., Costa, G., & Neuvonen, K. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3371 · Cited by 243 · see citing works
Night shift work at specific age ranges and chronic disease risk factors
Ramin, C., Devore, E. E., Wang, W., Pierre-Paul, J., Wegrzyn, L. R., & Schernhammer, E. S. (2015) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102292 · Cited by 228 · see citing works
Self-citationCase–control study of shift-work and breast cancer risk in Danish nurses: Impact of shift systems
Hansen, J., & Stevens, R. G. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2011.07.005 · Cited by 226 · see citing works
Self-citationHansen, J., & Lassen, C. F. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100240 · Cited by 214 · see citing works
Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work
Schernhammer, E. S., ROSNER, B. A., Willett, W. C., Laden, F., Colditz, G. A., & Hankinson, S. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.936.13.6 · Cited by 214 · see citing works
Self-citationNight-shift work and risk of breast cancer: a systematic review and meta-analysis
Kamdar, B. B., Tergas, A. I., Mateen, F. J., Bhayani, N. H., & Oh, J. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2433-1 · Cited by 209 · see citing works
A meta-analysis on dose–response relationship between night shift work and the risk of breast cancer
Wang, F., Yeung, K.-W., Chan, W. C., Kwok, C. C.-H., Leung, S.-L., Wu, Ç., Chan, E. Y. Y., Yu, I. T.-S., Yang, X. R., & Tse, L. A. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt283 · Cited by 197 · see citing works
Breast cancer and night work among Norwegian nurses
Lie, J.-A. S., Roessink, J., & Kjærheim, K. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-3639-2 · Cited by 188 · see citing works
Epidemiology of Uriniary Melatonin in Women and Its Relation to Other Hormones and Night Work
Stevens, R. G. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0420 · Cited by 184 · see citing works
Self-citationJia, Y., Lu, Y., Wu, K., Lin, Q., Shen, W., Zhu, M., Huang, S., & Chen, J. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.01.005 · Cited by 174 · see citing works
Circadian disrupting exposures and breast cancer risk: a meta-analysis
He, C., Anand, S. T., Ebell, M. H., Vena, J. E., & Robb, S. W. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-014-0986-x · Cited by 165 · see citing works
Night-Shift Work and Breast Cancer Risk in a Cohort of Chinese Women
Pronk, A., Ji, B. T., Shu, X. O., Xue, S., Yang, G., Li, H. L., Rothman, N., Gao, Y. T., Zheng, W., & Chow, W. H. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq029 · Cited by 160 · see citing works
Hefti, M. M., Hu, R., Knoblauch, N., Collins, L. C., Haibe‐Kains, B., Tamimi, R. M., & Beck, A. H. (2013) · Breast Cancer Research · doi:10.1186/bcr3462 · Cited by 155 · see citing works
Self-citationNight work and breast cancer: a population-based case-control study in France (the CECILE study)
Menegaux, F., Truong, T., Anger, A., Cordina‐Duverger, E., Lamkarkach, F., Arveux, P., Kerbrat, P., Févotte, J., & Guénel, P. (2013) · International Journal of Cancer · doi:10.1002/ijc.27669 · Cited by 133 · see citing works
Early life events and conditions and breast cancer risk: From epidemiology to etiology
Trichopoulos, D., Adami, H., Ekbom, A., Hsieh, C., & Λάγιου, Π. (2007) · International Journal of Cancer · doi:10.1002/ijc.23303 · Cited by 120 · see citing works
Breast cancer among shift workers: results of the WOLF longitudinal cohort study
Knutsson, A., Alfredsson, L. S., Karlsson, B., Åkerstedt, T., Fransson, E. I., Westerholm, P. J. M., & Westerlund, H. (2012) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3323 · Cited by 114 · see citing works
Breast cancer risk and night shift work in a case–control study in a Spanish population
Papantoniou, K., Castaño‐Vinyals, G., Espinosa, A., Aragonés, N., Pérez‐Gómez, B., Ardanáz, E., Altzibar, J. M., Martín, V., Gómez‐Acebo, I., Llorca, J., et al. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0073-y · Cited by 104 · see citing works
