Cited by 384Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchIntracerebral and Subarachnoid Hemorrhage Research

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline

Thal, Dietmar Rudolf, Ghebremedhin, Estifanos, Orantes, Mario, Wiestler, Otmar D.·2003·Journal of Neuropathology & Experimental Neurology

DOI 10.1093/jnen/62.12.1287

Open this paper in CoChat — free account

Abstract

Sporadic, late-onset Alzheimer disease (AD) constitutes the most frequent cause of dementia in the elderly population. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis/lipohyalinosis (AS/LH). The present study was carried out to examine the coincidence of these small vessel pathologies during the development of cognitive deficits, amyloid beta-protein (A beta) deposition, and neurofibrillary tangle (NFT) formation in sporadic late-onset AD. We correlated the clinical dementia rating (CDR) score, the sequential extension of AD-related A beta deposition into different parts of the brain, and the extension of NFTs to involve more brain regions with the distribution of CAA and AS/LH in 52 human autopsy brains. The extension of CAA and AS/LH to involve different areas of the brain was associated with a rise of CDR scores and an increase in the extension of A beta deposition and NFT generation. AD cases showed a higher number of regions with CAA and AS/LH compared to nondemented patients with AD-related pathology and controls. Moreover, we demonstrated a hierarchical sequence in which the different regions of the brain exhibited CAA and AS/LH-affected vessels, allowing the distinction of 3 stages in the development of CAA and AS/LH. The first stage of CAA involved leptomeningeal and neocortical vessels. The second stage was characterized by additional A beta deposition in allocortical and midbrain vessels. Finally, in a third stage, CAA was observed in the basal ganglia, the thalamus, and in the lower brainstem. In contrast, AS/LH initially affected the basal ganglia in stage A. In stage B this pathology made inroads into the deep white matter, the leptomeningeal arteries of the cortex, the cerebellum, and into the thalamus. Stage C was characterized by AS/LH in brainstem vessels. Our results demonstrate widespread CAA and AS/LH to be associated with the development of cognitive deficits in AD. A combination of both CAA and AS/LH may, therefore, contribute to neurodegeneration in AD. These data also suggest that small vessel disease due to arteriosclerosis and fibrolipohyalinosis is a potential target for the treatment of AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jnen/62.12.1287

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
Self-citation
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
Apolipoprotein E genotyping by one-stage PCR
Wenham, P. R., Price, W. H., & Blundell, G. (1991) · The Lancet · doi:10.1016/0140-6736(91)92823-k · Cited by 1,070
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981

Show all 51 references

Research works printed but not linked: 4

Esiri MM Hyman BT Beyreuther K . Ageing and dementia. In: Lantos PL , ed. Greenfields neuropathology, 6th Edition. London: Arnold, 1997:153–233
Kim, 1988, Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide, Neurosci Res Commun, 2, 121
Kalimo H Kaste M Haltia M . Vascular diseases. In: Lantos PL . Greenfield's neuropathology, 6th Edition. London: Arnold, 1997:315–96
Roman, 1993, Vascular dementia: Diagnostic criteria for research studies, Report of the NINDS-AIREN International Workshop. Neurology, 43, 250

