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Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline
Abstract
Sporadic, late-onset Alzheimer disease (AD) constitutes the most frequent cause of dementia in the elderly population. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis/lipohyalinosis (AS/LH). The present study was carried out to examine the coincidence of these small vessel pathologies during the development of cognitive deficits, amyloid beta-protein (A beta) deposition, and neurofibrillary tangle (NFT) formation in sporadic late-onset AD. We correlated the clinical dementia rating (CDR) score, the sequential extension of AD-related A beta deposition into different parts of the brain, and the extension of NFTs to involve more brain regions with the distribution of CAA and AS/LH in 52 human autopsy brains. The extension of CAA and AS/LH to involve different areas of the brain was associated with a rise of CDR scores and an increase in the extension of A beta deposition and NFT generation. AD cases showed a higher number of regions with CAA and AS/LH compared to nondemented patients with AD-related pathology and controls. Moreover, we demonstrated a hierarchical sequence in which the different regions of the brain exhibited CAA and AS/LH-affected vessels, allowing the distinction of 3 stages in the development of CAA and AS/LH. The first stage of CAA involved leptomeningeal and neocortical vessels. The second stage was characterized by additional A beta deposition in allocortical and midbrain vessels. Finally, in a third stage, CAA was observed in the basal ganglia, the thalamus, and in the lower brainstem. In contrast, AS/LH initially affected the basal ganglia in stage A. In stage B this pathology made inroads into the deep white matter, the leptomeningeal arteries of the cortex, the cerebellum, and into the thalamus. Stage C was characterized by AS/LH in brainstem vessels. Our results demonstrate widespread CAA and AS/LH to be associated with the development of cognitive deficits in AD. A combination of both CAA and AS/LH may, therefore, contribute to neurodegeneration in AD. These data also suggest that small vessel disease due to arteriosclerosis and fibrolipohyalinosis is a potential target for the treatment of AD.
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“Both CAA and CCA variants of VAβ pathology have been described in AD autopsies and their relative preponderance has been linked to various APOE genotypes [40–43].”
From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [41]
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Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
Self-citationProfound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
Apolipoprotein E genotyping by one-stage PCR
Wenham, P. R., Price, W. H., & Blundell, G. (1991) · The Lancet · doi:10.1016/0140-6736(91)92823-k · Cited by 1,070
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981
Research works printed but not linked: 4
- Esiri MM Hyman BT Beyreuther K . Ageing and dementia. In: Lantos PL , ed. Greenfields neuropathology, 6th Edition. London: Arnold, 1997:153–233
- Kim, 1988, Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide, Neurosci Res Commun, 2, 121
- Kalimo H Kaste M Haltia M . Vascular diseases. In: Lantos PL . Greenfield's neuropathology, 6th Edition. London: Arnold, 1997:315–96
- Roman, 1993, Vascular dementia: Diagnostic criteria for research studies, Report of the NINDS-AIREN International Workshop. Neurology, 43, 250
Cited by
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Items 301–384 of 384
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Attiah, I., Redha, L., & Ansari, S. A. (2024) · Aging and Health Research · doi:10.1016/j.ahr.2024.100194 · Cited by 3
Olofsson, H. E., Haglund, M., & Englund, E. M. (2023) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2023.100157 · Cited by 3
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Cho, E., Kang, M., & Kim, S. (2016) · Journal of the Korean Society of Radiology · doi:10.3348/jksr.2016.74.6.380 · Cited by 3
Comment on: Brain Microbleeds and Alzheimer’s Disease: Innocent Observation or Key Player?
