Klotho controls the brain-immune system interface in the choroid plexus
Open accessAbstract
mice increased the expression of multiple proinflammatory factors and triggered macrophage infiltration of this structure in young mice, simulating changes in unmanipulated old mice. Wild-type mice infected with the same Cre recombinase-expressing virus did not show such alterations. Experimental depletion of klotho from the choroid plexus enhanced microglial activation in the hippocampus after peripheral injection of mice with lipopolysaccharide. In primary cultures, klotho suppressed thioredoxin-interacting protein-dependent activation of the NLRP3 inflammasome in macrophages by enhancing fibroblast growth factor 23 signaling. We conclude that klotho functions as a gatekeeper at the interface between the brain and immune system in the choroid plexus. Klotho depletion in aging or disease may weaken this barrier and promote immune-mediated neuropathogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There was age-dependent expression of genes encoding secreted proteins, including Klotho, which increased with age.
“There were also age-dependent expression of genes encoding secreted proteins (Figure 3H, S3H, Table S3), including the “anti-aging” gene Klotho (Kuro-o et al., 1997; Zhu et al., 2018), which increased with age (Figure 3H).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Zhu et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804 · see citing works
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S. S., & Flavell, R. A. (1995) · Science · doi:10.1126/science.7535475 · Cited by 1,606 · see citing works
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*
Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K., Baum, M., Schiavi, S., Hu, M.-C., Moe, O., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,356 · see citing works
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works
Origin, fate and dynamics of macrophages at central nervous system interfaces
Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3423 · Cited by 1,209 · see citing works
Microglial priming in neurodegenerative disease
Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Wang, Y., Xu, C.-F., Liu, Y.-J., Mao, Y.-F., Lv, Z., Li, S.-Y., Zhu, X.-Y., & Jiang, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477112 · Cited by 825 · see citing works
A new look at cerebrospinal fluid circulation
Brinker, T., Stopa, E., Morrison, J., & Klinge, P. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-10 · Cited by 819 · see citing works
Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 737 · see citing works
Oslowski, C. M., Hara, T., O’Sullivan-Murphy, B., Kanekura, K., Lu, S., Hara, M., Ishigaki, S., Zhu, L. J., Hayashi, E., Hui, S. T. Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.005 · Cited by 678 · see citing works
Self-citationCanonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.010 · Cited by 674 · see citing works
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
IRF7: activation, regulation, modification and function
Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 590 · see citing works
Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.002 · Cited by 565 · see citing works
Molecular Basis of Klotho: From Gene to Function in Aging
Xu, Y., & Sun, Z. (2015) · Endocrine Reviews · doi:10.1210/er.2013-1079 · Cited by 550 · see citing works
Imura, A., Iwano, A., Tohyama, O., Tsuji, Y., Nozaki, K., Hashimoto, N., Fujimori, T., & Nabeshima, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.090 · Cited by 536 · see citing works
Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499 · see citing works
REGULATION OF MHC CLASS II GENES: Lessons from a Disease
Mach, B., Steimle, V., Martínez-Soria, E., & Reith, W. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.301 · Cited by 487 · see citing works
A Dramatic Increase of C1q Protein in the CNS during Normal Aging
Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H.-H., Huang, E. J., Rowitch, D. H., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-13.2013 · Cited by 423 · see citing works
Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases
Yoshihara, E., Masaki, S., Matsuo, Y., Chen, Z., Tian, H., & Yodoi, J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00514 · Cited by 366 · see citing works
Immunohistochemical Localization of Klotho Protein in Brain, Kidney, and Reproductive Organs of Mice
Li, S.-A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M., & Takei, K. (2004) · Cell Structure and Function · doi:10.1247/csf.29.91 · Cited by 351 · see citing works
Simon, M. J., & Iliff, J. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.014 · Cited by 339 · see citing works
IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair
Kunis, G., Baruch, K., Rosenzweig, N., Kertser, A., Miller, O., Berkutzki, T., & Schwartz, M. (2013) · Brain · doi:10.1093/brain/awt259 · Cited by 321 · see citing works
Nagai, T., Yamada, K., Kim, H., Kim, Y., Noda, Y., Imura, A., Nabeshima, Y., & Nabeshima, T. (2002) · The FASEB Journal · doi:10.1096/fj.02-0448fje · Cited by 312 · see citing works
Baruch, K., Ron‐Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W. O., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211270110 · Cited by 296 · see citing works
The Kidney Is the Principal Organ Mediating Klotho Effects