Bracci, M., Manzella, N., Copertaro, A., Staffolani, S., Strafella, E., Barbaresi, M., Copertaro, B., Rapisarda, V., Valentino, M., & Santarelli, L. (2014) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3414 · Cited by 103 · see citing works
Night work and breast cancer in women: a Swedish cohort study
Åkerstedt, T., Knutsson, A., Narusyte, J., Svedberg, P., Kecklund, G., & Alexanderson, K. A. E. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008127 · Cited by 99 · see citing works
Mammographic Screening and Risk Factors for Breast Cancer
Cook, N. R., ROSNER, B. A., Hankinson, S. E., & Colditz, G. A. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp304 · Cited by 58 · see citing works
Self-citationROSNER, B. A., Eliassen, A. H., Toriola, A. T., Hankinson, S. E., Willett, W. C., Natarajan, L., & Colditz, G. A. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3344-0 · Cited by 49 · see citing works
Self-citationIncidental findings in population imaging revisited
Bunnik, E. M., & Vernooij, M. W. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0123-0 · Cited by 27 · see citing works
Tsai, R., Luckhaupt, S. E., Sweeney, M. H., & Calvert, G. M. (2013) · American Journal of Industrial Medicine · doi:10.1002/ajim.22285 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian Mechanisms in Medicine
Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519 · see citing works
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 537 · see citing works
Circadian rhythm as a therapeutic target
Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 501 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Carcinogenicity of night shift work
Ward, E. M., Germolec, D. R., Kogevinas, M., McCormick, D. L., Vermeulen, R. C. H., Anisimov, V. N., Aronson, K. J., Bhatti, P., Cocco, P., Costa, G., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30455-3 · Cited by 390 · see citing works
Self-citationMoreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 223 · see citing works
The Mammalian Circadian Timing System and the Suprachiasmatic Nucleus as Its Pacemaker
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2019) · Biology · doi:10.3390/biology8010013 · Cited by 192 · see citing works
Cordina‐Duverger, E., Menegaux, F., Popa, A., Rabstein, S., Harth, V., Pesch, B., Brüning, T., Fritschi, L., Glass, D. C., Heyworth, J. S., et al. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0368-x · Cited by 187 · see citing works
Night Shift Work and Risk of Breast Cancer
Hansen, J. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0155-y · Cited by 171 · see citing works
Shift Work, Chronotype, and Melatonin Rhythm in Nurses
Razavi, P., Devore, E. E., Bajaj, A., Lockley, S. W., Figueiro, M. G., Ricchiuti, V., Gauderman, W. J., Hankinson, S. E., Willett, W. C., & Schernhammer, E. S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1018 · Cited by 168 · see citing works
Self-citationWhat Is Known about Breast Cancer in Young Women?
Zhu, J. W., Charkhchi, P., Adekunte, S., & Akbari, M. R. (2023) · Cancers · doi:10.3390/cancers15061917 · Cited by 171 · see citing works
Rotating night shift work and colorectal cancer risk in the nurses’ health studies
Papantoniou, K., Devore, E. E., MASSA, J. S., Strohmaier, S., Vetter, C., Yang, L., Shi, Y. X., Giovannucci, E. L., Speizer, F. E., & Schernhammer, E. S. (2018) · International Journal of Cancer · doi:10.1002/ijc.31655 · Cited by 147 · see citing works
Self-citationCircadian control of lung inflammation in influenza infection
Sengupta, S., Tang, S. Y., Devine, J. C., Anderson, S. T., Nayak, S., Zhang, S., Valenzuela, A., Fisher, D. G., Grant, G. R., López, C. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11400-9 · Cited by 143 · see citing works
A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
Daly, A., Rolph, R. C., Cutress, R., & Copson, E. (2021) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s268401 · Cited by 129 · see citing works