Sorted by citations

Items 201–300 of 384

Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes)
de la Monte, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230555 · Cited by 28
Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells
Previti, M. L., Zhang, W., & Nostrand, W. E. V. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-18 · Cited by 27
The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type
Pluta, R. M., Czuczwar, S. J., Januszewski, S., & Jabłoński, M. (2021) · Cells · doi:10.3390/cells10092213 · Cited by 24
Genomic characterization of Alzheimer’s disease and genotype-related phenotypic analysis of biological markers in dementia
Cacabelos, R. (2004) · Pharmacogenomics · doi:10.1517/14622416.5.8.1049 · Cited by 27
Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
Thal, D. R., Ronisz, A., Tousseyn, T., Upadhaya, A. R., Balakrishnan, K., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Otto, M., Beach, T. G., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01005-5 · Cited by 25
Self-citation
Clinical-radiological presentation and natural history of iatrogenic cerebral amyloid angiopathy
Fandler‐Höfler, S., Kaushik, K., Storti, B., Pikija, S., Mallon, D. H., Ambler, G., Damavandi, P. T., Panteleienko, L., Canavero, I., van Walderveen, M. A. A., et al. (2025) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-335164 · Cited by 28
Patterns of Mixed Pathologies in Down Syndrome
Ichimata, S., Yoshida, K., Visanji, N. P., Lang, A. E., Nishida, N., & Kovacs, G. G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215675 · Cited by 24
Alzheimer’s Silent Partner: Cerebral Amyloid Angiopathy
Cupino, T. L., & Zabel, M. K. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0309-7 · Cited by 27
ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults
Shinto, L. H., Murchison, C., Silbert, L. C., Dodge, H. H., Lahna, D. L., Rooney, W. D., Kaye, J. A., Quinn, J. F., & Bowman, G. L. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.26872 · Cited by 23
Distinct Brain Proteomic Signatures in Cerebral Small Vessel Disease Rat Models of Hypertension and Cerebral Amyloid Angiopathy
Schrader, J. M., Stanisavljevic, A., Xu, F., & Nostrand, W. E. V. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac057 · Cited by 27
Brain and spinal cord arteriolosclerosis and its associations with cerebrovascular disease risk factors in community-dwelling older adults
Oveisgharan, S., Kim, N., Agrawal, S., Yu, L., Leurgans, S. E., Kapasi, A., Arfanakis, K., Bennett, D. A., Schneider, J. A., & Buchman, A. S. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02527-z · Cited by 26
Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter
McAleese, K. E., Firbank, M., Hunter, D., Sun, L., Hall, R., Neal, J., Mann, D. M. A., Esiri, M. M., Jellinger, K. A., O'Brien, J. T., et al. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01310.x · Cited by 24
Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease
Lloyd, G. M., Trejo‐Lopez, J. A., Xia, Y., McFarland, K. N., Lincoln, S., Ertekin‐Taner, N., Giasson, B. I., Yachnis, A. T., & Prokop, S. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-0891-3 · Cited by 24
Different clinical outcomes between cerebral amyloid angiopathy-related inflammation and non-inflammatory form
Grangeon, L., Quesney, G., Verdalle-Cazes, M., Coulette, S., Renard, D., Wacongne, A., Allou, T., Olivier, N., Boukriche, Y., Blanchet-Fourcade, G., et al. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11145-4 · Cited by 23
Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease
Biffi, A., Sabuncu, M. R., Desikan, R. S., Schmansky, N., Salat, D. H., Rosand, J. M., & Anderson, C. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.141 · Cited by 23
Advancements and Challenges in Antiamyloid Therapy for Alzheimer’s Disease: A Comprehensive Review
Beshir, S. A., Hussain, N., Menon, V. B., Haddad, A. H. I. A., Zeer, R. A. K. A., & Elnour, A. A. (2024) · International Journal of Alzheimer s Disease · doi:10.1155/2024/2052142 · Cited by 32
Vascular Dysfunction Is Central to Alzheimer’s Disease Pathogenesis in APOE e4 Carriers