Lindberg, K., Amin, R., Moe, O. W., Hu, M. C., Erben, R. G., Wernerson, A. Ö., Lanske, B., Olauson, H., & Larsson, T. E. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013111209 · Cited by 296 · see citing works
Self-citationPatterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 281 · see citing works
Klotho suppresses RIG-I-mediated senescence-associated inflammation
Liu, F., Wu, S., Ren, H., & Gu, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2167 · Cited by 268 · see citing works
Maekawa, Y., Ishikawa, K., Yasuda, O., et al. (2009) · Endocrine · doi:10.1007/s12020-009-9181-3 · Cited by 256 · see citing works
Perrone, L., Devi, T. S., Hosoya, K., Terasaki, T., & Singh, L. P. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21852 · Cited by 243 · see citing works
Pothlichet, J., Meunier, I., Davis, B. K., Ting, J. P.-Y., Skamene, E., von Messling, V., & Vidal, S. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003256 · Cited by 225 · see citing works
The immunology of neurodegeneration
Czirr, E., & Wyss‐Coray, T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58656 · Cited by 211 · see citing works
Bone Marrow-derived Macrophage Production
Trouplin, V., Boucherit, N., Gorvel, L., Conti, F., Mottola, G., & Ghigo, É. (2013) · Journal of Visualized Experiments · doi:10.3791/50966 · Cited by 211 · see citing works
Neurocognitive Aging and the Hippocampus across Species
Leal, S. L., & Yassa, M. A. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.10.003 · Cited by 207 · see citing works
The choroid plexus in the rise, fall and repair of the brain
Emerich, D. F., Skinner, S. J. M., Borlongan, C. V., Vasconcellos, A. V., & Thanos, C. G. (2005) · BioEssays · doi:10.1002/bies.20193 · Cited by 202 · see citing works
CNS-specific T cells shape brain function via the choroid plexus
Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 195 · see citing works
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
Semba, R. D., Moghekar, A., Hu, J., Sun, K., Turner, R. L., Ferrucci, L., & O’Brien, R. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.10.058 · Cited by 195 · see citing works
Thioredoxin Interacting Protein: Redox Dependent and Independent Regulatory Mechanisms
Spindel, O. N., WORLD, C., & Berk, B. C. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4137 · Cited by 193 · see citing works
Impact of aging brain circuits on cognition
Samson, R. D., & Barnes, C. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12183 · Cited by 184 · see citing works
Lun, M. P., Johnson, M. B., Broadbelt, K. G., Watanabe, M., Kang, Y., Chau, K. F., Springel, M. W., Malesz, A., Sousa, A. M. M., Pletikos, M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3081-14.2015 · Cited by 178 · see citing works
The Choroid Plexus in Healthy and Diseased Brain
Kaur, C., Rathnasamy, G., & Ling, E.-A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv030 · Cited by 176 · see citing works
Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism
Olauson, H., Lindberg, K., Amin, R., Jia, T., Wernerson, A. M., Andersson, G. N., & Larsson, T. E. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010048 · Cited by 148 · see citing works
Self-citationVitamin D and neurocognitive function
Holick, M. F., & Schlögl, M. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s51785 · Cited by 143 · see citing works
Harris, J. A., Koyama, A., Maeda, S., Ho, K., Devidze, N., Dubal, D. B., Yu, G.-Q., Masliah, E., & Mucke, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045881 · Cited by 135 · see citing works
Self-citationDuce, J. A., Podvin, S., Hollander, W., Kipling, D., Rosene, D. L., & Abraham, C. R. (2007) · Glia · doi:10.1002/glia.20593 · Cited by 131 · see citing works
Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
Shiozaki, M., Yoshimura, K., Shibata, M., Koike, M., Matsuura∥, N., Uchiyama, Y., & Gotow, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.032 · Cited by 131 · see citing works
Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice
Maeda, S., Djukic, B., Taneja, P., Yu, G.-Q., Lo, I., Davis, A., Craft, R., Guo, W., Wang, X., Kim, D., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541438 · Cited by 130 · see citing works
Self-citationIdentification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho
Chen, C.-D., Tung, T. Y., Liang, J. J., Zeldich, E., Zhou, T. B. T., Turk, B. E., & Abraham, C. R. (2014) · Biochemistry · doi:10.1021/bi500409n · Cited by 128 · see citing works
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Deczkowska, A., Baruch, K., & Schwartz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.006 · Cited by 125 · see citing works
Interferons in the central nervous system: A few instruments play many tunes
Owens, T., Khorooshi, R., Włodarczyk, A., & Asgari, N. (2013) · Glia · doi:10.1002/glia.22608 · Cited by 119 · see citing works
Cissé, M., Sanchez, P. E., Kim, D. H., Ho, K., Yu, G.-Q., & Mucke, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1459-11.2011 · Cited by 118 · see citing works
Self-citationZhou, X., Chen, K., Lei, H., & Sun, Z. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013101033 · Cited by 115 · see citing works
Chen, T.-H., Kuro‐o, M., Chen, C., Sue, Y., Chen, Y.-C., Wu, H.-H., & Cheng, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.09.032 · Cited by 101 · see citing works
Bone Marrow-derived Macrophage Production