Genetics of the human circadian clock and sleep homeostat
Ashbrook, L. H., Krystal, A. D., Fu, Y.-H., & Ptáček, L. J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0476-7 · Cited by 123 · see citing works
Maiese, K. (2017) · Current Neurovascular Research · doi:10.2174/1567202614666170718092010 · Cited by 120 · see citing works
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 113 · see citing works
Evidence for widespread dysregulation of circadian clock progression in human cancer
Shilts, J., Chen, G., & Hughey, J. (2018) · PeerJ · doi:10.7717/peerj.4327 · Cited by 99 · see citing works
Night shift work is associated with an increased risk of asthma
Maidstone, R. J., Turner, J., Vetter, C., Dashti, H. S., Saxena, R., Scheer, F. A. J. L., Shea, S. A., Kyle, S. D., Lawlor, D. A., Loudon, A. S. I., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215218 · Cited by 102 · see citing works
Shift work and sleep: medical implications and management
McFarlane, S. I. (2017) · Sleep Medicine and Disorders International Journal · doi:10.15406/smdij.2017.01.00008 · Cited by 94 · see citing works
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 93 · see citing works
Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis
Dun, A., Zhao, X., Jin, X., Wei, T., Gao, X., Wang, Y., & Hou, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01006 · Cited by 99 · see citing works
Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer
Eve, L., Fervers, B., Romancer, M. L., & Étienne-Selloum, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239139 · Cited by 94 · see citing works
Stokes, K., Nunes, M., Trombley, C., Flôres, D. E. F. L., Wu, G., Taleb, Z., Alkhateeb, A., Banskota, S., Harris, C. R., Love, O. P., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.001 · Cited by 94 · see citing works
Night-shift work duration and breast cancer risk: an updated systematic review and meta-analysis
Manouchehri, E., Taghipour, A., Ghavami, V., Ebadi, A., Homaei, F., & Roudsari, R. L. (2021) · BMC Women s Health · doi:10.1186/s12905-021-01233-4 · Cited by 88 · see citing works
Clocking cancer: the circadian clock as a target in cancer therapy
Battaglin, F., Chan, P., Pan, Y., Soni, S., Qu, M., Spiller, E. R., Castanon, S. L., Torres, E. T. R., Mumenthaler, S. M., Kay, S. A., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01778-6 · Cited by 88 · see citing works
Bagheri Hosseinabadi, M., Ebrahimi, M. H., Khanjani, N., Biganeh, J., Mohammadi, S., & Abdolahfard, M. (2019) · Journal of Clinical Nursing · doi:10.1111/jocn.14778 · Cited by 87 · see citing works
Cancer in the Fourth Dimension: What Is the Impact of Circadian Disruption?
Pariollaud, M., & Lamia, K. A. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0413 · Cited by 86 · see citing works
An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer
Morales, S., Morell, S., León, J., Carazo, Á., Jiménez-López, J. C., & Morell, M. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00104 · Cited by 71 · see citing works
Night shift work and risk of breast cancer in women: the Generations Study cohort
Jones, M. E., Schoemaker, M. J., McFadden, E. C., Wright, L. B., Johns, L. E., & Swerdlow, A. J. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0485-7 · Cited by 65 · see citing works
Altered Circadian Rhythms and Breast Cancer: From the Human to the Molecular Level
Lin, H.-H., & Farkas, M. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00219 · Cited by 62 · see citing works
Shift Work and Respiratory Infections in Health-Care Workers
Loef, B., van Baarle, D., van der Beek, A. J., Sanders, E. A. M., Bruijning-Verhagen, P. C. J. L., & Proper, K. I. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy258 · Cited by 62 · see citing works
Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses' Health Study
Shi, H., Huang, T., Schernhammer, E. S., Sun, Q., & Wang, M. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.10450 · Cited by 61 · see citing works