McCorkindale, A. N., Mundell, H. D., Guennewig, B., & Sutherland, G. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137106 · Cited by 23
Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions
Sheikh, A. M., Yano, S., Tabassum, S., Mitaki, S., Michikawa, M., & Nagai, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054510 · Cited by 23
The clinical importance of suspected non-Alzheimer disease pathophysiology
Vos, S. J. B., Delvenne, A., Jack, C. R., Thal, D. R., & Visser, P. J. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00962-y · Cited by 23
Self-citation
Dementia
Taylor, M. E., & Close, J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63916-5.00019-7 · Cited by 26
Relative paucity of tau accumulation in the small areas with abundant Aβ42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology
Oshima, K., Akiyama, H., Tsuchiya, K., Kondo, H., Haga, C., Shimomura, Y., Iseki, E., Uchikado, H., Kato, M., Niizato, K., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0070-z · Cited by 22
Amyloid-Beta Pathology and Cognitive Performance in Centenarians
Rohde, S. K., Luimes, M. C., Lorenz, L. M. C., Fierro‐Hernández, P., Rozemüller, A. J. M., Hulsman, M., Zhang, M., Graat, M., van der Hoorn, M. E., Daatselaar, D., et al. (2025) · JAMA Neurology · doi:10.1001/jamaneurol.2025.1734 · Cited by 26
Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy
Ojo, J. O., Reed, J. M., Crynen, G. C., Vallabhaneni, P., Evans, J., Shackleton, B., Eisenbaum, M., Ringland, C., Edsell, A., MULLAN, M. J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.658605 · Cited by 22
Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer’s Disease
Kamara, D. M., Gangishetti, U., Gearing, M., Willis‐Parker, M., Zhao, L., Hu, W. T., & Walker, L. C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170954 · Cited by 22
The Contribution of Cerebral Vascular Neuropathology to Mild Stage of Alzheimer’s Dementia Using the NACC Database
Liu, Y., Chan, D. K. Y., Crawford, J. D., Sachdev, P. S., & Braidy, N. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210212160902 · Cited by 23
Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage
Pasi, M., Charidimou, A., Boulouis, G., Fotiadis, P., Morotti, A., Xiong, L., Marini, S., Ayres, A. M., Frosch, M. P., Goldstein, J. N., et al. (2019) · Journal of Neurology · doi:10.1007/s00415-018-09177-w · Cited by 20
Neurodegenerative Diseases and Ageing
Walker, L., McAleese, K. E., Erskine, D., & Attems, J. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_4 · Cited by 21
Cortical microinfarcts in patients with multiple lobar microbleeds on 3 T MRI
Ii, Y., Maeda, M., Ishikawa, H., Ito, A., Matsuo, K., Umino, M., Shindo, A., Kida, H., Satoh, M., Niwa, A., et al. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09350-9 · Cited by 21
Hypertensive Arteriopathy and Cerebral Amyloid Angiopathy in Patients with Cognitive Decline and Mixed Cerebral Microbleeds
Ii, Y., Ishikawa, H., Matsuyama, H., Shindo, A., Matsuura, K., Yoshimaru, K., Satoh, M., Taniguchi, A., Matsuda, K., Umino, M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200992 · Cited by 20
Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy
Shirzadi, Z., Yau, W. W., Schultz, S. A., Schultz, A. P., Scott, M. R., Goubran, M., Forooshani, P. M., Joseph‐Mathurin, N., Kantarci, K., Preboske, G. M., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26429 · Cited by 18
Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Diabetes Mellitus
Roeben, B., the TREND study team, Maetzler, W., Vanmechelen, E., Schulte, C., Heinzel, S., Stellos, K., Godau, J., Huber, H., Brockmann, K., et al. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150575 · Cited by 19
Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis
Krämer, L. M., Brettschneider, J., Lennerz, J. K., Walcher, D., Fang, L., Rosenbohm, A., Balakrishnan, K., Benckendorff, J., Möller, P., Just, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34808-7 · Cited by 19
Self-citation
Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease
Wang, L., Liu, Q., Yue, D., Liu, J., & Fu, Y. (2024) · Journal of Stroke · doi:10.5853/jos.2023.01942 · Cited by 20