Trouplin, V., Boucherit, N., Gorvel, L., Conti, F., Mottola, G., & Ghigo, É. (2013) · Journal of Visualized Experiments · doi:10.3791/50966-v · Cited by 101 · see citing works
Dalton, G. D., An, S.-W., Al‐Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby‐Phelps, K., Kohler, J. J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620301114 · Cited by 92 · see citing works
Nuclear localization of Klotho in brain: an anti-aging protein
German, D. C., Khobahy, I., Pastor, J. V., Kuro‐o, M., & Liu, X. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.018 · Cited by 90 · see citing works
Mesquita, S. D., Ferreira, A. C., Gao, F., Coppola, G., Geschwind, D. H., Sousa, J. C., Correia‐Neves, M., Sousa, N., Palha, J. A., & Marques, F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.008 · Cited by 86 · see citing works
Clinton, S. M., Glover, M. E., Maltare, A., Laszczyk, A. M., Mehi, S. J., Simmons, R. K., & King, G. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.06.044 · Cited by 82 · see citing works
Microglial Activation Milieu Controls Regulatory T Cell Responses
Ebner, F., Brandt, C., Thiele, P., Richter, D., Schliesser, U., Siffrin, V., Schueler, J., Stubbe, T., Ellinghaus, A., Meisel, C., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203331 · Cited by 78 · see citing works
A molecular characterization of the choroid plexus and stress-induced gene regulation
Sathyanesan, M., Girgenti, M. J., Banasr, M., Stone, K. L., Bruce, C., Guilchicek, E., Wilczak-Havill, K., Nairn, A. C., Williams, K. R., Sass, S., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.64 · Cited by 74 · see citing works
Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications
Bikle, D. D. (2009) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-009-9033-y · Cited by 73 · see citing works
Massó, A., Sánchez, A., Giménez‐Llort, L., Lizcano, J. M., Cañete, M., García-Lareu, B., Torres–Lista, V., Puig, M., Bosch, A., & Chillón, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143623 · Cited by 73 · see citing works
Stein, L. R., Wozniak, D. F., Dearborn, J. T., Kubota, S., Apte, R. S., Izumi, Y., Zorumski, C. F., & Imai, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4730-13.2014 · Cited by 58 · see citing works
Self-citationVitamin D both facilitates and attenuates the cellular response to lipopolysaccharide
Chen, L., Eapen, M. S., & Zosky, G. R. (2017) · Scientific Reports · doi:10.1038/srep45172 · Cited by 48 · see citing works
BioAge: Toward a multi-determined, mechanistic account of cognitive aging
DeCarlo, C. A., Tuokko, H. A., Williams, D., Dixon, R. A., & MacDonald, S. W. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.003 · Cited by 46 · see citing works
LCTL Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas
Su, J., Ma, Q., Long, W., Tang, H., Wu, C., Luo, M., Wang, X., Xiao, K., Yang, L., Xiao, Q., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01083 · Cited by 27 · see citing works
The in vivo effects of a fraction from Dioscorea spongiosa on glucocorticoid-induced osteoporosis
Han, N., Xu, J., Feng, X., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.033 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of cognitive dysfunction in CKD
Viggiano, D., Wagner, C. A., Martino, G., Nedergaard, M., Zoccali, C., Unwin, R., & Capasso, G. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0266-9 · Cited by 392 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
Pluvinage, J. V., & Wyss-Coray, T. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0255-9 · Cited by 191 · see citing works
Blood-to-brain communication in aging and rejuvenation
Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156 · see citing works
Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
Typiak, M., & Piwkowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020956 · Cited by 107 · see citing works
Johnson, E. C. B., Ho, K., Yu, G.-Q., Das, M., Sanchez, P. E., Djukic, B., Lopez, I., Yu, X., Gill, M., Zhang, W., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00393-5 · Cited by 73 · see citing works
Self-citationLuthra, N. S., Clow, A., & Corcos, D. M. (2022) · Brain Sciences · doi:10.3390/brainsci12121695 · Cited by 20 · see citing works
- Authors
- Zhu, L., Stein, L. R., Kim, D., Ho, K., Yu, G.-Q., Zhan, L., Larsson, T. E., & Mucke, L.
- Affiliations
- Gladstone Institutes (US)
- Karolinska Institutet (SE)
- Corresponding author
- Mucke, Lennart
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-11-09
- Volume
- 115
- Issue
- 48
- Pages
- E11388-E11396
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6275534
- OpenAlex
- W2900439582
- Cited by
- 148
- References
- 78
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 21 · 2023: 23 · 2022: 22 · 2021: 19 · 2020: 23 · 2019: 8
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- US National Institutes of Health (NS088532)
- Ray and Dagmar Dolby Family Fund (N/A)
- Ruth L. Kirschstein National Research Service Award (NS093766)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- Klotho, choroid plexus, aging, microglial activation, macrophage infiltration, NLRP3 inflammasome, TXNIP, inflammatory cytokines, lipopolysaccharide, hippocampus, neuroinflammation
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Klotho Proteins, Aging, Animals, Brain, Choroid Plexus, Female, Glucuronidase, Hippocampus, Humans, Macrophages, Male, Mice, Inbred C57BL, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