Self-citationImpact of Shift Work on the Circadian Timing System and Health in Women
Kervezee, L., Shechter, A., & Boivin, D. B. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2018.04.003 · Cited by 57 · see citing works
Wei, F., Chen, W., & Lin, X. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02523-9 · Cited by 56 · see citing works
Ticking time bombs: connections between circadian clocks and cancer
Lamia, K. A. (2017) · F1000Research · doi:10.12688/f1000research.11770.1 · Cited by 56 · see citing works
Gehlert, S. J., Clanton, M. S., & on behalf of the Shift Work and Breast Cancer Strategic Advisory Group (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249544 · Cited by 55 · see citing works
Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine
Polívka, J., Altun, I., & Golubnitschaja, O. (2018) · The EPMA Journal · doi:10.1007/s13167-018-0129-7 · Cited by 55 · see citing works
Sleep and circadian rhythms: pillars of health—a Keystone Symposia report
Cable, J., Schernhammer, E. S., Hanlon, E. C., Vetter, C., Cedernaes, J., Makarem, N., Dashti, H. S., Shechter, A., Depner, C. M., Ingiosi, A. M., et al. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14661 · Cited by 51 · see citing works
Self-citationCircadian clocks: an overview on its adaptive significance
Krittika, S., & Yadav, P. (2020) · Biological Rhythm Research · doi:10.1080/09291016.2019.1581480 · Cited by 50 · see citing works
The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer
Morgan, M. N., Dvuchbabny, S., Martinez, C.-A., Kerr, B., Cistulli, P. A., & Cook, K. M. (2019) · Clocks & Sleep · doi:10.3390/clockssleep1040034 · Cited by 49 · see citing works
Relationship between Night Shifts and Risk of Breast Cancer among Nurses: A Systematic Review
Fagundo-Rivera, J., Gómez-Salgado, J. C., García‐Iglesias, J. J., Gómez-Salgado, C., Camacho-Martín, S., & Ruíz-Frutos, C. (2020) · Medicina · doi:10.3390/medicina56120680 · Cited by 50 · see citing works
Liu, W., Zhou, Z., Dong, D., Sun, L., & Zhang, G. (2018) · Disease Markers · doi:10.1155/2018/7925219 · Cited by 49 · see citing works
Salamanca‐Fernández, E., Rodríguez‐Barranco, M., Guevara, M., Ardanáz, E., Lima, A. O. D. L., & Sánchez, M. J. G. (2018) · Anales del Sistema Sanitario de Navarra · doi:10.23938/assn.0307 · Cited by 48 · see citing works
Napping on night‐shifts among nursing staff: A mixed‐methods systematic review
Li, H., Shao, Y., Xing, Z., Li, Y., Wang, S., Zhang, M., Ying, J., Shi, Y., & Sun, J. (2018) · Journal of Advanced Nursing · doi:10.1111/jan.13859 · Cited by 47 · see citing works
The diverse roles of the circadian clock in cancer
Fortin, B. M., Mahieu, A. L., Fellows, R. C., Kang, Y., Lewis, A. N., Ead, A., Lamia, K. A., Cao, Y., Pannunzio, N. R., & Masri, S. (2025) · Nature Cancer · doi:10.1038/s43018-025-00981-8 · Cited by 47 · see citing works
Association between circadian disruption and diseases: A narrative review
Hou, Y., Liu, L.-M., Chen, X., Li, Q., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118512 · Cited by 45 · see citing works
Reid, K. J., Weng, J. F., Ramos, A. R., Zee, P. C., Daviglus, M. L., Mossavar‐Rahmani, Y., Sotres‐Alvarez, D., Gallo, L. C., Chirinos, D. A., & Patel, S. R. (2018) · SLEEP · doi:10.1093/sleep/zsy131 · Cited by 42 · see citing works
Ramos, C. A., Ouyang, C., Qi, Y., Chung, Y., Cheng, C.-T., LaBarge, M. A., Seewaldt, V. L., & Ann, D. K. (2020) · iScience · doi:10.1016/j.isci.2020.100839 · Cited by 41 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Guijarro, L. G., Casanova, C., Coca, S., Álvarez‐Mon, M., Buján, J., García‐Honduvilla, N., & Asúnsolo, Á. (2020) · Cancers · doi:10.3390/cancers12092443 · Cited by 41 · see citing works
The regulation of circadian clock by tumor necrosis factor alpha
Ertosun, M. G., Koçak, G., & Özeş, O. N. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.04.001 · Cited by 40 · see citing works
Circadian rhythms and glial cells of the central nervous system