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Catak, C., Zedde, M., Malik, R., Janowitz, D., Soric, V., Seegerer, A., Krebs, A., Duering, M., Opherk, C., Linn, J., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00439 · Cited by 18
Distinct brain regional proteome changes in the rTg‐DI rat model of cerebral amyloid angiopathy
Schrader, J. M., Xu, F., & Nostrand, W. E. V. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15463 · Cited by 18
Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults
Dawe, R. J., Yu, L., Schneider, J. A., Arfanakis, K., Bennett, D. A., & Boyle, P. A. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.020 · Cited by 17
Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection
Marsillach, J., Parra, S., Ferré, N., Coll, B., Alonso‐Villaverde, C., Joven, J., & Camps, J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6561-3_12 · Cited by 18
Moderate loss of cerebellar Purkinje cells after chronic bilateral common carotid artery occlusion in rats
Kántor, O., Schmitz, C., Feiser, J., Brasnjevic, I., Korr, H., Busto, R., Ginsberg, M. D., & Schmidt‐Kastner, R. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0204-y · Cited by 18
Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model
Reinitz, F., Chen, E. Y., Nicolis di Robilant, B., Chuluun, B., Antony, J., Jones, R. C., Gubbi, N., Lee, K., Ho, W. H. D., Kolluru, S. S., et al. (2022) · eLife · doi:10.7554/elife.66037 · Cited by 18
Chronic cerebral hypoperfusion and dementia
Yata, K., & Tomimoto, H. (2014) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.124 · Cited by 17
Neuropathologic Findings in Chronic Kidney Disease (CKD)
Vinters, H. V., Magaki, S., & Williams, C. K. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105657 · Cited by 17
Could changes in arterioles impede the perivascular drainage of interstitial fluid from the cerebral white matter in leukoaraiosis?
Huang, Y., ZHANG, W., Lin, L., Feng, J., Zhao, X. X., Guo, W. H., & Wei, W. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01049.x · Cited by 16
Multiple system aging‐related tau astrogliopathy with complex proteinopathy in an oligosymptomatic octogenarian
Klotz, S., Fischer, P. A., Hinterberger, M., Ricken, G., Hönigschnabl, S., Gelpí, E., & Kovács, G. G. (2020) · Neuropathology · doi:10.1111/neup.12708 · Cited by 15
Widespread severe cerebral elevations of haptoglobin and haemopexin in sporadic Alzheimer’s disease: Evidence for a pervasive microvasculopathy
Philbert, S. A., Xu, J., Unwin, R. D., Dowsey, A. W., & Cooper, G. J. S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.107 · Cited by 15
Starvation triggers Aβ42 generation from human umbilical vascular endothelial cells
Ma, J., Wang, H., Li, Q., Zhang, Y., Pan, J., Qiang, Q., Xin, X., Tang, H., Ding, J., & Chen, S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.048 · Cited by 15
Cerebral amyloid angiopathy initially occurs in the meningeal vessels
Takeda, S., Yamazaki, K., Miyakawa, T., & Onda, K. (2017) · Neuropathology · doi:10.1111/neup.12403 · Cited by 14
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)
Kállai, A., Ungvari, A., Csabán, D., Őrfi, Z., Lehoczki, A., Harasztdombi, J., Yabluchanskiy, A., Benyó, Z., Szappanos, Á., Tarantini, S., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01654-1 · Cited by 14
Cerebellar hemorrhages in patients with cerebral amyloid angiopathy
Gavriliuc, P., Molad, J., Yaghmour, N. E., Honig, A., Gomori, J. M., Cohen, J. E., Auriel, E., & Leker, R. R. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.08.003 · Cited by 14
Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum
Taghvaei, M., Dolui, S., Sadaghiani, S., Shakibajahromi, B., Brown, C. D., Khandelwal, P., Xie, S. X., Das, S. R., Yushkevich, P. A., Wolk, D. A., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14382 · Cited by 15
Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na+/K+-ATPase Dysfunction in Vascular Dementia
Philbert, S. A., Xu, J., Scholefield, M., Church, S. J., Unwin, R. D., & Cooper, G. J. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.822787 · Cited by 13
Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly
Kang, S.-J., Park, B., Shim, J., Lee, H.-R., Hong, J., & Lee, Y. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.10.010 · Cited by 13