Urbach, H. (2011) · Clinical Neuroradiology · doi:10.1007/s00062-011-0063-8 · Cited by 3
Nase, G., Helm, P. J., Oguchi, T., Nilsson, L. N. G., Lannfelt, L., Ottersen, O. P., & Torp, R. (2008) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.762739 · Cited by 3
Jiang, W., Kalsbeek, M. J. T., Corrêa‐da‐Silva, F., Jiao, H., Kalsbeek, A., Swaab, D. F., Siegelaar, S. E., & Yi, C. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02942-y · Cited by 2
Differential diagnosis and common pathology between Alzheimer’s disease and vascular dementia
Tomimoto, H. (2013) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.53.915 · Cited by 2
Retinal Screening for Early Detection of Alzheimer’s Disease
Frost, S. M., Martins, R. N., & Kanagasingam, Y. (2012) · Springer eBooks · doi:10.1007/978-3-642-25810-7_9 · Cited by 2
Carresi, C., Cardamone, A., Coppoletta, A. R., Mollace, A., Musolino, V., Gliozzi, M., & Mollace, V. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2023.1271005 · Cited by 2
The Neuropathology of the Dementing Disorders
McKee, A. C., & Gavett, B. E. (2011) · Wiley eBooks · doi:10.1002/9781444344110.ch7 · Cited by 2
Asaad, E., Schobert, J., Stubbe, K., Erdur, H., Hahn, K., & Kleine, J. F. (2025) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-025-01818-2 · Cited by 1
Ichimata, S., Yoshida, K., & Tanaka, R. (2025) · Brain Pathology · doi:10.1111/bpa.70051 · Cited by 1
Hayashi, H., Saito, R., Miyashita, A., Ikeuchi, T., Tada, M., Akazawa, K., Onodera, O., Tainaka, K., & Kakita, A. (2026) · Science Advances · doi:10.1126/sciadv.aea7539 · Cited by 1
Ururahy, R. D. R., Justo, A. F. O., Leite, R. E. P., Paes, V. R., Conforto, A. B., Grinberg, L. T., Pasqualucci, C. A., Ferriolli, E., & Suemoto, C. K. (2026) · Stroke · doi:10.1161/strokeaha.125.053151 · Cited by 2
Shafiei, N., Proniakova, D., Simjanoska, M., Sjødal, A. M. R., Stähli, D. A., van den Heuvel, L., Fabrizio, M. D., Aaron, E., Kasas, S., Krause, M. S., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03039-w · Cited by 3
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Liang, W., Cheung, D. W.-S., Tang, H. C., Lam, W. P., Zhang, L., Leung, P., & Yew, D. T.-W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00089-6 · Cited by 1
Healthy young hearts sharper older minds make
Knopman, D. S., & Roberts, R. O. (2013) · Annals of Neurology · doi:10.1002/ana.23847 · Cited by 1
Canine counterpart of senile dementia of the Alzheimer type
Rofina, J., Eerdenburg, F. J. C. M. V., & Gruys, E. (2007) · Utrecht University Repository (Utrecht University) · Cited by 1
The heterogeneity of vascular cognitive impairments and the issues of therapy
Катунина, Е. А. (2015) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2015-3-62-69 · Cited by 2
Cerebral hemorrhages in traumatic brain injury
Andrei Irimia, A., Rostowsky, K. A., Law, E. M., & Chui, H. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823347-4.00030-0 · Cited by 1
Windon, C., & Elahi, F. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-49963-0_30 · Cited by 1
Alzheimer-Associated Pathology in the Extracellular Space
Braak, H., & Tredici, K. D. (2014) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-12679-1_8 · Cited by 1
Roggendorf, W. (2011) · Springer eBooks · doi:10.1007/978-3-642-02324-8_10 · Cited by 2
Pagano, M. A., Laffue, A., Garau, M. L., Cousillas, J., Yorio, A., Amores, M., Krynski, F., & Fuente, G. V. (2015) · Neurología Argentina · doi:10.1016/j.neuarg.2014.10.005 · Cited by 1
Concept and classification of small vessel disease
Tomimoto, H. (2013) · Nosotchu · doi:10.3995/jstroke.35.128 · Cited by 1
Early MRI imaging and follow-up study in cerebral amyloid angiopathy
Zhang, S., Jia, J., Zhao, H., Zhou, B., Wang, W., Lu, X., Wang, H., Wang, Z., & Wu, W.-P. (2021) · Open Medicine · doi:10.1515/med-2021-0212 · Cited by 1
Neltner, J. H., & Nelson, P. T. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch1 · Cited by 1
Not All Lobar Hemorrhages Are Created Equal
Das, A. S., & Gurol, M. E. (2020) · Stroke · doi:10.1161/strokeaha.120.032404 · Cited by 1
DiFrancesco, J. C., & Stanzani, L. (2022) · Neurology · doi:10.1212/wnl.0000000000200166 · Cited by 1
Vascular Biomechanics and Brain Biochemistry in Aged and Alzheimer’s Disease Mouse ModelsPreprint
Jones, A., Jarrahi, A., Karpowich, K., Brown, L., Schulz, K. M., Prosser, R. A., & Crouch, A. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.27.645832 · Cited by 1
The Alzheimer disease continuum : findings from monogenic Alzheimer disease
Johansson, C. (2025) · doi:10.69622/28639856 · Cited by 3
Kinreich, S., Bingly, A., & Pandey, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.09.653177 · Cited by 1
Synapses, spines, zinc and pathology of Alzheimer's disease.
Familtsev, D. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/420 · Cited by 1
Charidimou, A. (2015) · UCL Discovery (University College London) · Cited by 1
Blutbasierte Mikrozirkulationsmarker bei der Alzheimer-Demenz
Knauer, K. (2010) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.12369
Deregulation of oxidative phosphorylation system and energy homeostasis in Alzheimer's disease
Rhein, V. F. (2009) · edoc (University of Basel) · doi:10.5451/unibas-005042311
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
Bjerke, M. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Current concepts and nomenclature harmonization
Grinberg, L. T. (2012)
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Davis, P. R. (2014) · UKnowledge (University of Kentucky)
Ocular biomarkers for early detection and monitoring of Alzheimer's disease
Frost, S. M. (2013) · UWA Profiles and Research Repository (UWA)
Roach, E. S., Bettermann, K., & Biller, J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781139644235.018
Alzheimer’s Disease—is it Caused by Cerebrovascular Dysfunction?