Brécier, A., Li, V. W., Smith, C. S., Halievski, K., & Ghasemlou, N. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12917 · Cited by 39 · see citing works
Time-Restricted Eating and Its Metabolic Benefits
Mishra, S., Persons, P. A., Lorenzo, A. M., Chaliki, S. S., & Bersoux, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227007 · Cited by 39 · see citing works
Abreu, M., Basti, A., Генов, Н., Mazzoccoli, G., & Relógio, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29847-z · Cited by 39 · see citing works
Guerrero‐Vargas, N. N., Zárate‐Mozo, C., Guzmán‐Ruiz, M. A., Cárdenas‐Rivera, A., & Escobar, C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24741 · Cited by 38 · see citing works
Faraut, B., Cordina‐Duverger, E., Aristizabal, G., Drogou, C., Gauriau, C., Sauvet, F., Lévi, F., Léger, D., & Guénel, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.939829 · Cited by 36 · see citing works
Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic
Sengupta, S., Ince, L. M., Sartor, F., Borrmann, H., Zhuang, X. A., Naik, A. S., Curtis, A. M., & McKeating, J. A. (2021) · Journal of Biological Rhythms · doi:10.1177/0748730420987669 · Cited by 37 · see citing works
Robbins, R., Underwood, P., Jackson, C. L., Jean-Louis, G., Madhavaram, S., Kuriakose, S., Vieira, D. L., & Buxton, O. M. (2021) · Workplace Health & Safety · doi:10.1177/21650799211020961 · Cited by 38 · see citing works
Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm
Maiese, K. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4971 · Cited by 36 · see citing works
Chen, M., Singh, A. K., & Repasky, E. A. (2020) · Cancers · doi:10.3390/cancers12123853 · Cited by 34 · see citing works
Csoma, B., & Bikov, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814145 · Cited by 33 · see citing works
Exploring the link between chronobiology and drug delivery: effects on cancer therapy
Albuquerque, T., Neves, A. R., Quintela, T., & Costa, D. R. B. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02106-x · Cited by 33 · see citing works
Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology
Nelson, N. G., Lombardo, J. F., Matlack, L. E., Smith, A. C., Hines, K., Shi, W., & Simone, N. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031331 · Cited by 33 · see citing works
Night Shift Work, DNA Methylation and Telomere Length: An Investigation on Hospital Female Nurses
Carugno, M., Maggioni, C., Crespi, E., Bonzini, M., Cuocina, S., Dioni, L., Tarantini, L., Consonni, D., Ferrari, L., & Pesatori, A. C. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16132292 · Cited by 32 · see citing works
BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work
Bracci, M., Ciarapica, V., Elexpuru-Zabaleta, M., Tartaglione, M. F., Pirozzi, S., Giuliani, L., Piva, F., Valentino, M., Ledda, C., Rapisarda, V., et al. (2019) · Cancers · doi:10.3390/cancers11081146 · Cited by 32 · see citing works
Self-citationNight Work, Rotating Shift Work, and the Risk of Cancer in Japanese Men and Women: The JACC Study
Arafa, A., Eshak, E. S., Iso, H., Muraki, I., & Tamakoshi, A. (2020) · Journal of Epidemiology · doi:10.2188/jea.je20200208 · Cited by 33 · see citing works
Irregular sleep and all-cause mortality: A large prospective cohort study
Omichi, C., Koyama, T., Kadotani, H., Ozaki, E., Tomida, S., Yoshida, T., Otonari, J., Ikezaki, H., Hara, M., Tanaka, K., et al. (2022) · Sleep Health · doi:10.1016/j.sleh.2022.08.010 · Cited by 31 · see citing works
Shift Work and Working at Night in Relation to Breast Cancer Incidence
Sweeney, M. R., Sandler, D. P., Niehoff, N. M., & White, A. J. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1314 · Cited by 30 · see citing works
Circadian Rhythm Sleep-Wake Disorders
Zee, P. C., & Abbott, S. M. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000884 · Cited by 30 · see citing works
Jensen, L. D., Oliva, D., Andersson, B., & Lewin, F. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10010-6 · Cited by 31 · see citing works