Hereditary and sporadic beta-amyloidoses
Fede, G. D. (2013) · Frontiers in bioscience · doi:10.2741/4173 · Cited by 13
Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease
Shirzadi, Z., Schultz, A. P., Properzi, M. J., Yaari, R., Yau, W.-Y. W., Brickman, A. M., Rafii, M. S., Donohue, M., Ernstrom, K. B., Wang, S., et al. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.139 · Cited by 13
Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment
Jang, H., Park, J.-Y., Jang, Y. K., Kim, H. J., Lee, J. S., Na, D. L., Noh, Y., Lockhart, S. N., Seong, J., & Seo, S. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-34032-3 · Cited by 12
Maladie d'Alzheimer : prendre en compte les facteurs de risque et pathologies cardiovasculaires
Antoine, V., & Rigaud, A. (2005) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2005.04.037 · Cited by 11
Pathology-based brain arterial disease phenotypes and their radiographic correlates
Gutierrez, J., Bos, D., Turan, T. N., Hoh, B. L., Hilal, S., Arenillas, J. F., Schneider, J. A., Chimowitz, M. I., & Morgello, S. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107642 · Cited by 11
Background and distribution of lobar microbleeds in cognitive dysfunction
Matsuyama, H., Ii, Y., Maeda, M., Umino, M., Ueda, Y., Tabei, K., Kida, H., Satoh, M., Shindo, A., Taniguchi, A., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.856 · Cited by 11
The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study
Meyronet, D., Dorey, A., Massoma, P., Rey, C., Alix, E., Silva, K., Perrin, C., Quadrio, I., Perret‐Liaudet, A., Streichenberger, N., et al. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1378-4 · Cited by 11
Antihypertensives, angiotensin, glucose and Alzheimer’s disease
Nelson, L., Tabet, N., Richardson, C., & Gard, P. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.32 · Cited by 11
Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
Schrader, J. M., Xu, F., Agostinucci, K. J., DaSilva, N. A., & Nostrand, W. E. V. (2024) · Scientific Reports · doi:10.1038/s41598-024-59013-7 · Cited by 11
Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy
Snorradóttir, Á. Ó., Ísaksson, H. J., Kaeser, S. A., Skodras, A., Ólafsson, E., Pálsdóttir, Á., & Bragason, B. Þ. (2015) · Brain Research · doi:10.1016/j.brainres.2015.06.019 · Cited by 12
Pathology of cerebral small vessel disease
Ogata, J., Yamanishi, H., & Ishibashi‐Ueda, H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139382694.003 · Cited by 11
Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
Vargas-George, S. A., & Dave, K. R. (2022) · Brain Hemorrhages · doi:10.1016/j.hest.2022.05.001 · Cited by 10
Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy
Platholi, J., Marongiu, R., Park, L., Yu, F., Sommer, G., Weinberger, R., Tower, W., Milner, T. A., & Glass, M. J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1280218 · Cited by 9
Tissue Transglutaminase: A Novel Therapeutic Target in Cerebral Amyloid Angiopathy
Wilhelmus, M. M. M., de Jager, M., & Drukarch, B. (2011) · Neurodegenerative Diseases · doi:10.1159/000333224 · Cited by 9
Quantitative histomorphometry of capillary microstructure in deep white matter
Mozumder, M., Pozo, J. M., Coelho, S., Costantini, M., Simpson, J. E., Highley, J. R., Ince, P. G., & Frangi, A. F. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101839 · Cited by 10
Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey
Chan, A. W. S., Cho, I. K., Li, C., Zhang, X., Patel, S., Rusnak, R., Raper, J., Bachevalier, J., Moran, S. P., Chi, T., et al. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100044 · Cited by 10
Post-Stroke Cognitive Impairment
Patel, B. B., & Birns, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-17855-4_12 · Cited by 9
Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt–Jakob disease
Eurelings, L. S. M., Richard, E., Carrano, A., Eikelenboom, P., van Gool, W. A., & Rozemüller, A. J. M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.04.020 · Cited by 9
Cerebral Amyloid Angiopathy: Clinical Presentation, Sequelae and Neuroimaging Features—An Update
Weidauer, S., & Hattingen, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030603 · Cited by 11
Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood‐Based Biomarkers
Gunasekaran, T. I., Sanchez, D. L., Reyes‐Dumeyer, D., Ventura, R., Morales, C. D., Alshikho, M. J., Lee, A., Lantigua, R., Gu, Y., Honig, L. S., et al. (2025) · Annals of Neurology · doi:10.1002/ana.70006 · Cited by 8
Polyphenol-Peptide Interactions in Mitigation of Alzheimer’s Disease: Role of Biosurface-Induced Aggregation
Gaudreault, R., Hervé, V., van de Ven, T. G. M., Mousseau, N., & Ramassamy, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201549 · Cited by 8
Prediction of amyloid β PET positivity using machine learning in patients with suspected cerebral amyloid angiopathy markers
Jung, Y. H., Lee, H., Kim, H. J., Na, D. L., Han, H. J., Jang, H., & Seo, S. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-75664-8 · Cited by 8
Human Alzheimer's Disease ATN/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI‐Based Regional Gray Matter Volume
Barnes, C. A., Permenter, M. R., Vogt, J. A., Chen, K., & Beach, T. G. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25670 · Cited by 8
A comparison of cerebral amyloid angiopathy in the cerebellum and CAA ‐positive occipital lobe of 60 brains from routine autopsies
Okamoto, K., Amari, M., Ikeda, M., Fukuda, T., Suzuki, K., & Takatama, M. (2022) · Neuropathology · doi:10.1111/neup.12838 · Cited by 7
Vascular dementia: current concepts and nomenclature harmonization
Grinberg, L. T. (2012) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642012dn06030002 · Cited by 7
The incidence of cerebral amyloid angiopathy in surgically treated intracranial hemorrhage in the Chinese population
Tang, Y., Li, Y., Wang, S., Zhu, M., Sun, Y., & Zhao, J.-Z. (2013) · Neurosurgical Review · doi:10.1007/s10143-013-0474-x · Cited by 7
MRI of Vascular Dementia and Differential Diagnoses
Urbach, H., Tschampa, H. J., Flacke, S., & Thal, D. R. (2007) · Clinical Neuroradiology · doi:10.1007/s00062-007-7009-1 · Cited by 8
Self-citation
Severe pathological manifestation of cerebral amyloid angiopathy correlates with poor outcome from cerebral amyloid angiopathy related intracranial hemorrhage
Tang, Y., Wang, S., Zhu, M., Yi-lin, S., & Ji-zong, Z. H. A. O. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20122106 · Cited by 7
A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson’s disease with dementia
Fanciulli, A., Leys, F., Lehner, F., Sidoroff, V., Ruf, V., Raccagni, C., Mahlknecht, P., Kuipers, D. J. S., van IJcken, W. F. J., Stockner, H., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac175 · Cited by 7
Cerebral amyloid angiopathy: A clinicopathological study of three cases
Panicker, J., Nagaraja, D., & Chickabasaviah, Y. (2010) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.70879 · Cited by 7
Hypertension and late-life dementia
Knopman, D. S. (2009) · Neurology · doi:10.1212/01.wnl.0000345882.69564.f7 · Cited by 7
Distinct cerebral amyloid angiopathy patterns in adult Down syndrome
Szalárdy, L., Lee, S., Kim, A., & Kovács, G. G. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123601 · Cited by 6
Distinct cerebrovascular pathways underlying Alzheimer’s disease-related neurodegeneration
Mohanty, R., Wheatley, S., Chiotis, K., Marseglia, A., Westman, E., & Initiative, A. D. N. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02970-8 · Cited by 7
Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China
Yin, X., Sun, J., Wang, X., Wu, W., Chen, Z., Zhang, D., Xu, Y., Chen, Y., Qiu, W., Qian, X., et al. (2025) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70100 · Cited by 6
Deep cerebral microbleeds are associated with poor cholinesterase inhibitor treatment response in people with Alzheimer disease
Chiu, W. T., Lee, T. Y., Chan, L., Wu, D., Huang, L. K., Chen, D. Y. T., Lee, Y. T., Hu, C. J., & Hong, C. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105959 · Cited by 6
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex
Whinnery, C. D., Nie, Y., Boskovic, D. S., Soriano, S., & Kirsch, W. M. (2024) · Brain Sciences · doi:10.3390/brainsci14060601 · Cited by 6
Targeting Hypertension to Manage Alzheimer’s Disease: Rational and Promise