Humpel, C. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326697.003.0015
Microglia and Complement in Alzheimer's Disease with Cerebral Amyloid Angiopathy
Zabel, M. K. (2013) · The Scholars Repository - LLU (Loma Linda University)
Kaye, E. D. (2011) · TSpace (University of Toronto)
Present status and future perspectives for vascular cognitive impairment
Tomimoto, H. (2015) · Nosotchu · doi:10.3995/jstroke.10303
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Ighodaro, E. T. (2018) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2018.049
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Attems, J., McAleese, K. E., & Walker, L. (2018) · Neuromethods · doi:10.1007/978-1-4939-7674-4_5
Reuck, J. D., & Degenerative and Vascular Cognitive Disorders, U. D. L. 2. (2018) · European Neurological Review · doi:10.17925/enr.2018.13.2.100
Preventing cognitive decline through resistance training
Marston, K. J. (2019) · Murdoch University Research Portal
Thal, D. R., & Braak, H. (2005) · Der Pathologe
Self-citationVascular Disorders: Angiopathies
Weis, S., Sonnberger, M., Dunzinger, A., Voglmayr, E., Aichholzer, M., Kleiser, R., & Strasser, P. (2019) · Springer eBooks · doi:10.1007/978-3-7091-1544-2_23
Mitochondrial Aspects of Neuronal Pathology in Triple-Transgenic Alzheimer’s Disease Mice
Cavendish, J. Z. (2019) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.4024
Kunst, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44549-8.00004-3
Russell, A. E. (2019) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.3947
自己組織化単分子膜を用いた有機不揮発性メモリの作製と閾値制御(センサ,デバイス,一般)
中川, 隆., 横田, 知., 関谷, 毅., 竹内, 健., 染谷, 隆., & Klauk, H. (2010) · 電子情報通信学会技術研究報告. OME, 有機エレクトロニクス
Studies on the use of glycosaminoglycans for the treatment of Alzheimer's Disease
Cui, H. (2012) · UTAS Research Repository · doi:10.25959/23206211
Current awareness in geriatric psychiatry
(2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1065
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(2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1064
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Rohde, S. K., Fierro‐Hernández, P., Rozemüller, A. J. M., Bank, N. B., Lorenz, L. M. C., Zhang, M., Graat, M., van der Hoorn, M. E., Daatselaar, D., Hulsman, M., et al. (2023) · medRxiv · doi:10.1101/2023.12.28.23300604
Hayashi, H., Saito, R., Miyashita, A., Ikeuchi, T., Tada, M., Akazawa, K., Onodera, O., Tainaka, K., & Kakita, A. (2024) · Research Square · doi:10.21203/rs.3.rs-5084154/v1
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Lloyd, G. M., Trejo‐Lopez, J. A., Xia, Y., McFarland, K. N., Lincoln, S., Ertekin-Taner, N., Giasson, B. I., Yachnis, A. T., & Prokop, S. (2020) · Figshare · doi:10.6084/m9.figshare.11978586
Lloyd, G. M., Trejo‐Lopez, J. A., Xia, Y., McFarland, K. N., Lincoln, S., Ertekin-Taner, N., Giasson, B. I., Yachnis, A. T., & Prokop, S. (2020) · Figshare · doi:10.6084/m9.figshare.11978577
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Jones, A. W., Jarrahi, A., Karpowich, K., Brown, L. P., Schulz, K. M., Prosser, R. A., & Crouch, A. C. (2026) · eNeuro · doi:10.1523/eneuro.0293-25.2025 · Cited by 1
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Schrader, J. M., Agostinucci, K. J., Davis, J., Xu, F., Hunter, D., & Nostrand, W. E. V. (2026) · Targets · doi:10.3390/targets4020020
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Chaachou-Charradi, A., Burgueño‐García, I., Camacho, J., Moliné, T., Zagrean, N., y Cajal, S. R., Rábano‐Gutierrez, A., Martínez-Sáez, E. A., & Hernández‐Guillamón, M. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71786
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Metadata
- Authors
- Thal, D. R., Ghebremedhin, E., Orantes, M., & Wiestler, O. D.
- Affiliations
- University of Bonn (DE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Thal, Dietmar Rudolf
- ORCID
- Thal, Dietmar Rudolf
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12
- Volume
- 62
- Issue
- 12
- Pages
- 1287-1301
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W1603244154
- Cited by
- 384
- References
- 51
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 14 · 2023: 14 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 22 · 2014: 23 · 2013: 21 · 2012: 11
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (TH624 4–1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- Alzheimer's disease, cerebral amyloid angiopathy, arteriosclerosis, lipohyalinosis, cerebral small vessel disease, cognitive decline, amyloid-beta deposition, neurofibrillary tangles, disease staging, vascular pathology, dementia, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Intracranial Arteriosclerosis, Cognition Disorders, Female, Humans, Male, Middle Aged, Cerebral Amyloid Angiopathy
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