Regulation of Cytotoxic CD8+ T Cells by the Circadian Clock
Cermakian, N., & Labrecque, N. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200516 · Cited by 29 · see citing works
McNeil, J., Heer, E. V., Willemsen, R. F., Friedenreich, C. M., & Brenner, D. R. (2020) · Cancer Epidemiology · doi:10.1016/j.canep.2020.101729 · Cited by 29 · see citing works
Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock
Bottalico, L. N., & Weljie, A. M. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113650 · Cited by 27 · see citing works
Christensen, R. A. G., & Kirkham, A. A. (2021) · Nutrients · doi:10.3390/nu13103476 · Cited by 28 · see citing works
Exploring the impact of night shift work on methylation of circadian genes
Ritonja, J. A., Aronson, K. J., Flaten, L., Topouza, D. G., Duan, Q., Durocher, F., Tranmer, J. E., & Bhatti, P. (2021) · Epigenetics · doi:10.1080/15592294.2021.2009997 · Cited by 26 · see citing works
Endocrine rhythms and sport: it is time to take time into account
Bellastella, G., Bellis, A. D., Maiorino, M., Paglionico, V. A., Esposito, K., & Bellastella, A. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01038-1 · Cited by 27 · see citing works
Night Work and Breast Cancer Risk in Nurses: Multifactorial Risk Analysis
Gómez-Salgado, J. C., Fagundo-Rivera, J., Ortega‐Moreno, M., Allande‐Cussó, R., Ayuso-Murillo, D., & Ruíz-Frutos, C. (2021) · Cancers · doi:10.3390/cancers13061470 · Cited by 25 · see citing works
Wu, Y., Gui, S., Fang, Y., Zhang, M., & Hu, C. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116114 · Cited by 24 · see citing works
Shift work with and without night shifts and breast cancer risk in a cohort study from Finland
Härmä, M., Ojajärvi, A., Koskinen, A., Lie, J.-A. S., & Hansen, J. (2022) · Occupational and Environmental Medicine · doi:10.1136/oemed-2022-108347 · Cited by 24 · see citing works
The association between night shift work and breast cancer risk in the Finnish twins cohort
Schernhammer, E. S., Bogl, L. H., Hublin, C., Strohmaier, S., Żebrowska, M., Erber, A. C., Haghayegh, S., Papantoniou, K., Ollikainen, M., & Kaprio, J. A. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-00983-9 · Cited by 24 · see citing works
Self-citationYang, Z., Black, K., Ohman‐Strickland, P., Graber, J. M., Kipen, H. M., Fang, M., & Zarbl, H. (2024) · The FASEB Journal · doi:10.1096/fj.202302261rr · Cited by 25 · see citing works
Daghlas, I., Richmond, R. C., Lane, J. M., Dashti, H. S., Ollila, H. M., Schernhammer, E. S., Smith, G. D., Rutter, M. K., Saxena, R., & Vetter, C. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab031 · Cited by 23 · see citing works
Self-citationHow the Intensity of Night Shift Work Affects Breast Cancer Risk
Szkiela, M., Kusideł, E., Makowiec-Dąbrowska, T., & Kaleta, D. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094570 · Cited by 23 · see citing works
Hong, J., He, Y., Fu, R., Si, Y.-X., Xu, B., Xu, J., Li, X., & Mao, F. (2022) · Open Medicine · doi:10.1515/med-2022-0470 · Cited by 25 · see citing works
Pepin, E., Gillet, P., Sauvet, F., Gomez-Mérino, D., Thaon, I., Chennaoui, M., & Léger, D. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019098 · Cited by 23 · see citing works
Rotating night shift work and risk of multiple sclerosis in the Nurses’ Health Studies
Papantoniou, K., MASSA, J. S., Devore, E. E., Munger, K. L., Chitnis, T., Ascherio, A., & Schernhammer, E. S. (2019) · Occupational and Environmental Medicine · doi:10.1136/oemed-2019-106016 · Cited by 21 · see citing works
Self-citationStrohmaier, S., Devore, E. E., Vetter, C., Eliassen, A. H., ROSNER, B. A., Okereke, O. I., & Schernhammer, E. S. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00525-2 · Cited by 22 · see citing works
Self-citationChan, A. B., & Lamia, K. A. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12658 · Cited by 21 · see citing works
The tumor circadian clock: a new target for cancer therapy?
Kießling, S., & Cermakian, N. (2017) · Future Oncology · doi:10.2217/fon-2017-0456 · Cited by 21 · see citing works
Sanford, A. B. A., da Cunha, L. S., Machado, C. B., Pessoa, F. M. C. D. P., Silva, A. N. D. S., Ribeiro, R. M., Moreira, F. C., de Moraes, M. O., de Moraes, M. E. A., de Souza, L. E. B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158212 · Cited by 20 · see citing works
Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit
Skapetze, L., Owino, S., Lo, E. H., Arai, K., Merrow, M. W., & Harrington, M. E. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106120 · Cited by 20 · see citing works
Influence of light at night on allergic diseases: a systematic review and meta-analysis
Deprato, A., Maidstone, R. J., Cros, A. P., Adán, A., Haldar, P., Harding, B. N., Lacy, P., Melenka, L., Moitra, S., Navarro, J. F., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03291-5 · Cited by 22 · see citing works
Vieira, V. M., VoPham, T., Bertrand, K. A., James, P., DuPre, N. C., Tamimi, R. M., Laden, F., & Hart, J. E. (2019) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000080 · Cited by 19 · see citing works
Self-citationCircadian Disruption and Breast Cancer Risk: Evidence from a Case-Control Study in China
Song, S., Lei, L., Zhang, R., Liu, H., Du, J. H., Li, N., Chen, W., Peng, J., & Ren, J. (2023) · Cancers · doi:10.3390/cancers15020419 · Cited by 19 · see citing works
Cancer clocks in tumourigenesis: the p53 pathway and beyond
Stephenson, E. M., Usselmann, L. E. J., Tergaonkar, V., Virshup, D. M., & Dallmann, R. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0475 · Cited by 20 · see citing works
Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases
Bellastella, G., Maiorino, M. I., Scappaticcio, L., Bellis, A. D., Mercadante, S., Esposito, K., & Bellastella, A. (2021) · Life · doi:10.3390/life11050426 · Cited by 18 · see citing works
Night-shift work and risk of breast cancer in Korean women
Pham, T. T., Hwang, M., Lee, E. S., Kong, S., Jung, S.-Y., Lee, S., Kim, J., Ha, M., Kim, S. Y., & Park, B. (2019) · Clinical Epidemiology · doi:10.2147/clep.s199521 · Cited by 18 · see citing works
Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression
Shi, Y. X., Liu, L., Hamada, T., Nowak, J. A., Giannakis, M., Ma, Y., Song, M., Nevo, D., Kosumi, K., Gu, M., et al. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0325 · Cited by 21 · see citing works
Self-citationHarris, M. A., MacLeod, J. S., Kim, J., Pahwa, M., Tjepkema, M., Peters, P. A., & Demers, P. A. (2020) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxaa017 · Cited by 18 · see citing works
Night Work, Rotating Shift Work, and the Risk of Cancer in Japanese Men and Women: The JACC Study
Abdellatif, E. A. A., & アブドゥラティフ, エ. ア. ア. (n.d.) · OUKA (Osaka University Knowledge Archive) (Osaka University) · Cited by 18 · see citing works
- Authors
- Wegrzyn, L. R., Tamimi, R. M., Rosner, B. A., Brown, S. B., Stevens, R. G., Eliassen, A. H., Laden, F., Willett, W. C., Hankinson, S. E., & Schernhammer, E. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Schernhammer, Eva S.
- ORCID
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-08-03
- Volume
- 186
- Issue
- 5
- Pages
- 532-540
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC5856106
- OpenAlex
- W2619017063
- Cited by
- 258
- References
- 33
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 21 · 2023: 33 · 2022: 25 · 2021: 36 · 2020: 48 · 2019: 28 · 2018: 22 · 2017: 10 · 2014: 1 · 2013: 1
- FWCI
- 38.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UM1CA186107, UM1CA176726, R25CA098566)
- Centers for Disease Control and Prevention (R01OH009803)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- rotating night shift work, breast cancer risk, shift work, circadian rhythm disruption, nurses
- MeSH terms
- Adult, Breast Neoplasms, Circadian Rhythm, Female, Humans, Middle Aged, Nurses, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Work Schedule Tolerance, Multivariate Analysis, Proportional Hazards Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