Cifuentes, D., & Pasteur Rousseau, A. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000228 · Cited by 4
Underlying microangiopathy and functional outcome of simultaneous multiple intracerebral hemorrhage
Li, J., Shen, D., Zhou, Y., Jin, Y., Jin, L., Ye, X., Tong, L., & Gao, F. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1000573 · Cited by 5
Original article The association between cerebral amyloid angiopathy and atherosclerosis in patients with intracerebral hemorrhages
Mendel, T. A., Wierzba‐Bobrowicz, T., Stępień, T., & Szpak, G. M. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.37709 · Cited by 5
The standardization of cerebrospinal fluid markers and neuropathological diagnoses brings to light the frequent complexity of concomitant pathology in Alzheimer's disease: The next challenge for biochemical markers?
Fenouil, T., Fourier, A., Quadrio, I., Streichenberger, N., Bernardini, S., Zima, T., Perret‐Liaudet, A., & Meyronet, D. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.06.004 · Cited by 5
CBF regulation in hypertension and Alzheimer’s disease
Yazdani, N., Kindy, M. S., & Taheri, S. (2020) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2020.1764014 · Cited by 6
Microalbuminurea as an index of brain microvascular dysfunction
WOLFSON, L. I. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.04.028 · Cited by 5
Classification, pathology, and basic aspects
Pantoni, L., & Gorelick, P. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139382694.002 · Cited by 5
Vascular neuropathology and cognitive decline
Deramecourt, V. (2013) · Revue Neurologique · doi:10.1016/j.neurol.2013.07.008 · Cited by 5
Amyloid‐β plaques may be reduced in advanced stages of cerebral amyloid angiopathy in the elderly
Okamoto, K., Amari, M., Fukuda, T., Suzuki, K., & Takatama, M. (2020) · Neuropathology · doi:10.1111/neup.12662 · Cited by 4
AD‐related plasma biomarkers in centenarians: links to cognition and neuropathology
Lorenz, L. M. C., Rohde, S. K., Luimes, M. C., Rozemüller, A. J. M., Bank, N. B., Hulsman, M., Graat, M. J. I., van der Hoorn, M. E., Daatselaar, D. A. H., Gouda, M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70969 · Cited by 4
Higher cerebellum florbetapir uptake in cerebral amyloid angiopathy compared to Alzheimer's disease: A dual florbetapir and FDG PET study
Sha, Y., Jia, C., Liang, M., Wu, J., Zhang, T., Zhu, Y., Yuan, J., Li, Q., Huang, Z., Ruixue, C., et al. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251409418 · Cited by 3
Animal Models of Vascular Dementia: Translational Potential At the Present Time and In 2050
Tomimoto, H., & Wakita, H. (2014) · Future Neurology · doi:10.2217/fnl.13.71 · Cited by 3
Superficial small cerebellar infarcts in cerebral amyloid angiopathy on 3 T MRI: A preliminary study
Ii, Y., Ishikawa, H., Nishigaki, A., Utsunomiya, T., Nakamura, N., Hirata, Y., Matsuyama, H., Kajikawa, H., Matsuura, K., Matsuda, K., et al. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.122975 · Cited by 3

Authors: Thal, D. R., Ghebremedhin, E., Orantes, M., & Wiestler, O. D.
Affiliations: University of Bonn (DE)
Goethe University Frankfurt (DE)
Corresponding author: Thal, Dietmar Rudolf
ORCID: Thal, Dietmar Rudolf
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2003-12
Volume: 62
Issue: 12
Pages: 1287-1301
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1093/jnen/62.12.1287
OpenAlex: W1603244154
Cited by: 384
References: 51
Citations by year: 2026: 11 · 2025: 19 · 2024: 14 · 2023: 14 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 22 · 2014: 23 · 2013: 21 · 2012: 11
FWCI: 5.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (TH624 4–1)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Keywords: Alzheimer's disease, cerebral amyloid angiopathy, arteriosclerosis, lipohyalinosis, cerebral small vessel disease, cognitive decline, amyloid-beta deposition, neurofibrillary tangles, disease staging, vascular pathology, dementia, neurodegeneration
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Intracranial Arteriosclerosis, Cognition Disorders, Female, Humans, Male, Middle Aged, Cerebral Amyloid Angiopathy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks