The DOI matches its Crossref record; 267 of the 267 references it cites were found in a registry or an index.
The Choroid Plexus in Healthy and Diseased Brain
Abstract
The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells produce the cerebrospinal fluid (CSF), which has many functions including rendering mechanical support, providing a route for some nutrients, removing by-products of metabolism and synaptic activity, and playing a role in hormonal signaling. The choroid plexus synthesizes many growth factors, including insulin-like, fibroblast, and platelet-derived growth factors. The tight junctions located between the apical parts of the choroid plexus epithelial cells form the blood-CSF barrier (BCSFB), which is crucial for the homeostatic regulation of the brain microenvironment along with the blood-brain barrier (BBB). Morphological changes such as atrophy of the epithelial cells and thickening of the basement membrane suggest altered CSF production occurs in aging and in Alzheimer disease. In brain injuries and infections, leukocytes accumulate in the CSF by passing through the choroid plexus. In inflammatory CNS diseases (eg, multiple sclerosis), pathogenic autoreactive T lymphocytes may migrate through the BBB and BCSFB into the CNS. The development of therapeutic strategies to mitigate disruption of the BCSFB may be helpful to curtail the entry of inflammatory cells into the CSF and hence reduce inflammation, thereby overcoming choroid plexus dysfunction in senescence and in various diseases of the CNS.
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“This molecularly driven invasion allows GBS to cross the BBB directly, again preceding the development of a massive inflammatory infiltrate that would be reflected as pleocytosis in the CSF (18).”
From Pathogen detection in acellular cerebrospinal fluid: diagnostic insights from a pediatric cohort in Colombia (2026) · cites this paper as [18]
In the citing paper
“Blood vessels within these two structures have endothelia that lack tight junctions and are open to peripheral circulation (25, 26).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [26]
Citations
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Cited by
Sorted by citations
The anatomy and immunology of vasculature in the central nervous system
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“This molecularly driven invasion allows GBS to cross the BBB directly, again preceding the development of a massive inflammatory infiltrate that would be reflected as pleocytosis in the CSF (18).”
Metadata
- Authors
- Kaur, C., Rathnasamy, G., & Ling, E.-A.
- Affiliations
- National University of Singapore (SG)
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-17
- Volume
- 75
- Issue
- 3
- Pages
- 198-213
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2281330516
- Cited by
- 176
- References
- 267
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 21 · 2023: 14 · 2022: 21 · 2021: 27 · 2020: 14 · 2019: 22 · 2018: 5 · 2017: 11 · 2016: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- choroid plexus, cerebrospinal fluid production, blood-CSF barrier, choroid plexus epithelial cells, tight junctions, growth factors, aging, Alzheimer's disease, brain injury, central nervous system infection, multiple sclerosis, autoreactive T cells, leukocyte transmigration, blood-brain barrier
- MeSH terms
- Animals, Blood-Brain Barrier, Brain Diseases, Choroid Plexus, Humans, Tight Junctions
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