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Cited by 373

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial

Grau, M. V.·2003·CancerSpectrum Knowledge Environment
DOI 10.1093/jnci/djg110
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Abstract

BACKGROUND: Calcium and vitamin D both appear to have antineoplastic effects in the large bowel. Although these nutrients are inter-related metabolically in bone and in the normal intestine, their potential interactions in large-bowel carcinogenesis are not well understood. METHODS: We assessed independent and joint effects of calcium supplementation and vitamin D status on adenoma recurrence in 803 subjects in a multi-center, placebo-controlled randomized clinical trial of calcium supplementation for the prevention of colorectal adenoma recurrence. Serum levels of 25-hydroxy [25-(OH)] vitamin D and 1,25-dihydroxy [1,25-(OH)2] vitamin D levels were determined, and the Taq I and Fok I polymorphisms in the vitamin D receptor (VDR) gene were analyzed by polymerase chain reaction. Risk ratios (RRs) for any adenoma recurrence were computed for calcium supplementation within groups defined by serum vitamin D levels and for serum vitamin D levels within treatment groups. Associations of VDR polymorphisms with recurrence risk were also evaluated. All statistical tests were two-sided. RESULTS: Among subjects with baseline 25-(OH) vitamin D levels at or below the median (29.1 ng/mL), calcium supplementation was not associated with adenoma recurrence, whereas among those with levels above the median, calcium supplementation was associated with a reduced risk (RR = 0.71, 95 % confidence interval [CI] = 0.57 to 0.89, P for interaction =.012). Conversely, serum 25-(OH) vitamin D levels were associated with a reduced risk only among subjects receiving calcium supplements (RR per 12 ng/mL increase of vitamin D = 0.88, 95% CI = 0.77 to 0.99, P for interaction =.006). VDR polymorphisms were not related to adenoma recurrence and did not modify the associations with vitamin D or calcium. CONCLUSIONS: Calcium supplementation and vitamin D status appear to act largely together, not separately, to reduce the risk of colorectal adenoma recurrence. VDR genotype does not appear to be associated with risk.

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Metadata

Authors
Grau, M. V.
Venue
CancerSpectrum Knowledge Environment
Publisher
Oxford University Press (OUP)
Published
2003-12-03
Volume
95
Issue
23
Pages
1765-1771
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/djg110
OpenAlex
W2153523313
Cited by
373
References
38
FWCI
15.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial. https://app.cochat.ai/papers/10.1093/jnci/djg110
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Grau, M. V. (2003). Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial. CancerSpectrum Knowledge Environment. https://doi.org/10.1093/jnci/djg110

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