CoChat
Sign Up
Cited by 1,547

The DOI matches its Crossref record.

The WHO Classification of Tumors of the Nervous System

Kleihues, Paul, Louis, David N., Scheithauer, Bernd W., Rorke, Lucy B., Reifenberger, Guido, Burger, Peter C., Cavenee, Webster K.·2002·Journal of Neuropathology & Experimental Neurology
DOI 10.1093/jnen/61.3.215
Open this paper in CoChat — free account

Abstract

The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.

Overview

Integrity signals

Registry

Crossref · 10.1093/jnen/61.3.215

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 71

  1. Kleihues P Cavenee WK eds. World Health Organisation classification of tumours: Pathology and genetics of tumours of the nervous system. Lyon: IARC Press, 2000
  2. Kleihues P Burger PC Scheithauer BW eds. Histological typing of tumours of the central nervous system. World Health Organization international histological classification of tumours, 2nd Ed. Berlin, Heidelberg: Springer Verlag, 1993 · DOI
  3. 10.1111/j.1750-3639.1993.tb00752.x · DOI
  4. Hamilton SR Aaltonen LA eds. World Health Organisation classification of tumours: Pathology and genetics of tumours of the digestive system. Lyon, France: IARC Press, 2000
  5. Jaffe ES Harris NL Stein H Vardiman JW eds. World Health Organisation classification of tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press, 2001
  6. International classification of diseases for oncology Third Edition . Fritz A, Percy C, Jack A et al, eds. Geneva, Switzerland: World Health Organization, 2000
  7. Daumas-Duport, 1988, Grading of astrocytomas, A simple and reproducible method. Cancer, 62, 2152
  8. 10.1111/j.1750-3639.1993.tb00721.x · DOI
  9. 10.3171/jns.1994.81.3.0427 · DOI
  10. 10.1111/j.1750-3639.1996.tb00848.x · DOI
  11. 10.1177/019262330002800121 · DOI
  12. 10.1093/neuonc/1.1.44 · DOI
  13. Louis, 2001, Glioma classification: A molecular reappraisal, Am J Pathol, 59, 779, 10.1016/S0002-9440(10)61750-6 · DOI
  14. 10.1097/00005072-199901000-00006 · DOI
  15. 10.1001/archneur.56.4.434 · DOI
  16. 10.1093/jnci/90.19.1473 · DOI
  17. Smith, 2000, Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas, J Clin Oncol, 18, 636, 10.1200/JCO.2000.18.3.636 · DOI
  18. 10.1073/pnas.181340798 · DOI
  19. Reifenberger, 1994, Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p, Am J Pathol, 145, 1175
  20. 10.1097/00005072-199710000-00003 · DOI
  21. 10.3171/jns.2000.92.6.0983 · DOI
  22. Nelson, 1996, Glioblastoma with oligodendroglial features (GBM-OL): Report from Radiation Therapy Oncology Group (RTOG) trial 8302, Lab Invest, 74, 141A
  23. Kraus, 2001, Molecular genetic alterations in glioblastomas with oligodendroglial component, Acta Neuropathol (Berl), 101, 311, 10.1007/s004010000258 · DOI
  24. 10.3109/01913129709021312 · DOI
  25. 10.1002/path.1700440311 · DOI
  26. 10.1097/00005072-197803000-00001 · DOI
  27. 10.1055/s-2008-1053399 · DOI
  28. 10.1007/PL00007443 · DOI
  29. Corvi, 1995, Duplication of N-MYC at its resident site 2p24 may be a mechanism of activation alternative to amplification in human neuroblastoma cells, Cancer Res, 55, 3471
  30. 10.1097/00005072-199803000-00009 · DOI
  31. 10.1111/j.1750-3639.1999.tb00543.x · DOI
  32. 10.1097/00000478-200007000-00001 · DOI
  33. Taratuto AL Monges J Lylyk P Leiguarda R . Meningocerebral astrocytoma attached to dura with “desmoplastic” reaction. Proceedings of the IX International Congress of Neuropathology (Vienna), 1982
  34. VandenBerg, 1987, Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential (“desmoplastic infantile gangliogliomas”), Report on 11 cases of a distinctive embryonal tumor with favorable prognosis. J Neurosurg, 66, 58
  35. 10.1007/BF00690447 · DOI
  36. 10.1016/0046-8177(94)90309-3 · DOI
  37. 10.1097/00000478-199604000-00003 · DOI
  38. 10.1097/00000478-199606000-00002 · DOI
  39. 10.1097/00005072-198301000-00001 · DOI
  40. 10.1111/j.1750-3639.1997.tb01063.x · DOI
  41. Raffel, 1997, Sporadic medulloblastomas contain PTCH mutations, Cancer Res, 57, 842
  42. 10.1016/S0896-6273(00)80682-0 · DOI
  43. 10.1101/gad.14.8.994 · DOI · Paper page
  44. 10.1016/S0002-9440(10)64747-5 · DOI
  45. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1052>3.0.CO;2-S · DOI
  46. 10.1002/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO;2-G · DOI
  47. 10.1007/s003810050547 · DOI
  48. 10.1097/00000478-199207000-00007 · DOI
  49. 10.1159/000028932 · DOI
  50. 10.3171/jns.1996.85.1.0056 · DOI
  51. Biegel, 1999, Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors, Cancer Res, 59, 74
  52. Biegel, 2001, Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system, Clin Cancer Res, 6, 2759
  53. Perry, 1999, “Malignancy” in meningiomas: A clinicopathologic study of 116 patients, with grading implications, Cancer, 85, 2046
  54. 10.1097/00000478-199712000-00008 · DOI
  55. 10.1227/00006123-199207000-00002 · DOI
  56. 10.3171/jns.1992.77.4.0616 · DOI
  57. Rempel, 1993, Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression, Cancer Res, 53, 2386
  58. Simon, 1995, Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: A genetic model of meningioma progression, Cancer Res, 55, 4696
  59. 10.1073/pnas.94.26.14719 · DOI
  60. Emory, 1995, Intraneural perineurioma, A clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol, 103, 696
  61. 10.1097/00005537-199603000-00016 · DOI
  62. 10.1002/1097-0142(197805)41:5<1823::AID-CNCR2820410525>3.0.CO;2-J · DOI
  63. 10.1002/1097-0142(19920615)69:12<2917::AID-CNCR2820691209>3.0.CO;2-8 · DOI
  64. Val-Bernal, 1997, Renal perineurioma in childhood, Gen Diagn Pathol, 143, 75
  65. Giannini, 1997, Soft-tissue perineurioma, Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol, 21, 164
  66. 10.1097/00000478-199712000-00005 · DOI
  67. 10.1097/00000478-199810000-00002 · DOI
  68. 10.1097/00000478-199905000-00002 · DOI
  69. 10.1007/s004010100445 · DOI
  70. 10.1097/00000478-200106000-00008 · DOI
  71. 10.3171/jns.1999.91.6.0971 · DOI

Cited by

Sorted by citations

Metadata

Authors
Kleihues, P., Louis, D. N., Scheithauer, B. W., Rorke, L. B., Reifenberger, G., Burger, P. C., & Cavenee, W. K.
Venue
Journal of Neuropathology & Experimental Neurology
Publisher
Oxford University Press (OUP)
Published
2002-03
Volume
61
Issue
3
Pages
215-225
ISSN
  • 0022-3069
  • 1554-6578
DOI
10.1093/jnen/61.3.215
Cited by
1,547
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review